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Imunoterapia baseada em Bacillus Calmette-Guérin (BCG) recombinante para o tratamento de câncer de bexiga em modelo murino
(Universidade Federal de São Carlos, 2024-02-01)
Delechiave, Daniela
;
Lessinger, Ana Claudia
;
https://lattes.cnpq.br/4643624035602601
;
https://orcid.org/0000-0002-2719-9457
;
Moreno, Ana Carolina Ramos
Bladder cancer is the 10th most common and 13th most deadly cancer in the world. Approximately 75% of diagnosed bladder tumors are non-muscle invasive, and transurethral resection followed by instillation of Bacillus Calmette-Guerin (BCG) is recommended as treatment. To increase the adjuvant potential of BCG, our research group developed a recombinant BCG strain (rBCG) expressing detoxified pertussis toxin S1 (rBCG-S1PT). Previous results from the group showed that mice with bladder tumors treated with rBCG-S1PT had longer survival than mice treated with native BCG. However, little is known about the immune response associated with this anti-tumor protection. In this project, we set out to characterize the anti-tumor effect promoted by rBCG-S1PT in a murine model of heterotopic bladder tumors. To this end, murine urothelial carcinoma cells (MB49) were implanted subcutaneously into the direct flank of female C57BL-6 mice (day "zero" - D0), which were then treated with three cycles of immunotherapy (BCG or rBCG-S1PT) via the peritumoral/intratumoral route on day 1 (D1), D8 and D15. Tumor volume was measured throughout the experiment to assess tumor progression. Seven days after the last treatment (D22), mice were euthanized to collect tumors and spleens to assess the immune response of these anatomical sites. As previously observed, the rBCG-S1PT strain showed greater tumor control potential compared to the parental BCG. Using flow cytometry, we analyzed the immune populations in the spleen and tumors and observed a better inflammatory response induced by rBCG-S1PT compared to the BCG group and the untreated group, with emphasis on 1) a lower frequency of regulatory T cells in the spleen and tumor; 2) a greater activation of CD4 and CD8 T lymphocytes in the spleen and tumor. 3) higher frequency of mature and activated NK cells in the spleen. Our results suggest that immunotherapy with rBCG-S1PT positively modulates the response of T lymphocytes and NK cells while controlling the immunosuppression mediated by regulatory T cells, resulting in the potentiation of the immunotherapeutic effect of rBCG-S1PT in tumor control.
Os jovens, a ciência e a biodiversidade: um estudo dos interesses de estudantes a partir de um recorte de um município do interior de SP
(Universidade Federal de São Carlos, 2024-02-01)
Marcelino, João Vítor de Andrade
;
Silva, Fernanda Keila Marinho da
;
https://lattes.cnpq.br/6390725197649567
;
Alitto, Renata Aparecida dos Santos
;
https://lattes.cnpq.br/5032799058159962
The aim of this final course project was to collect data on the interests of students from a city in the interior of the state of São Paulo in relation to biodiversity education. This study is an excerpt from a larger and more comprehensive project entitled “BIOTA-FAPESP Program in basic education: possibilities for curricular integration”, which aimed to develop teaching actions about Brazil's biological heritage. As part of an ongoing effort to characterize young students' perceptions of science and technology, the project identified data indicating a low level of interest in local biodiversity among students in southeastern Brazil. This data is consistent with other research findings that also indicate a low level of knowledge on this topic among this group of students. In this sense, trying to understand the interests of these students in order to support future educational actions would be an alternative to overcome this indifference to the topic. In this way, a quantitative questionnaire, known as the Brazil Barometer, was used to assess young people's attitudes towards science and technology. The survey was conducted in the second semester of 2022 at three different schools, with 138 students aged 15 participating. The results suggest that there is a high interest in human biology content, such as the study of diseases and medicinal herbs, as well as a high willingness to learn about plant, animal and microscopic diversity through the lens of danger and curiosity. Given these data, it is necessary to reflect on pedagogical alternatives that make the teaching of biodiversity more interesting for students and allow them to obtain enough information to develop an effective attitude towards the protection and conservation of the local environment.
