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Atividades educacionais desenvolvidas no Brasil para profissionais e graduandos em saúde com foco em segurança do paciente: Scoping review
(Universidade Federal de São Carlos, 2023-08-02) Vieira, Vanisia Sulpino; Feliciano, Adriana Barbieri; https://lattes.cnpq.br/9398810638733882; https://orcid.org/0000-0003-2524-9876; Rocha, Sheyla Ribeiro; https://lattes.cnpq.br/7693707560066684; https://orcid.org/0000-0003-2430-8176; https://lattes.cnpq.br/7693707560066684; https://orcid.org/0000-0003-2430-8176
Theoretical debates on patient quality and safety have been widely discussed, but fewer studies have focused on educational activities for healthcare professionals in this context. The training of these professionals is essential in promoting safe care and preventing adverse events. Investing in patient safety education is a strategy to achieve harm-free healthcare. However, healthcare services face challenges in implementing the National Patient Safety Program and ensuring quality care. Therefore, it is important to identify the scientific literature that evidences the state-of-the-art educational activities for patient safety. Objective: The objective of this study is to map and present the scientific literature on educational activities focused on patient safety, developed with healthcare professionals and undergraduate students in Brazil. The basic themes of the National Patient Safety Program will be considered. This will be done through a scope review. Methods: The theoretical frameworks were selected through a literature review, following the scoping review method and the protocol of the Joanna Briggs Institute. The consulted databases included the National Library of Medicine (PubMed), the Latin American and Caribbean Center on Health Sciences Information (BIREME), the Scientific Electronic Library Online (Scielo), Web of Science, the Cumulative Index to Nursing and Allied Health Literature (Cinahl), the Education Resources Information Center (ERIC), and the multidisciplinary database (Scopus). National and international publications in English, available online and published from 2013 onwards were selected. A total of 1422 records were found in the searches, and a selection of 12 research articles including theses, dissertations, and scientific papers, were presented in the flowchart of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (Prisma) recommendations. The selected studies were organized in tables, presenting information such as number, author, year of publication, Brazilian region, study type, study objective, participants, theoretical framework, educational intervention goals, National Patient Safety Program theme addressed, course content, educational strategy, instructional resource, intervention duration, and outcome level according to the Kirkpatrick method, as well as the institution promoting the educational activity. Results: The Brazilian regions that published the most studies on educational activities for patient safety were the South and Southeast. The studies presented various methods, with experience reports being the most frequent. Regarding methodology, qualitative approach was the most utilized. The nursing team (nurses, technicians, and nursing assistants) was the predominant population in the studies. The main findings regarding the most utilized educational strategies were realistic simulation and problematization. The most addressed themes of the National Patient Safety Program were healthcare-associated infection and safety in prescription, medication use, and administration. Conclusions: This review allowed the identification of critical factors for the development and improvement of educational interventions related to patient safety, adherence to the main protocols of the National Patient Safety Program, as well as gaps in educational interventions regarding effective communication and the importance of evaluating trainings, as well as measuring their impact on healthcare.
On the classification of two dimensional flows
(Universidade Federal de São Carlos, 2023-08-02) Thomaz, Rodrigo; Braun, Francisco; https://lattes.cnpq.br/5890727692959507; https://orcid.org/0000-0003-3594-9809; https://lattes.cnpq.br/3366281590933587; https://orcid.org/0000-0002-3924-9810
Lawrence Markus, a well-known mathematician, published, in 1954, a strong result about classification of planar vector fields. Afterwards, Dean Arnold Neumann generalized such work for continuous flows, and the result became known as the Markus–Neumann Theorem. Recently, in 2018, José Ginés Espín Buendía and Víctor Jiménez López wrote a paper exposing gaps in the two aforementioned articles. We present here a discussion on these classical results of classification of planar vector fields and continuous flows, going through the three cited works and elaborating on definitions, examples and proofs.
Cobalt(III)-py2en systems as potential carriers of β-ketoester-based ligands
(Universidade Federal de São Carlos, 2023-08-02) Mello, Marcos Vinícius Palmeira de; Caballero, Ana Belen; Herrera-Ramírez, Piedad; Costa, Analu Rocha; Santana, Savyo Souza; Guedes, Guilherme Pereira; Caubet, Amparo; Batista, Alzir Azevedo; Gamez, Patrick; Lanznaster, Mauricio; https://lattes.cnpq.br/8894654634441028; https://orcid.org/0000-0003-2550-5315
Two cobalt(III) complexes containing different β-ketoesters, namely [CoIII(L1)(py2en)](ClO4)2⋅H2O (1) and [CoIII(L2)(py2en)](ClO4)2 (2) (py2en = N,N′-bis(pyridin-2-ylmethyl)ethylenediamine; L1¡ = methylacetoacetate; L2¡ = ethyl 4-chloroacetoacetate) have been prepared and investigated as prototypes of bioreductive prodrugs. The presence of β-ketoester and py2en ligands in 1 and 2, as well as the perchlorate counterions, was supported by IR spectroscopy and CHN elemental analysis. The composition molecular structure of both complexes was confirmed by NMR spectroscopy and ESI mass spectrometry. Structural information was also obtained for 2 via Xray diffraction analysis. The redox properties indicate that 1 and 2 are suitable for reduction under biological conditions. Investigation of DNA-interacting suggest that 1 and 2 bind DNA via electrostatic forces. Both complexes may be employed as possible platforms for the delivery of biologically active compounds, since their reaction with ascorbic acid in PBS at pH 6.2 and 7.4 at 37◦C results in the release of the β-ketoester ligands upon Co(III)/Co(II) reduction.