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Efeitos da meta-clorofenilpiperazina (mCPP) avaliados no teste de catalepsia em ratos machos e fêmeas
(Universidade Federal de São Carlos, 2022-09) Calerá, Aline Daiany; Reimer, Adriano Edgar; Oliveira, Amanda Ribeiro de; https://lattes.cnpq.br/4993675879410961
Meta-chlorophenylpiperazine (mCPP) is a synthetic non-selective agonist of serotoninergic receptors, which has been used in the study of several psychopathologies such as Obsessive-Compulsive Disorder (OCD). In these studies, mCPP has demonstrated motor effects of increasing or decreasing locomotor activity in animals in a dose-dependent manner and probably due to an interaction between the 5-HT2C serotonergic receptors and their regulation of dopaminergic neurotransmission. Some studies carried out with females have shown a possible influence of the estrous cycle on the effects of mCPP. However, more studies are necessary to further understand such differences. The present study aimed to evaluate whether mCPP induces catalepsy in Wistar rats, and to verify if there are differences in the results presented between male and female rats in different phases of the estrous cycle. For this, Wistar rats were used, 72 males and 77 females, weighing approximately 250 g. The animals received saline (control) or mCPP in the doses of 0.1 mg/kg, 1.0 mg/kg, 3.0 mg/kg, and 10 mg/kg, and the positive control group received haloperidol (dopamine D2-like receptor antagonist) at a dose of 1.0 mg/kg. After administration, every 10 min, a catalepsy test was performed, totaling 6 tests. Haloperidol was able to induce catalepsy in both males and females. The cataleptic effect of haloperidol was dependent on the phase of the estrous cycle in females, being observed in metestrus/diestrus females, but not in those tested in proestrus/estrus. mCPP, on the other hand, did not cause catalepsy in males or females, regardless of the phase of the estrous cycle. The results obtained with mCPP suggest that the motor alterations observed in previous studies are different from those that characterize cataleptic states. Such findings are important in the context of using mCPP for the study of OCD and indicate that the assessment of mCPP-induced compulsive-like behaviors would not be impaired by drug-induced cataleptic effects.
A imagem como manifesto: fragmentos de uma gráfica ativista brasileira
(Universidade Federal de São Carlos, 2022-09-01) Faca, Camila Carvalho; Martinez, Vinício Carrilho; https://lattes.cnpq.br/7916014556126573; https://lattes.cnpq.br/5873839155165158
In September 2018, millions of Brazilians took to the streets with their posters for the #elenão movement. In this period, there was an intense mobilization by graphic artists, illustrators, scriptwriters, communicators from all over Brazil, who worked creatively and collectively, giving rise to a movement of graphic agitation that started in cyberspace and moved to the streets. This research presents discussions about the production and reproduction of visual protest artifacts, tied to the use of digital networks, specifically addressing the relationships of this visual material with Brazilian society in the context of the 2018 #elenão protests.
Terapia ocupacional, registro em prontuário e as percepções da equipe hospitalar
(Universidade Federal de São Carlos, 2022-09) Campos, Mirella Andreza de; Bombarda, Tatiana Barbieri; https://lattes.cnpq.br/8070700589653226; https://lattes.cnpq.br/2901031410565524
Among the procedures carried out by the occupational therapist in the hospital is the medical record. The record in the medical record aims to facilitate communication among professionals, support decision making, promote the quality of comprehensive care, guide the establishment of the patient's needs and potential as a single subject and integrate the various knowledge. Aiming at understanding the use of medical records by the hospital team and the access to the records produced by occupational therapists, this exploratory study, with a qualitative approach, interviewed professionals from the multidisciplinary team working in a medical clinic ward, using the snowball method for participant selection. The interviews were conducted through the Google Meet platform, and the information was transcribed and analyzed by thematic content. The information about the purpose of this use was organized into three categories: documentation of care practice, consultation of data about the patient and about his care plan and communication/exchange of information between team members. It was evaluated that the records produced by occupational therapists help other professionals in care planning, and the consultation of these records is based on two categories: verification of interventional information for alignment of the care plan, understanding of the impacts of illness and adaptive responses. The content of such categories show the search for information beyond functional and rehabilitation aspects, as well as the impacts experienced by the patient with the process of illness and hospitalization, a factor that highlights an expanded and contemporary look about the scope of occupational therapy. It was concluded that the structuring of information was pointed out as a potentiality of occupational therapeutic records, however, there was perceptive variability about the level of clarity of information, a factor associated with professional training and the substantiation of information from the occupational perspective.