Síntese de nanopartículas de ZrO2/SO42- e ZrO2/Fe3+ por método solvotérmico e aplicação na catálise de reações de esterificação
(Universidade Federal de São Carlos, 2024-02-01)
Pegoraro, Guilherme Manassés
;
Mambrini, Giovanni Pimenta
;
https://lattes.cnpq.br/7723027354150918
;
https://orcid.org/0000-0001-8943-5876
;
https://lattes.cnpq.br/3064841153326789
With the advent of nanotechnology and the production of nanostructured materials, research in recent decades has identified that it is often possible to improve the physical-chemical properties of materials by changing their scale. Zirconium oxide (ZrO2), studied in this work, presents catalytic properties for some chemical reactions. When producing nanoparticles of this material, the specific surface area is increased, where catalysis occurs. Among the catalyzed reactions, esterification stands out, which is relevant to produce biodiesel as a renewable alternative to fossil fuels. Pure, sulfated or iron(III) doped zirconium oxide were synthesized by the solvothermal route with and without microwave incidence. Both synthesis routes allowed obtaining powders with similar yields, and sulfate functionalization was confirmed by Fourier transform infrared spectroscopy (FTIR). This technique also provided evidence that the washing steps were not able to eliminate all the organic residue adsorbed on ZrO2. Scanning electron microscopy (SEM) and dynamic light scattering (DLS) results indicated that the material was highly agglomerated, but that there were particles smaller than a few micrometers. After analysis by energy dispersive X-ray spectroscopy (EDS), there was a strong indication of the formation of the desired material, as well as the presence of iron(III) as a dopant and the presence of carbon and chlorine in the material, coming from the synthesis route. X-ray diffractometry (XRD) showed that the samples synthesized on the heating plate crystallized in the tetragonal structure with an average crystallite size varying between 2 and 7 nm, while with microwave incidence there was an amorphous structure. The ideal calcination parameters were determined with the XRD technique, noting that calcination for 30 minutes at 500 ºC was enough for crystallization in the tetragonal phase, doubling the crystallite size of some samples, varying between 7 and 16 nm, in addition to eliminating the adsorbed residues. The nanoparticles were applied in the catalysis of the esterification between oleic acid and methanol or ethanol at 60 ºC. The conversion rates were determined through the elaboration of calibration curves and the deconvolution of carbonyl peaks in the infrared spectra of the reaction products. Catalytic activity was noted for practically all pure, functionalized and doped samples, with iron(III) doped samples having the best performance, such as ZrO2/Fe3+ sample produced with the heating plate, with 86.3% conversion.
Um estudo sobre diferentes arquiteturas para aplicações mobile na nuvem
(Universidade Federal de São Carlos, 2024-02-01)
Cardozo, João Vitor Fidelis
;
Lucrédio, Daniel
;
https://lattes.cnpq.br/9090396559596221
In the current technological scenario, there is a significant demand in the software market for the development of applications, whether they are web or mobile. With the emergence of cloud computing, a variety of architectures with different proposals and technologies have also been revealed. This panorama offers system developers access to various technological combinations, raising questions about the choice of the best set and consequently, the construction of the best architecture. The objective of this research was to analyze and compare three different software architectures for mobile applications prepared to be hosted in the cloud, focusing on specific evaluation criteria. Initially, the evaluation was carried out in terms of modifiability, that is, the software's capacity to be modified or adapted to specific situations was measured, for example, the need to include a non-existent field in the relational and non-relational database. Subsequently, the software's reliability was evaluated with an emphasis on fault tolerance, analyzing how the product maintains the consistency of information in the presence of potential issues. Finally, security, focused on confidentiality, was also investigated to understand the degree to which the system ensures that data is exclusively accessible only to properly authorized individuals. This study also considered the advantages of having one's own back-end and the use of a messaging service, although these criteria were not analyzed with the same systematic rigor as the others. Thus, after making comparisons based on the established criteria, results were obtained that empirically describe the positive and negative aspects of each proposed architecture, in order to provide choices based on these aspects, thus assisting in the decision on which architecture to use in the software development process for mobile devices with cloud technologies. Overall, the results of the comparison indicated that direct access to a managed storage service, such as Google Firebase's Firestore, enhances modifiability and offers more efficient management for handling request failures, in addition to ensuring the confidentiality of user information. On the other hand, the use of one's own back-end provides total control over the infrastructure and code, as well as optimizing the application's long-term costs. Finally, it is highlighted that the use of a messaging service can provide greater scalability and high data availability.
