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Estudo de azaçúcares como inibidores de Glge, uma maltosiltransferase de Mycobacterium tuberculosis, por meio de docking molecular e da avaliação de interações moleculares
(Universidade Federal de São Carlos, 2023-11-13) Pedroso, Sofia Dallasta; Zukerman-Schpector, Julio; https://lattes.cnpq.br/4252331837170383; https://orcid.org/0000-0003-2191-4074; https://lattes.cnpq.br/8054606648208210; https://orcid.org/0000-0003-4490-5373
Tuberculosis is still a worrying disease around the world, especially in low- and middle-income countries. Current treatment for tuberculosis involves a combination of antibiotics, however, it is often ineffective due to drug resistance and the difficulty of completely eliminating the disease-causing bacteria, namely Mycobacterium tuberculosis. In this context, the use of molecular docking is a promising tool in the development of new drugs for the treatment of tuberculosis. Molecular docking consists of the computational analysis of the fitting of a drug candidate molecule with bacterial proteins, thus allowing the identification of promising compounds and optimizing their effectiveness. Its use aims to accelerate the development of new drugs, improving the effectiveness of tuberculosis treatment. In this context, azasugars have been studied as possible drugs for the treatment of tuberculosis, due to their ability to inhibit the enzyme maltosyltransferase (GlgE), essential for the survival of Mycobacterium tuberculosis. Furthermore, azasugars have low toxicity and high selectivity, increasing their therapeutic efficacy. In this sense, in the present work we describe the study of three series of azasugars with the aim of evaluating their potential as anti-tuberculosis drugs targeting GlgE. The results point to a compound, called A532 in this study, as a substance of pharmacological interest for this purpose, due to its favorable interaction with the active site of the enzyme, explained by the existence of a network of π interactions and hydrogen bonds. Furthermore, the results presented provide further information about the structure of possible GlgE-inhibiting azasugars and their relationship with the residues that make up its active site.
A cartografia escolar na produção acadêmica em geografia e educação: uma análise das pesquisas brasileiras realizadas entre 1995 e 2020
(Universidade Federal de São Carlos, 2023-11-13) Castanha, Rafael da Silva; Tozi, Fabio; https://lattes.cnpq.br/1239744709191702; https://orcid.org/0000-0003-1448-8353; https://lattes.cnpq.br/0633454591433310; https://orcid.org/0009-0009-2466-2555
In this dissertation, we conducted a research categorized as state of the art, which included the survey and classification of works on School Cartography produced by postgraduate programs (stricto sensu) in Geography and Education in Brazil, between 1995 and 2020. This is an investigation developed through the quantitative methodology of a descriptive nature, supported by the use of descriptors and filters available in the CAPES Catalog of Theses and Dissertations. Through this, we seek to present a historical overview of the set of production in School Cartography, according to the respective thematic axes disseminated in the Brazilian context, since the consolidation of this area of research as an academic field, with the first colloquia on cartography for children and schoolchildren held by several universities in the country. The theoretical basis was based on the contributions of the main authors and reference authors in the areas of Education, School Geography and School Cartography. Among the main conclusions of this study, we highlight that School Cartography has gained greater notoriety in the academic field, as productions become more dynamic and aim to understand the processes of reading and representing space in the school environment, from different perspectives and theoretical methodological analyses. However, it was also possible to verify that research in School Cartography, both in the area of Geography and Education, is still intensely concentrated mainly in universities in the Southeast, South and Central-West of the country, while in the other regions, productions are scarce or even non-existent.
Optimizing resetting of superconducting qubits
(Universidade Federal de São Carlos, 2023-11-13) Diniz, Ciro Micheletti; De Assis, Rogério Jorge; Almeida, Norton Gomes de; Villas-Bôas, Celso Jorge; https://lattes.cnpq.br/3102671365275808; https://lattes.cnpq.br/7703787869253387; https://lattes.cnpq.br/3182841849332242; https://lattes.cnpq.br/5700887540085418; https://orcid.org/0000-0002-7602-0468; https://orcid.org/0000-0003-1133-6012; https://orcid.org/0000-0001-8517-6774; https://orcid.org/0000-0001-5622-786X
Estudo da detecção de cédulas falsas da segunda família do Real Brasileiro através de técnicas de processamento de imagens
(Universidade Federal de São Carlos, 2023-11-13) Betti, Rafael Roiz Moyses; Barcellos, Robson; https://lattes.cnpq.br/9844506370403162; https://orcid.org/0000-0002-6009-4825; https://lattes.cnpq.br/8819521688824482; https://orcid.org/0009-0006-1456-516X
With the advent and creation of a oficial currency for the national territory, attempts do defraud Brazilian paper money and forge new ways to counterfeit it also emerged, which only grow and evolve over the years. In this way, considering the utmost importance of money for the functioning of the economy and society as a whole, it i salso necessary to validadte it properly and combat attempts at counterfeiting, both by human operators and automatically. This paper proposes a system capable of automatically separating and classifying Brazilian Real bills from the Second Family into a group of counterfeit bills and another group of genuine bills. For this, five security features of Brazilian paper money are selected, namely the “Watermark”, “Color-Changing Number”, “Holographic Strip”, “Hidden Number”, and “Fluorescent Elements”, studied individually using different image acquisition and processing techniques, image mathematical analysis, and the determination of a classification criterion. The methodology chosen for this study uses MATLAB and takes into account methods used in other works published from the perspective of Indian currency. This experiment presented na accuracy of 100% for four of the five security features tested, and 75% for the last, which led to the discussion of future suggestions for development and improvement for the Project, also exposed in this paper.