Cross-cultural adaptation and psychometric evaluation of the Brazilian Portuguese version of the Vulvovaginal Symptoms Questionnaire
(Universidade Federal de São Carlos, 2022-09) Alem, Michele Elisabete Rubio; Chaves, Thais Cristina; Figueiredo, Vilena Barros de; Beleza, Ana Carolina Sartorato; Ferreira, Cristine Homsi Jorge; Silva, Jordana Barbosa da; Driusso, Patricia; https://lattes.cnpq.br/8898319491890063
Objective The aims of this study were to perform a cross-cultural adaptation of the Vulvovaginal Symptoms Questionnaire (VSQ) into Brazilian Portuguese (VSQ-Br) and evaluate its measurement properties (structural validity, construct validity, internal consistency, and reliability). Methods Cross-cultural adaptation was conducted through the translation, synthesis, and back-translation of the VSQ-Br. Subsequently, 314 women completed the Pelvic Floor Impact Questionnaire, Pelvic Floor Disorders Inventory, Medical Outcomes Study 36-Item Short-Form Health Survey, and VSQ-Br. Seven to 10 days later, participants completed the VSQ-Br for the second time. Data were submitted for confirmatory factor analysis. Cronbach α was used to verify internal consistency, and construct validity was assessed using Pearson correlation coefficient (r). Reliability was calculated using the intraclass correlation coefficient. Results Confirmatory factor analysis showed that the questions were grouped into four domains (symptoms, emotions, life impact, and sexual impact). The model showed good fit (>0.95). The Cronbach α in this study was 0.85, reflecting adequate internal consistency. Adequate reliability was confirmed, with an intraclass correlation coefficient total score of 0.80. The VSQ-Br had a weak correlation with the pelvic domain of the Pelvic Floor Disorders Inventory, the pelvic organ prolapse domain of the Pelvic Floor Impact Questionnaire, and pain, vitality, and the social aspect domains of the Medical Outcomes Study 36-Item Short-Form Health Survey. Conclusions The VSQ-Br was validated and had acceptable measurement properties for assessing vulvovaginal symptoms in Brazilian women.
Autoestima e autoimagem de mulheres idosas. Sob o olhar de produtoras de conteúdos digitais em uma rede social
(Universidade Federal de São Carlos, 2022-09-01) Custódio, Júlia; Pedro, Wilson José Alves; https://lattes.cnpq.br/8135701448186851; https://lattes.cnpq.br/5265675364894628
Introduction: With the increase in life expectancy, the age distribution of the world population has changed to older ages. Along with these changes, the epidemiological transition and the increase in the feminization of old age were also born. Recent studies have shown that low self-esteem and the difficulty of accepting self-image among women aged 60 years or older, together with the constant search to meet stereotypes of society, have become common and capable of generating several biopsychosocial losses, including depression. Therefore, it is essential that professionals from different areas go beyond the limits of the clinical model of care, aiming to meet the needs of each person in their entirety, focusing on innovative actions. General objective: to understand and analyze behaviors, manifestations and positions of older women, content producers, on relational aspects of self-esteem and self-image in profiles of a social network (Instagram). Method: The current project is a pluviometric study, of a qualitative, descriptive, and documentary nature of netnographic, exploratory and transversal character, with an interdisciplinary theoretical focus in the field of Sciences, Technologies and Society and Gerontology, being determined by analysis, for a short period of time. Related to qualitative aspects, their central objective is the observation of content production and interactions, provided by networks, between older women and their followers in social networks (FONSECA, 2002).