Escola em tempos de pandemia: atendimento de crianças com transtorno do espectro autista
(Universidade Federal de São Carlos, 2024-02-01)
Santos, Tatiane Cristina Gomes Franco dos
;
Camargo, Andréia Regina de Oliveira
;
https://lattes.cnpq.br/0936098182171676
;
https://orcid.org/0000-0002-1158-2814
;
https://lattes.cnpq.br/2560680553730336
This course completion work seeks a reflective approach to education in times of the Covid-19 pandemic and its consequences in the learning process of students with au-tism spectrum disorder (ASD). Bringing a rensino remoto emergencialing about the impact of the pandemic on school education and the implementation of remote educa-tion systems through platforms for online classes. The text also contains a brief presen-tation about autism in its clinical, legal and educational aspects. As well as a personal report from the mother of an autistic student who experienced school education during the pandemic period and the operation of remote classes. Finally, this work considers the importance of school for students with ASD in its face-to-face model, strengthening relationships of inclusion, socialization, association and insertion of autistic people in the space they experience on a daily basis.
O novo Ensino Médio: na teoria e prática
(Universidade Federal de São Carlos, 2024-02-01)
Moreno, Lucas Barros Zanoni Lopes
;
Seixas, Wladimir
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https://lattes.cnpq.br/1697352974728327
During an intense process of curriculum reformulation following the approval of the National Common Core Curriculum (Base Nacional Comum Curricular (BNCC)), this monography seeks to understand the main changes for a secondary school mathematics teacher and how they can prepare for them. As a teacher in training, I had the opportunity to engage in various teaching practices during internships, where I observed both teachers and students facing challenges in adapting to the new curriculum proposal. Therefore, based on a literature review and practical teaching experience, this work will present a brief history leading to the conception of the BNCC, the key changes for a mathematics teacher outlined in the curriculum, challenges in teaching mathematics, potential alterations to the proposal, a focus on the National Common Base for Teacher Training (Base Nacional Comum para Formação de Professores (BNC-F)), an exploration of active mathematics methodologies emphasized by the BNCC, and, finally, the planning and implementation of a practical teaching experience in modeling with a 1st-year High School class in a public school in São Carlos - SP.
Estudo ecotoxicológico do glufosinato de amônio em Eisenia andrei (Bouché, 1972)
(Universidade Federal de São Carlos, 2024-02-01)
Silva, Rafaela Oliva da
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Monquero, Patricia Andrea
;
https://lattes.cnpq.br/2766526793830455
In the context of the growing use of pesticides, especially glufosinate ammonium, in the face of weed resistance to herbicides and the development of transgenic crops tolerant to glufosinate ammonium, which have significantly increased its importance in agriculture, it is crucial to understand the consequences of its application and its potential threat to ecosystems, particularly terrestrial ecosystems. The species Eisenia andrei is often used in ecotoxicological studies due to its ecological importance in maintaining soil structure and fertility and its sensitivity to contaminants. This study aimed to evaluate the ecotoxicological effects of the herbicide glufosinate ammonium on earthworms of the species Eisenia andrei (Bouché, 1972), focusing on aspects of acute, chronic and behavioral ecotoxicity. The tests were conducted in accordance with International Organization for Standardization (ISO) standards (11268-1, 1993; 11268-2, 1998; 17512-1, 2008). All tests used a completely randomized design (DIC), with six concentrations of the herbicide glufosinate ammonium (acute: 0, 175, 340, 505, 670 and 835 mg i. a. kg-1; chronic and behavioral 0, 3.3; 5; 6.7; 8.3 and 10 mg i.a. kg-1) and four replicates for the acute and chronic tests and five replicates for the behavioral test. The results showed significant impacts on the survival, biomass, reproduction and behavior of the earthworms at certain concentrations. The Median Lethal Concentration (MIC) for 14-day mortality was set at 611.68 mg i.a. kg-1, indicating moderate toxicity to the herbicide. The Median Effective Concentration (MIC) for effects on reproduction in 56 days and for inducing escape in 48 hours were set at 4.49 mg i.a. kg-1 and 3.30 mg i.a. kg-1, respectively. The concentrations of 8.3 and 10 mg i.a. kg-1 induced the greatest escape responses, but did not reach the 80% escape threshold established by ISO 17512-1 for classifying a substance as toxic. These findings highlight the importance of assessing the ecotoxicological risks of pesticides such as glufosinate ammonium for safer and more sustainable agricultural management practices.