Formação de Ilhas de Calor Urbano em áreas industriais
(Universidade Federal de São Carlos, 2023-11-13) Arruda, Angela Maria de; Masiero, Érico; https://lattes.cnpq.br/2691827106518167; https://lattes.cnpq.br/5320646745445483
The impact of urbanization and industrialization on the natural environment has aroused the interest of many researchers since the end of the 19th century, when the increase in urban air temperature compared to the rural environment. This phenomenon called Urban Heat Island (UHI) impacts the thermal comfort of individuals, health problems, in air pollution and greater energy demand. The main objective of this thesis was recording the thermal behavior, occurrence and configuration of UHIs caused by the implementation of industrial zones in the urban microclimate. From the analysis systematically, it can be identified that soil use and temperature (LST) are largely explored in work on and remote sensing appears as a method most widespread, followed by computer modeling and simulation. When comparing two industrial districts of different cities, Sintra/PT and Uberlândia/BR, using the software ENVI-met and principal component analysis, it was found that the impact of ventilation in the cooling of industrial districts overlaps with factors such as the percentage of vegetation of the studied site and the albedo, capable of increasing 1.5oC in the industrial environment of Sintra when there is a reduction in wind speed of 1.9 m/s. It was verified need to expand the study, beyond the interrelationship between Tar and LST, considering other microclimatic variables such as wind speed (WS) and direction (WD), sky seeing factor (SVF), rate of kinetic energy (TKE), relative humidity (RH) and air specific (Uesp). Tar and RH were collected in situ in a residential section (R) and another industrial (DI), in the city of Uberlândia/MG, for 15 days for validation of the computational model. Tar throughout the 24 simulated hours remained higher in DI if compared to the residential section, reaching up to 1.3o C higher in the early morning. A higher vegetation rate present in the DI was not able to overcome the effect of the high rate of waterproofing by asphalt and the roofs of the large warehouses, made up of tiles uncoated metals, which tend to retain heat and have thermal emissivity low. Data from the A 507 meteorological station located at the airport of Uberlândia to estimate UHI intensity, with UHI intensity in DI being 70% higher than the residential segment. The conclusions obtained point to the difficulty of implementation of traditional mitigating measures in industrial districts, whether for limitation of physical space or feasibility of necessary interventions. Actions like replacement of construction materials already implemented by materials with properties adequate thermal temperatures, present themselves as viable alternatives to mitigate the effects of UHIs, mainly regarding the increase in nighttime Tar in industrial districts studied. Urban planning focused on the orientation of streets and avenues to optimize the circulation of winds, and allow penetration into the urban fabric, as well as the increase of the albedo of roofs and floors, can also be interesting alternatives for the mitigation of UHIs in industrial areas. The application of acrylic paints in roofs and surfaces of buildings, or the replacement of parking lot floors and maneuvering yards with permeable floors and open spaces are also alternatives that should guide construction guidelines for industrial districts, especially in cities with tropical climate. The integration between urban planning, on the part of the administration public sector, and companies present in DIs, can transform in the long term, the process of occupation of urban industrial zones focused only on optimizing production industrial. Initiatives that involve public authorities, the population affected by the conditions deteriorated thermal comfort and the interests of industries must converge towards establish processes that effectively integrate such spaces into the urban environment of the point from a climatological point of view. Transformations in urban district planning concepts Industrial industries must contribute to thermal relief and mitigate the effects of UHI in cities.
Movimentos de renovação política e juventude: sentimentos partidários e democracia em cheque
(Universidade Federal de São Carlos, 2023-11-13) Campos, Daniele Olimpio de; Kerbauy, Maria Teresa Miceli; https://lattes.cnpq.br/4762029784021248; https://orcid.org/0000-0002-0622-1512; https://lattes.cnpq.br/0922683205785588; https://orcid.org/0009-0009-2391-348X
Aren't young people responsible for the future of our country? Inspired by this question, the research carried out here aims to analyze how young people belonging to Political Renewal Movements understand and participate in Brazilian democratic processes, and above all, how they perceive the crisis of political representation and partisan sentiments. To this end, a case study was carried out focusing on the analysis of two Renovation Movements, Bancada Ativista, and RenovaBR, chosen because they concentrate young participants from multiple ideological and partisan aspects. This study is divided into three phases, including the cataloging of all participants and former participants of the respective movements and the carrying out of semi-structured interviews with young people from the chosen organizations. Furthermore, from the literature research, conceptual elements were added to understand the entire context of the creation and development of Political Renewal Movements in Brazil and their relationships with Brazilian youth.