Análise da flambagem de paredes de alvenaria estrutural
(Universidade Federal de São Carlos, 2022-09-01) Padilha, Tiago Montanha; Nascimento Neto, Joel Araújo do; https://lattes.cnpq.br/2747505817148030; Parsekian, Guilherme Aris; https://lattes.cnpq.br/7798651726059215; https://lattes.cnpq.br/6854921502566663
This research presents analyzes of slender reinforced masonry walls built with concrete units. The analysis was performed with finite element modeling. The Abaqus computational package was used to develop the models. Slender walls are found both in buildings without a ceiling slab and in buildings with double height ceilings. The failure mode of these walls is lateral instability, also called buckling effect. Few standards allow the design of walls with high slenderness. Most standards and codes establish a certain maximum slenderness ratio value for which their methods are valid. These values have been questioned in recent scientific publications that indicate large capacity reserves in walls with slenderness close to or even greater than the maximum slenderness established in standards. The Brazilian standard establishes the slenderness ratio equal to 30 is the maximum for which the simplified method is valid for reinforced walls. The standard published in 2020, presents a more accurate method, which includes the effects of second order, to enable the design of walls with slenderness greater than 30. In addition to the formulations, the standard presents mandatory specifications. Due to the recent inclusion of this method in the Brazilian standard and the recent scientific publications, this research aims to answer: what is the accuracy of the method established in the Brazilian standard for the design of tall slender walls in structural masonry? In the parameter variation analysis, different reinforcement rates and different vertical bar positions were investigated, the compressive strength of the concrete unit equal to 8 MPa and 16 MPa and the slenderness ratio equal to 30, 40 and 50. The results indicate good agreement with the behavior of slender walls, but with imprecision regarding the stiffness of reinforced sections and with high loadings close to the critical load values. For all the models analyzed, the method resulted in significant reserves of load capacity due to the effects of geometric nonlinearity. Every wall failed due to geometric instability, indicating that the slenderness parameter equal to 30 to differentiate the buckling failure mode is adequate.
Sequência didática em perspectiva dialógica para ensino de ecologia
(Universidade Federal de São Carlos, 2022-09-01) Bitarães, Vitória da Silva; Calzolari Neto, Anselmo João; https://lattes.cnpq.br/4906309581958797; https://lattes.cnpq.br/6983717663810971
In biology teaching, and specifically in ecology teaching, the contents are fragmented. In addition, it uses teaching and learning approaches, developed in and for industrial societies, as is the case of significant learning, but in contemporary societies are information and knowledge, enabling communicative and dialogic interactions, but also increasing risks. Thus, it is necessary the use of teaching and learning perspectives that respond to these societies and at the same time enable the transformation of unequal conditions. The present work aimed to propose and analyze the proposal of a didactic sequence in the teaching of ecology from the Dialogical Learning and methodologically structured in the Three Pedagogical Moments. Both references are due to the dialogic action present in their own foundations. Moreover, it had as thematic approach, the disappearance of bees, enabling studies about the Ecological Balance. Finally, it is concluded that it is possible to study the contents in the school from the contemporary, but it is necessary the application of this didactic sequence to analyze the real effects on the learning of the students.