A reforma trabalhista de 2017 e suas implicações para a ocupação, renda e vulnerabilidade social no Estado de São Paulo de 2017 a 2021
(Universidade Federal de São Carlos, 2024-02-01)
Pantiga, Ariana Cassioti
;
Santos, Leandro de Lima
;
https://lattes.cnpq.br/2750978055015275
;
https://orcid.org/0000-0001-8413-5372
This undergraduate thesis in the field of Administration focuses on the Labor Reform of 2017 and its implications for occupation, income, and social vulnerability in the state of São Paulo, from 2017 to 2021. The main objective of this study is to analyze the impacts of the changes inlabor legislation in 2017 on the job market in São Paulo, considering the perspective of occupation level, income, and social vulnerability. To achieve this, a methodology was employed, including a literature review on the subject, documentary analysis of laws and regulations related to labor reform, and statistical analysis of secondary data concerning the jobmarket in the state of São Paulo. The guiding question of this research is: What is the impact ofchanges resulting from labor legislation on the job market in the state of São Paulo, considering the implications for occupation level, income, and social vulnerability between 2017 and 2021? Based on this central question, efforts were made to identify the main changes brought about by labor reform and how they directly affected workers in São Paulo. This work contributes to the discussion on labor reform and its social impacts, providing a detailed overview of the job market in São Paulo during the analyzed period. The findings highlight the need for public policies that promote social justice and reduce inequalities in the job market.
Tecnologia e intervenção precoce: produção de vídeos para o apoio às práticas centradas na família no Brasil
(Universidade Federal de São Carlos, 2024-02-01)
Silva, Camila Larissa Vaz
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Arini, Bruna Pereira Ricci
;
https://lattes.cnpq.br/2001819857612181
;
Della Barba, Patrícia Carla de Souza
;
https://lattes.cnpq.br/6448489426438006
The present study aimed at the technological production of audiovisual materials (videos) based on the Practical Guides for the Family from the Early Childhood Technical Assistance Center, for submission to its website and also for availability for use in early intervention services in Brazil. Considering the recognition of childhood as a period of greater neural plasticity and acquisition of important skills for later stages of people's lives, the process of early intervention is necessary to provide better development for children who are or may be at risk of developmental delays. Recognizing the importance of the family in the process of child development, Family-Centered Practices are considered more potent, as they view the family as an active member of the team, involving them in the process. Thinking about Family-Centered Practices in early intervention services, a set of guides and checklists were developed at the Early Childhood Technical Assistance Center at the University of North Carolina - Chapel Hill, based on evidence, to guide professionals and families on recommended practices and expected outcomes. These lists and guides are available on the Early Childhood Technical Assistance Center website in areas recognized by the Division of Early Childhood, where the Practical Guides for the Family include explanatory videos about their use. Assuming that Family-Centered Practices are not yet well disseminated in Brazil, the materials were translated into Portuguese (Brazil), aiming to integrate the country into this more current context of early intervention. However, considering that videos are an important tool for understanding for families and early intervention professionals, there was also a need to bring them into the Brazilian context and language, contributing to the dissemination of such practices in Brazil. Therefore, this work aimed to contribute to the advancement of Family-Centered Practices in early intervention services in Brazil, offering its products as a means for professional practice. It is a study of translation and adaptation of audiovisual materials, developed based on the survey of guides and videos that align with the objectives, followed by the translation and production of new videos with audiovisual materials provided by early intervention services that meet the requirements of this work and agree to participate. As a result, more than 90% of the foreign audiovisual material was adapted, which is considered a satisfactory outcome considering the objective of this study.
Aplicação de Técnicas de Aprendizado de Máquina na Identificação de Marcadores Genéticos para a Doença de Alzheimer
(Universidade Federal de São Carlos, 2024-02-01)
Alves, Juliana Ferreira
;
Cerri, Ricardo
;
https://lattes.cnpq.br/6266519868438512
;
https://orcid.org/0000-0002-2582-1695
;
https://lattes.cnpq.br/0104274733044968
Single nucleotide polymorphism (SNP) is the variation at a single position in the nucleotide chain where DNA is formed. Since it is a genetic alteration, it is of utmost importance for the study of human health. Through it, it is possible to predict individuals' responses to certain medications, search for genes related to hereditary diseases in a family group, and it can also be associated with more complex diseases such as cardiovascular diseases, diabetes, cancer, and Alzheimer's Disease. With the use of supervised Machine Learning, it is possible to conduct studies on the relationship between SNPs and complex diseases, with each SNP being an input variable for such algorithms. Thus, the aim of this project was to investigate the relationship between SNPs and Alzheimer's Disease, through Machine Learning algorithms. For this purpose, datasets of individuals and their respective SNPs and diagnoses (Normal, Mild Cognitive Impairment, or Alzheimer's Disease) were used. Therefore, this study presents an innovative approach to identifying genetic markers associated with Alzheimer's Disease (AD), combining machine learning techniques and genomic analysis into a set of four crucial steps. The first step consists of data preprocessing and normalization, followed by the implementation of Genome-Wide Association Studies (GWAS) on all datasets generated in the previous phase. The third step employs advanced machine learning methods on the most promising dataset identified in the previous steps. Finally, the fourth step involves a comparative analysis of the results achieved in the GWAS and machine learning stages. The results of this study revealed a comprehensive set of SNPs associated with AD, including both those previously known in the scientific literature and promising new discoveries. Furthermore, the importance of data handling in quality control was highlighted, which had a significant impact on the results obtained. The machine learning models used in this study showed distinct profiles of the most significant SNPs, emphasizing the complexity and heterogeneity of AD. This variation in coefficients and feature importances underscores the need for an integrated and multifaceted approach to AD genetics research. In summary, this study demonstrates the potential of machine learning and genomic analysis in advancing knowledge about AD. The results provide new insights into the emerging field of AD genomics, opening up new perspectives for more effective therapeutic and diagnostic strategies. The findings presented represent a significant advancement towards a deeper understanding of AD genetics and its impact on human health.
