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Juquitiba na modernidade: uma análise da condição socioespacial
(Universidade Federal de São Carlos, 2018-08-21) Marcelino, Denise de Camargo; Mariano, Neusa de Fátima; https://lattes.cnpq.br/5003743301847104; https://lattes.cnpq.br/7381414457704564
The objective of this study was to identify the process of expansion of the urban way of life that induces socio-spatial segregation, and how an economic and social formation of the place is resistant and present: a temporality parallel to that of global time, which is still part of modernity. The analysis used the concept of place better describe this temporality, starting from the scale of the neighborhood inserted in the municipality. The neighborhood, containing a specific socio-spatial formation, which, not totally achieved by the urbanization of life, is a testimony of a differential temporality that is defended modernity. The importance of place becomes essential to move transformations and give individuals the strength to transform their world, allowing the coexistence of contrasting times in space.
Estudo de vias alternativas aos sistemas LiaFSR e YycFGHIJ que levam à diminuição da sensibilidade à daptomicina em Enterococcus faecium
(Universidade Federal de São Carlos, 2018-08-21) Mello, Suelen Scarpa de; Camargo, Ilana Lopes Baratella da Cunha; https://lattes.cnpq.br/4104096171600845; https://lattes.cnpq.br/8568026403283913
Enterococcus is one of the most important multi-drug resistant nosocomial pathogens. Infections caused by vancomycin resistant Enterococci (VRE) are becoming increasingly difficult to treat, often with prolonged hospital outbreaks that are real challenges. Daptomycin (DAP) is a drug of last resort for treating infections caused by VRE; mainly E. faecium belonged to clonal complex 17, called "high risk" clone. In this study, samples of E. faecium from the Hospital de Base de São Jose do Rio Preto were analyzed by molecular typing and the susceptibility profile to several antimicrobials was determined. A high-risk vancomycin-resistant clone with reduced susceptibility to daptomycin has been identified spreading in the hospital. The mechanism of DAP resistance is not fully elucidated. For the purpose of studying the mechanism of resistance to DAP in the clinical isolates of this hospital and to identify new pathways to resistance, DAP hyper-susceptible E. faecium HBSJRP18 clinical isolate was used to perform in vitro selections until resistant mutants were obtained. Subsequently, genes with mutation in these selected isolates, as well as those already described in the literature, were analyzed in the clinical samples. Genomes of these mutants were sequenced and compared to the DAP hyper-susceptible E. faecium HBSJRP18 to detect the presence of single nucleotide polymorphism (SNP) in genes that may be related to resistance to DAP. The mutated/intact genes were overexpressed in the hyper-susceptible/resistant strain, thus DAP MIC was determined to investigate their roles in resistance to that antibiotic. The genes that showed mutations in the three BHI selections were lafB-like, a glycosyltransferase possibly involved in the LTA biosynthesis, and dhaK, a dihydroxyacetone kinase possibly involved in the metabolism of glycerol. Cloning and overexpression of the genes of interest were performed, which enabled the evidence of the role of lafB-like in hyper-susceptibility to DAP. dhaK still remains unclear if it is actually involved in resistance. Mutations in these genes were also found in all clinical samples, as well as the liaFSR genes already described in the literature. The findings of this study have a particular importance considering that vancomycin-resistant E. faecium infections have grown frighteningly in the present day. The lafB-like gene may be a potential therapeutic target and should be better studied for this.
Diagnóstico da Rede Sociotécnica de Inovação em uma Instituição Federal de Ensino Superior
(Universidade Federal de São Carlos, 2018-08-21) Silva, Daniela Salgado Gonçalves da; Gracioso, Luciana de Souza; https://lattes.cnpq.br/4898201916360294; https://lattes.cnpq.br/2401064231048780
Innovative activity is considered a social and collective process, in which its learning takes place through interactions. The more complex the learning, the greater the need for interaction and complementarity. Therefore, there is an open interaction environment that depends on the communities and networks of innovation that should create value and bring collective benefits. In this sense, the present research aims to diagnose the articulation existing in the strategic sectors formed by a sociotechnical network linked to the management of innovation in a São Paulos’s state Federal University and, to identify with the sector representatives, which strategies could be implemented to increase the effectiveness of the processes managed by this network. It is a qualitative-quantitative research whose strategy is the case study by means of the inductive method, where an empirical investigation was carried out that contemplated evaluating a contemporary phenomenon within its real context. As a time cut for data collection, we have the period between the second half of 2016 and the first half of 2018, with a view to identifying which are the institutional networks, how they flow from the perception of the sector representatives, and what results can we from the perceptions identified in the interviewees' statements. As for the use of results, this is an applied research whose practical emphasis is on problem solving. As for the ends, it is a descriptive research. As for the nature of the method, it is a qualitative-quantitative research. The case unit is a governmental organization, part of the apparatus of the State, from the public management, non-profitable character with type of academic organization: University. The current reality of the structure linked to the management of innovation of this institution is seen in this research as the central problem. This work aimed to describe, analyze and identify the degree of sector interaction and level of articulation of this sociotechnical network of research and innovation management based on the following question: "Considering the social responsibility of a federal university in the interior of the state of São Paulo, to what extent does the political and administrative articulation of the sociotechnical network for innovation management occur, since there is a potential possibility of sectoral integration that has a positive impact on institutional management?" This research is justified by the importance of the Scientific, Technological and Innovation Institutions (STII), including public institutions of higher education, in mapping processes with the establishment of an articulated network in which to better organize their scientific capital, financial and human resources expended in the aggregate of a considerable burden of bureaucratic, academic, research and financial activities. The assumptions of the study consider that the articulation between the actors of this network is deficient and that, due to the constant movement of the unstable political scene, as well as of the updates in the legislation related to science, technology and innovation, the university starts to implement organizational arrangements for to meet the requirements of the federal government and to meet the requirement of social responsibility, but not necessarily promoting integration in its entirety among the strategic sectors. At the end of this research, we were able to identify the perception of the representatives of the analyzed organizational units and to point out strategic elements that which aim to contribute to the public management of this institution. The result contributed to generating a suggestion of articulation and strategic sector interaction in this organization, in order to foster the management of innovation, based on the current reality, a new administrative and political team that assumed its functions for the 2017- 2020.