Estudo do efeito do silenciamento do gene ITGB3 em células tumorais de mama
(Universidade Federal de São Carlos, 2022-09-01) Nunes, Ana Carolina Caetano; Altei, Wanessa Fernanda; https://lattes.cnpq.br/3727790337302830; Araújo, Heloísa Sobreiro Selistre de; https://lattes.cnpq.br/4065824911933203; https://lattes.cnpq.br/3613731328474011
Breast cancer is the major disease that affects women, especially the triple negative phenotype, which has the worst prognosis and metastatic potential. Included, metastasis is still the main cause of death in cancer patients and its development involves several stages and characters that play important roles, such as the tumor microenvironment and the extracellular matrix (ECM). Integrins also contribute to metastasis, especially the αvβ3 integrin whose overexpression is associated with every step in tumor progression. Among the molecules that interact with integrins, there are disintegrins, which are small proteins derived from snake venom metalloproteases. DisBa-01 (Disintegrin of Bothrops alternatus-01) is a recombinant protein derived from the Bothrops alternatus venom (urutu-cruzeiro) snake, which has a high affinity for this integrin. Thus, this work aimed to study the effects of silencing the β3 subunit in tumor cells of the triple negative breast adenocarcinoma cell line (MDA-MB-231). Therefore, the methods adopted involved the cell culture of human kidney embryonic (293FT) and wild and modified triple negative breast adenocarcinoma (MDA-MB-231) cell lines; production of ITGB3 shRNA lentivirus as well as target cell transduction and the validation of silencing by RTqPCR and immunofluorescence. We also verified possible alterations in the expression of other integrin subunits; functional assays (inhibition of adhesion, migration by wound healing and transwell), and the identification of metalloproteases (MMP) (MMP-2 and MMP-9). We compared the cellular responses of the silenced lineage with the action of DisBa-01 (1000 nM). The silencing took to a 69% reduction in ITGB3 mRNA and a 49% reduction in FN rich microenvironment, with an increase in β1, α1 and α5 subunits; increased adherence to FN (58%) and COL I (83%) proteins; decreased transwell migration (69% inhibition) and MMP-9, responses different from those obtained with DisBa-01. The generation of this new cell line opens perspectives for its use as a tool in future studies of the basic biology of breast cancer.
Estudo de caso: proposta de implantação de conceitos da indústria 4.0 para a coleta e controle de indicadores operacionais em uma estação de tratamento de água e efluentes
(Universidade Federal de São Carlos, 2022-09-01) Massei, Alexandre Nocera; Silva, Edson Luiz; https://lattes.cnpq.br/9720274214573371
Currently, in Brazilian industries, it is common to find routine procedures and data control performed on paper, or in an offline mode. With the context of COVID-19, the number of employees working face-to-face in factories has decreased, both because of the pandemic and the hybrid working model. With this, access to information in these routines, such as the collection of operational indicators, and the execution of these routines has been hampered. To solve this problem many companies are adopting strategies based on Industry 4.0 concepts and applications with the aim of transforming their procedures digital and decentralized, with as little human effort as possible. Industry 4.0 can be explained as a revolution in factory connectivity, associating people, machines, information, and knowledge. A more connected factory is able to make decisions faster, and in a more assertive way, since it will be based on more reliable data, processed in real time, with only computational effort. With greater efficiency and quality in operational work, strategic work can come more into focus. In this paper a case study was explored, on how Ingredion's water and wastewater treatment plant in Mogi Guaçu - SP was able to use common Industry 4.0 concepts to transform a routine procedure, the collection of operational indicators, which was done in a totally manual and paper-based way, to an automatic, digital and decentralized process. This approach brings new insights for the expansion of Industry 4.0 in Brazil, both with the human view of the changes that took place, and the technical view of how these changes impact the process as a whole. In this way, the objective of the work was to present inputs and results of a real example of the application of Industry 4.0 to solve a common problem, the collection of daily operational indicators of production, as well as the solution for the digitalization of these data and future display of them in a decentralized and agile way, built from the author's internship. In the work, which followed the methodology of presenting the main concepts used for subsequent practical application with the case study, it can be evidenced the improvements presented after the implementation of the project, such as savings in time for data collection and compilation, bringing an improvement of at least 2 hours a week in these aspects, and opening space for various analyses that were not done.