Um estudo sobre sistemas de amortização
(Universidade Federal de São Carlos, 2024-02-01)
Santos Filho, Cesar Balbino dos
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Peixoto, Magda da Silva
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https://lattes.cnpq.br/0413910306376054
Este trabajo muestra una visión detallada de las simulaciones de amortización de financiamiento inmobiliario realizadas por bancos, especialmente Caixa Econômica Federal y Banco do Brasil. Discriminar los cálculos uno a uno a través de conceptos matemáticos y el uso de hojas de cálculo electrónicas que están a disposición de la sociedad y facilitan la rutina de las personas.
Levantamento do meio físico e classificação de terras pelo Sistema de Capacidade de Uso do Solo no CCA/UFSCar
(Universidade Federal de São Carlos, 2024-02-01)
Lima, Maria Isabel de Oliveira
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Oliveira, Anna Hoffmann
;
https://lattes.cnpq.br/6666918682171234
;
https://orcid.org/0000-0002-5479-8359
;
https://lattes.cnpq.br/3053038876503434
Investigating the natural propensity for land use is extremely important, especially in environments subject to intense human action. When the soil's productive capacity conditions are not taken into account, and it is used inappropriately, underutilization or overutilization may occur, resulting in inefficiency or severe damage. From this perspective, the objective of the work was to determine the land use capacity at the Agricultural Sciences Center (CCA) of the Federal University of São Carlos (UFSCar), Araras campus. The potential of the land was assessed through information on the morphological, physical and chemical attributes of the soil made available in the CCA's detailed pedological survey, in addition to the ultra-detailed planialtimetric survey and field observations. The classification method adopted was the Land Use Capability System, which considers effective depth, texture, permeability, specific limiting factors, slope, erosion and current use, among others, in order to identify soils according to their greatest limitation. Based on the analyses, maps of current land use, land use potential and land use suitability were created. It was found that the entire area falls into Group A, whose intensity of use accommodates annual and perennial crops, pastures, reforestation and wildlife. There are, however, differences regarding soil conservation needs, verified between the classes present. On the campus there is a predominance of class III (94.14% of the total area of classified land), indicating areas prone to complex conservation and/or improvement problems; in class II, with simpler problems, there is 2.31%; with the remainder (3.54%) presenting serious problems related to soil conservation. In addition to the 23.78% of the total area of classified land occupied by Permanent Preservation Area (APP) and Legal Reserve (RL), in more than half of the area (67.59%) the land use is adequate to its capacity. There is usage above and below capacity at 3.54% and 5.09%, respectively. Regarding the sustainability of land use in the CCA/UFSCar, it is recommended for overused areas, currently under sugarcane cultivation, the adoption of less intensive soil management, depending on their limitations, or even the allocation of area for conservation, in addition to the implementation of recovery and erosion control practices. Underutilized soils, on the other hand, can be exploited to their maximum potential, which includes annual cultivation and more intensive management. For soils that are in their appropriate use, it is recommended the adoption and/or maintenance of conservation practices, due to the predominant use capacity class (III) on the campus, in order to guarantee sustainable management of the soil resource and the prevention of degradation of water resources.