Um olhar crítico-libertador sobre o movimento de construção curricular da rede municipal de Sorocaba entre 1999 e 2007
(Universidade Federal de São Carlos, 2018-08-21) Nunes, Fabiana Boschetti; Torres, Juliana Rezende; https://lattes.cnpq.br/3083345943491817; https://lattes.cnpq.br/2260101923416580
The present research deals with the movement of curricular construction of the municipal network of Sorocaba between the years 1999 and 2007, with the objective of investigating the approximations and distances of this one with Paulo Freire's conception of critical-liberating curriculum. It presents a qualitative approach and makes use of bibliographical and documentary research to find the results. The main theoretical bases were: Paulo Freire, Moisey Mikhaylovich Pistrak, Luiz Carlos de Freitas, Antonio Flavio Barbosa Moreira, Thomaz Tadeu da Silva, Ivor F. Goodson, Antonio Fernando Gouvêa da Silva, Ana Maria Saul, Alice Cassimiro Lopes, Demétrio Delizoicov, among others. In the preliminary analyzes, we observed an apparent approximation of the Sorocaba curriculum with the Freirean curriculum perspective, when we find the texts of Paulo Freire, the readings of the innovative experiences coming from the municipalities and the technical staff of the Paulo Freire Institute (IPF, 1998 - like the Citizen School of Porto Alegre). Among the results of the curricular movement of this municipality in constructing a curriculum concerned with the local reality and its articulations with the school knowledge, initially, we observed that this curriculum sought to break the logic of the linear content, of the sequences of contents designated by didactic books, understanding that the specific concepts of the areas of knowledge are not an end in itself, given that such a concept, in a critical-liberating perspective, should be in the service of a social practice. We explain that this curricular proposal, once analyzed based on the curricular theories, went through the three (traditional, critical and post-critical) and also identified the presence of the freirean categories addressed: dialogue, problematization of reality and praxis implicitly, without deepening or distant from conception in Freire, because at that time, the organization of teaching through thematic complexes was mistakenly seen in relation to the generative themes proposed by Paulo Freire.
Enigma do tempo: o problema da objetividade na contraposição entre Heidegger e Cassirer
(Universidade Federal de São Carlos, 2018-08-21) Mergulhão, Adriano Ricardo; Santos, Paulo Roberto Licht dos; https://lattes.cnpq.br/1681044854219924; https://lattes.cnpq.br/5484918883344452
This thesis analyses the objectivy problem in both Heidegger and Cassirer works, using the time concept as connecting thread for the comprehension of the existente counterpoint between their theories. This sistematic aprouch makes a reconcilemente of their main thesis possible, because both of them proposes a rereading of the kantian transcendental philosophy, using diferente aproaching methods for a common problem. Thus, the objectivity problem will be discussed, starting from the symbolic-epistemological perspective of Cassirer and the phenomenological-hermeneutic position of Heidegger, according to the positive contrast established between them. We propose that, even having some divergences, both authors enphasize the time concept centrality, implied to the imagination function, exposede in the chapter of the kantian transcendental schematism, as a ground for compreension of the objectivy problem. Therefore, we maintain that there is an interdependence from the antagonism of their positions, because, both center their arguments on the relation between the productive imagination and the objectivity, thematic that propitiates a common ground for the opening of a proficient dialogue. Therefor, the objectivity problem, goal of continuous inquiry in the Heidegger´s proposals and Cassirer´s motions, it will be only properly clarified with the analysis of implications that the time concept acquires in each philosopher’s doctrines, allowing in this way the reciprocal discernment of this theoretical purposes, that overcomes an one-side and preconceived theoretical dichotomy.