Construção de uma revista de divulgação científica para o ensino fundamental ii como estratégia de sensibilização ambiental para a conservação de anfíbios
(Universidade Federal de São Carlos, 2022-09-01) Oliveira, Raissa Marin de; Fernandes, Hylio Laganá; https://lattes.cnpq.br/1315602045624096
The Amphibia class is represented by the orders Gymnophiona, Caudata and Anura. In 2021, in Brazil, 1,188 species of amphibians were recognized. The group is quite diverse and presents several morphological and ecological contrasts. However, they represent the most endangered class among vertebrate animals, mainly due to human activities. The dissemination of popular beliefs and some tales and songs that promote the stigmatization of amphibians, generates damage to their conservation, as society does not realize the relevance of these animals to the environment. This work focuses on the process of creating a science magazine for elementary school students II, as well as the production of a board game for environmental awareness. The goalspecific of these materials is to present scientific information about general aspects of amphibians, ecological importance and the factors that are causing the decline of the class. The reading of science communication texts provides access to scientific knowledge in a simple way, the perception of science in everyday life and scientific literacy, as well as stimulates curiosity. Games, being a playful activity, are closely related to awareness processes, as they can also collaborate in the construction of knowledge. Through games, students develop different skills, such as: imagination, quick thinking, respect for rules and socialization. Thus, when associated with education, games help in social, affective, moral and cognitive development, generating several gains in the teaching and learning process.
Charges na pandemia: subjetividade e condição humana
(Universidade Federal de São Carlos, 2022-09-01) Liberatti, Diana Siqueira; Gatti, Márcio Antonio; https://lattes.cnpq.br/0369563657842763; https://lattes.cnpq.br/5197707223423080
This work has a main theme the subjectivity and the human condition in contemporary political cartoons during the Covid-19 pandemic, aiming at the analysis of speeches and texts that circulated in the first quarter of the social isolation imposed by the quarantine period, between the months of March and May 2020 initially. From an interdisciplinary perspective that encompasses the precepts of French Discourse Analysis and issues relevant to the disciplines of the humanities, with theorical contributions by Maingueneau (2007 and 2018), Burke (2004 and 2017), Possenti (2004), Han (2017), among others, the analyzed texts were selected in social media (Facebook and Instagram), being listed, mainly, the productions of the cartoonist Laerte and the movement that became know as “continuous charge”, and took place from June, 2020. Circumscribed in a certain historical-ideological materiality, the political cartoon text can produce a series of meanings from its generally intense circulation and the relationship it establishes with discourse within the interdiscourse. Thus, it was possible for us to understand the subjectivities from the meanings conveyed in the speeches, and to verify how the socio-historical materiality affects these language productions. In addition, we discuss the discursive genre continued political cartoon, showing how its relations as a discourse and social movement materialize.
Ler e falar a língua indígena Balatiponé dentro de seu contexto cultural
(Universidade Federal de São Carlos, 2022-09-01) Quezo, Luciano Ariabo; Martins, Maria Sílvia Cintra; https://lattes.cnpq.br/9241992645160356; https://orcid.org/0000-0003-3911-418X; Balatiponé; https://lattes.cnpq.br/8417951263528188; https://orcid.org/0009-0009-2548-0382
The core of this Master’s Thesis is to present a Didactic Sequence of reading and practice of the Balatiponé indigenous language for students from the 6th (sixth) year of Elementary School at the indigenous school of the Balatiponé territory to broaden the knowledge of this linguistic system. It aims to generate social repercussions with the indigenous community in which the research was conducted, thus taking advantage of the interest of young people and adults in expanding their knowledge regarding this language. Another position of considerable importance sought here is that this work can promote a profound meaning to the University from a political perspective, understanding that this scope has been demanded by research presented by indigenous people from their presence as students. Therefore, the production of this material reinforces this symbolic mark in contemporary Brazil, which is the advent of indigenous epistemology at the University presented by indigenous people more frequently in the last two decades. The first methodological steps of this research involved carrying out a bibliographical survey with indigenous teachers who have already released language materials, as well as linguistic records of non-indigenous researchers, in addition to making use of the author researcher's knowledge of their mother language. The second step was to dialogue with teachers who work in the languages area at the Julá Paré School in the Balatiponé territory to obtain better information about what is being built at the school in terms of Balatiponé language. The third step, based on the previous steps and with the exploration of the author’s models who carried out similar projects, builds a Didactic Sequence to read and speak the Balatiponé indigenous language. To contribute to strengthening the training of professionals in Indigenous Intercultural Basic Education, as well as for school education in the indigenous villages, encouraging the resumption of the Balatiponé indigenous culture and language.