O latifúndio como forma e a exclusão como regra: obstáculos à reforma agrária no Brasil a partir do caso do acampamento Quilombo Campo Grande
(Universidade Federal de São Carlos, 2024-02-01)
Corrêa Junior, Jadir Eduardo
;
Aly Junior, Osvaldo
;
Carvalho, Joelson Gonçalves de
;
https://lattes.cnpq.br/2861397369412900
;
https://lattes.cnpq.br/9927342599524750
Este artigo se propõe a investigar a luta pela terra das famílias acampadas no Quilombo Campo Grande, localizado em Campo do Meio, Minas Gerais, com o intuito de lançar luz aos desafios e barreiras que essas famílias enfrentaram ao lutar por terra e pela reforma agrária no Brasil. Partimos do pressuposto que o estudo de caso em questão ilustra e representa de forma concreta, as dificuldades e obstáculos inerentes à concretização de políticas de reforma agrária no país. Para alcançar os objetivos da pesquisa, optou-se por uma abordagem metodológica que combina o método histórico estrutural com o materialismo histórico-dialético. No que se refere aos procedimentos metodológicos, a pesquisa se valeu de revisão bibliográfica, análise documental, observação participante e entrevistas narrativas em profundidade. Esse estudo busca dar visibilidade às complexas dinâmicas envolvidas na luta pela reforma agrária no Brasil, demonstrando como a propriedade da terra é intrinsecamente ligada ao poder e às questões econômicas e políticas do país. As conclusões indicam que há inegável emaranhamento dos poderes constituídos, a saber: executivo, legislativo e judiciário ao poder financeiro dos grandes proprietários de terra, gerando o entendimento do que é função social da propriedade, presente na Constituição Federal de 1988, seja subvertido
MC Daleste - Mataram o Pobre Loco: análise do documentário Globoplay no contexto da plataformização do audiovisual
(Universidade Federal de São Carlos, 2024-02-01)
Ferreira, Guilherme Belarmino
;
Massarolo, João Carlos
;
https://lattes.cnpq.br/3308336910966465
;
https://orcid.org/0000-0001-5083-1601
;
https://lattes.cnpq.br/2058041487349115
The study examines the narrative, aesthetics, and themes of the documentary "MC Daleste - Mataram o Pobre Loco" (2024), an original production by Globoplay in the true crime genre which investigates the unresolved 2013 murder of the funk singer MC Daleste. The research reflects on the relevance of the true crime genre in the scenario of competition among national and global platforms, known as the Streaming War, and analyzes Globo's strategic shift in producing and distributing audiovisual content in the context of digital convergence and platformization. By tracing the origins and providing a historical overview of Globo's evolution from a television content producer and broadcaster to a mediatech company—a company that leverages technological tools and platforms to produce, store, and distribute content while collecting and analyzing data to adapt to changing consumer behaviors and maintain relevance—the author highlights the documentary's role as a vital tool for audience acquisition and retention in the streaming era. The conclusion suggests that evolving consumption habits are likely to drive documentaries to increasingly adopt narrative, aesthetic, and promotional techniques commonly associated with fictional cinema.
Isolantes refratários avançados para alta temperatura
(Universidade Federal de São Carlos, 2024-02-01)
Silva, Vinicius Ferro
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Pandolfelli, Victor Carlos
;
https://lattes.cnpq.br/7369376873984839
;
https://lattes.cnpq.br/9065704301303821
The objectives of this work encompass the production of non-sintered ceramic insulating foams and their application as a hot-face lining in high-temperature furnaces. To achieve this, a specific insulating ceramic composition was developed, and its properties were evaluated in the green and post-sintering states. The results were compared with the literature and indicated that the approach adopted in this work, associating the direct foaming process with the application of green foams, allowed for an innovative approach to various issues in today's society. The in-situ sintering of ceramic foams has the potential to change the current scenario of refractory insulation, considering that this processing step is the most costly in terms of energy, economy, and environment. Furthermore, the Al2O3-CaO system of the ceramic foams in this work presents considerable advantages when compared to the current Al2O3-SiO2 fiber-based composition of commercially available materials, significantly increasing the durability of insulating linings and the thermal efficiency of high-temperature furnaces. This study confirmed these concepts by verifying the good insulating performance of the green ceramic foams installed as a hot-face lining in the Lindberg Blue M furnace at the Alcoa-GEMM laboratory as a proof of concept.
Projeto e implementação de um ambiente de capacitação em computação em nuvem com virtualização
(Universidade Federal de São Carlos, 2024-02-01)
Oliveira, Miguel Antonio de
;
Guardia, Hélio Crestana
;
https://lattes.cnpq.br/1780902767520967
;
https://lattes.cnpq.br/9185884864965247
OpenStack-based cloud computing platforms are notoriously complex to deploy, requiring the efforts of operators who are familiar with the process and its interactions with the surrounding environment. In particular, environments designed around the training of new operators suffer from high demand of new deployments for use in practical experimentation. With that in mind, the deployment process, as well as applicable automation techniques, are analyzed, aiming to simplify workflows and increase the efficiency of environments which require redeployment without human interaction, with a particular focus around OpenStack clouds hosted on other cloud platforms. Insights are gathered around the procedure and automation tool usages, future usage suggestions, and how these influenced the built environment’s final state.
Fragilização por hidrogênio da liga Ti-6Al-4V ELI: métodos de hidrogenação e caracterização mecânica
(Universidade Federal de São Carlos, 2024-02-01)
Borrut, Loïc Serrigny
;
Koga, Guilherme Yuuki
;
https://lattes.cnpq.br/0933095081175012
;
Bolfarini, Claudemiro
;
https://lattes.cnpq.br/9231627080617037
Titanium alloys are highly valued materials due to the combination of various commercially relevant properties, including high specific strength and corrosion resistance, a high melting point, and ductility. The versatility of properties exhibited by these alloys, especially Ti-6Al-4V alloys, makes them attractive for a range of applications, even sparking interest for potential use in offshore oil exploration structures. However, titanium alloys are susceptible to hydrogen embrittlement when exposed to environments containing high concentrations of hydrogen. Structural materials in maritime environments are typically subjected to cathodic protection by impressed current to prevent corrosion. A potential side effect of cathodic protection is the release of hydrogen at the interface between the protected metal and the electrolyte in contact with it, due to hydrogen evolution reactions, which can lead the protected metal to absorb significant amounts of hydrogen. This is a possible limiting factor for the use of titanium alloys in maritime structures. This study aimed to investigate the influence of hydrogen presence on the static mechanical properties of Ti-6Al-4V ELI alloy, especially ductility, to evaluate the susceptibility of this alloy to hydrogen embrittlement. For this purpose, specimens of the study material were subjected to hydrogenation processes for different periods, and subsequently, their mechanical properties were determined through a low-strain rate tensile test. The results of the tensile tests, however, were similar for the non-hydrogenated material and the specimens hydrogenated for different periods, indicating that the hydrogenated specimens did not absorb sufficient amounts of hydrogen to cause embrittlement under the hydrogenation conditions applied in this study.
Implicações das relações interprofissionais no trabalho da (o) enfermeira (o) da Atenção Primária à Saúde
(Universidade Federal de São Carlos, 2024-02-01)
Valle, Carla Cristina Del
;
Silva, Jaqueline Alcântara Marcelino da
;
https://lattes.cnpq.br/8311079340428705
;
https://orcid.org/0000-0002-8307-8609
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https://lattes.cnpq.br/5920136863231272
Interprofessional relationships in the context of Primary Health Care (PHC) can be recognized from the organization of the health work process. Interprofessional practice is essential for effective, comprehensive healthcare, recognizing the health needs and vulnerabilities of the population. The nurse's role is considered to be teamwork, the articulation and coordination of care, the centrality of patient care and the identification of health needs and vulnerabilities. Objective: To understand, from the nurse's perspective, how interprofessional relationships occur in the context of PHC; how nurses recognize interprofessional work and how it influences their work; to investigate how the coronavirus pandemic has interfered with interprofessional work in PHC. Method: A descriptive, qualitative study was carried out in a medium-sized municipality in the state of São Paulo, with nurses working in PHC. Semi-structured interviews were conducted and then transcribed and their thematic content analyzed in the light of the work process and the attributes of interprofessional practice. This study followed the ethical precepts for research with human beings. Results: Interviews were conducted with twelve nurses, whose data enabled the construction of three thematic categories: the work of nurses and their role in integrated or fragmented care management: care and administrative dimensions; Interprofessionality and PHC: persistent weaknesses and difficulties; the coronavirus pandemic affecting interprofessional working relationships. Conclusion: In PHC health care, the role of the nurse stands out, with an emphasis on administrative activities in their work process. Interprofessional work is manifested through partnership, mutual support, bonding and communication, but is hampered by a lack of engagement, vertical and centralized action. The COVID-19 pandemic has altered working relationships, with workers falling ill and becoming overworked. The interprofessional collaboration to strengthen working relationships during the pandemic stands out, an aspect that requires constant investment to move towards more integrated practices.
Efeitos do uso de subdoses de herbicidas no controle de diferentes espécies do gênero Urochloa
(Universidade Federal de São Carlos, 2024-02-01)
Guidette, Luiz Gustavo
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Monquero, Patricia Andrea
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https://lattes.cnpq.br/2766526793830455
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https://lattes.cnpq.br/7885633132178730
In crop-livestock integration systems, the use of underdoses of herbicides has stood out because it makes it possible to manage forage species in consortium with corn. The aim of this study was to evaluate the treatments mesotrione + atrazine (60 + 800, 90 + 800 and 120 + 800 g a.i. ha-1), mesotrione + terbuthylazine (60 + 250, 90 + 250 and 120 + 250 g a.i. ha-1), nicosulfuron + atrazine (16 + 800 and 20 + 800 g a.i. ha-1) and nicosulfuron + atrazine (16 + 800 and 20 + 800 g a.i. ha-1). a ha-1) and nicosulfuron + terbuthylazine (16 + 250 and 20 + 800 g i.a ha-1), in subdoses, regarding the phytotoxicity observed in the species Urochloa brizantha and Urochloa ruziziensis, and in the corn crop. The experimental design was a randomized block design, 11 x 2, with 11 treatments and 2 forage species, and three replications. In the field, the corn was planted at 0.90 m spacing, with interspersed rows of forage plants, and the treatments were applied 15 days after corn emergence (DAE), thus assessing the intoxication observed in the forage plants and corn at 7, 14 and 21 days after application (DAA). At the end of planting, the heights of the ears were also measured. In the greenhouse, a completely randomized design (DIC) was used with the same treatments and the phytotoxicity of the brachiaria was analysed at 15 and 30 DAE, determining the accumulation of dry biomass of the aerial part at 30 DAA. Dose-response curves were also formulated for the herbicide terbuthylazine, in which the intoxication rates of the forage plants U. brizantha, U. ruziziensis and U. decumbens were evaluated at 15 and 30 DAE, for 7, 14, 21 and 28 DAA, and the accumulation of dry mass of the aerial part was determined at 30 DAA. The Scott-Knott test was applied to the analyses and linear regression was applied to the curves. In the field, none of the treatments showed phytotoxicity above 25% after 21 DAA, while in the greenhouse, despite the phytotoxicity associated with the doses, there was no statistical difference between the herbicides in terms of biomass loss by the forage plants. There was no damage to the height of the maize plants. For the control of Althernantera thenella and Ricinus communis in the field, the areas with U. brizantha provided better control associated with the sub-doses of herbicides than U. ruziziensis, which may indicate that this forage has adapted better to the proposed system. Terbuthylazine proved to be selective to forage crops only at 15 DAS.
Caracterização da proteína de fusão ZZ-AmyLuc e sua otimização para imunoensaios
(Universidade Federal de São Carlos, 2024-02-01)
Cavalcante, Maysa de Souza
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Silva, Jaqueline Rodrigues da
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https://lattes.cnpq.br/5385528342715589
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Viviani, Vadim Ravara
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https://lattes.cnpq.br/3942043373510668
Immunoassays are widely used in biomedical analysis based on antigen-antibody interaction, in which they are capable of detecting antibodies against specific antigens. In general, the most sensitive commercial assays mainly use chemiluminescence as a detection method. However, current chemiluminescence methods based on the enzyme horseradish peroxidase (HRP) conjugated with secondary antibody and luminol show a rapid decay of luminescence. Thus, the new fusion protein, ZZ-AmyLuc, built from the luciferase of the firefly Amydetes vivianii fused to the ZZ portion of protein A (VIVIANI et al., 2021), proved to be a good alternative. This protein has a stronger blue-green glow, with greater bioluminescent activity, in addition to being very thermostable and presenting more sustained emission, capable of lasting several minutes (t1/2 > 30 min). Furthermore, it was notably capable of detecting type G immunoglobulins (IgG), including the anti-nucleoprotein of the SARS-CoV-2 virus and its respective antigen. The detection could be observed using photodetection cameras (CCD) and even common smartphone cameras, supporting its high efficiency in both immunoassays and Western Blotting techniques. However, a more detailed physicochemical characterization of ZZ-AmyLuc had not yet been carried out, requiring its in vitro stabilization and optimization of the sensitivity of the detection assay for use in bioluminescent immunoassays, particularly for the detection of the SARS-CoV-2 nucleoprotein. For that, the kinetic properties were determined, namely the KMs for ATP and D-luciferin, the optimal pH for bioluminescent activity and IgG binding, thermostability at 4 ºC, -20 ºC and 37 ºC, as well as the optimization of the sensitivity of photometric detection assay in immunoassays.