Navegando por Data de Publicação, começando com "2025-11-05"

Filtrar resultados por ano ou mês

Agora exibindo 1 - 3 de 3

PVA Films with Carbonized Kraft Lignin: Physico-Chemical Properties and Application in Gas Detection
(Universidade Federal de São Carlos, 2025-11-05) Fré, Lucas Victor Benjamim Vasconcelos; Freitas, Amanda de Sousa Martinez de; Rodrigues, Jéssica Souza; Simõis, André Vitor Santos; Komatsu, Daniel; Oliveira, Vinicius Jessé Rodrigues; Olivati, Clarissa de Almeida; Ferreira, Marystela; https://lattes.cnpq.br/1639776120503990; https://orcid.org/0000-0001-5133-2310; https://orcid.org/0000-0001-7074-4716; https://orcid.org/0000-0002-6023-6571; https://orcid.org/0000-0002-5750-1266; https://orcid.org/0000-0002-2441-8650; https://orcid.org/0000-0001-9234-3913; https://orcid.org/0000-0002-0114-6795; https://orcid.org/0000-0002-9459-8167
Kraft lignin (KL), a major byproduct of the pulp and paper industry, is still largely underutilized, limiting its value in advanced materials. This work investigates whether incorporating carbonized kraft lignin (CKL) into polyvinyl alcohol (PVA) films can enhance their structural and functional properties and enable their use as gas-sensor membranes. PVA films containing 0, 10, 30, and 50 weight percent (wt.%) CKL were prepared and characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), water-contact-angle (wettability) measurements, and tensile testing, followed by ammonia (NH3), ethanol (C2H5OH), and toluene (C7H8) sensing. CKL increased thermal stability (temperature at 5% mass loss, T5%, up to 135 °C vs. 80 °C for neat PVA), raised carbonaceous residue to 15%, and improved Young’s modulus while reducing elongation and water contact angle. Gas-sensing tests revealed a strong, reversible current response to NH3, with PVA/50 wt.% CKL exhibiting the highest current (ca. 23 µA), along with detectable responses to ethanol and toluene. These results demonstrate that CKL is an effective bio-derived additive that upgrades PVA films for sustainable, high-performance gas-sensing applications.
“Eu sou o filho da Terra!”: educação ambiental crítica e o sujeito ecológico na relação entre escola e unidades de conservação.
(Universidade Federal de São Carlos, 2025-11-05) Lobo, Lara Bittar; Bernardes, Antonio Henrique; https://lattes.cnpq.br/6785212671844982; https://lattes.cnpq.br/3086803140941056; https://orcid.org/0009-0004-0376-2921; Rafael, Larissa Monteiro; Buck, Sonia Maria Couto; https://lattes.cnpq.br/6069182413192543; https://lattes.cnpq.br/6348498080017701
This master’s thesis investigates the challenges and possibilities of integrating Critical Environmental Education (CEE) into daily school routines, focusing on the articulation between the State School Prof. Arquimínio Marques da Silva (Sorocaba/SP) and the Ipanema National Forest (Flona Ipanema) (Iperó/SP). The study is based on the hypothesis that there is a gap in the implementation of critical environmental education principles in both formal school environments and Protected Areas (PAs), which calls for an investigation into whether mediation between these spaces can address such a deficiency. The primary objective was to analyze the effectiveness of educational practices in these institutions and propose actions to strengthen their integration through the lens of Socio-environmental Geography. Methodologically, the research is anchored in Freirean-based propositive research, utilizing focus groups with teachers and semi-structured interviews with environmental guides to diagnose the challenges presented. The theoretical framework is grounded in authors such as Loureiro, Tozoni-Reis, Porto-Gonçalves, Mendonça and Freire. The results reveal that, despite severe institutional barriers — such as curricular fragmentation, lack of time, and limited resources —, there is a genuine enthusiasm among educators to connect school content with practical experiences, as well as among environmental guides during guided trails. In response to these limitations, the research presents, in its final chapter, an Interdisciplinary Action Plan that materializes the "untested feasibility" (inédito viável), integrating skills from National Common Curricular Base (BNCC) with thematic axes linked to the Ipanema National Forest. It concludes that overcoming the neutrality of knowledge requires a praxis that transforms the Protected Area into a living laboratory of citizenship, reaffirming Environmental Education as an act of resistance and a structural principle for understanding the complexity of the contemporary world.
Vacinologia reversa e imunoinformática aplicadas à identificação de candidatos vacinais contra Enterobacter cloacae
(Universidade Federal de São Carlos, 2025-11-05) Soares, Gabriela Guerrera; Pranchevicius, Maria Cristina da Silva; https://lattes.cnpq.br/4772148921558977; https://lattes.cnpq.br/2222866375818312; Fuentes, Andrea Soares da Costa; Pitondo-Silva, André; Pranchevicius, Maria Cristina da Silva; https://lattes.cnpq.br/2426157257540389; https://lattes.cnpq.br/3539676071345227; https://lattes.cnpq.br/4772148921558977
Antimicrobial resistance associated with the Enterobacter cloacae complex represents an increasing challenge in hospital settings, especially given the scarcity of effective new antibiotics. Despite the clinical relevance of this pathogen, no licensed vaccines against E. cloacae currently exist, and the therapeutic alternatives available are becoming progressively more limited. In this context, the present study aimed to develop a multi-epitope vaccine candidate capable of inducing both cellular and humoral immune responses against conserved proteins of this pathogen, using a robust pipeline integrating subtractive proteomics, reverse vaccinology, and immunoinformatics. A total of 21 complete clinical genomes were analyzed, enabling the identification of 1,352 proteins associated with essentiality, virulence, or antibiotic resistance, which were subsequently filtered to yield 39 proteins non-homologous to the human proteome and to the gut microbiota. From these, nine promising proteins were selected, and B- and T-cell epitopes were predicted based on high binding affinity to multiple MHC alleles, non-toxicity, absence of allergenicity, and elevated immunogenic potential. These components supported the development of four multi-epitope vaccine constructs (VEC1–VEC4), among which VEC1 exhibited the most favorable characteristics, including optimal physicochemical properties, a stable three-dimensional structure, strong predicted interaction with Toll-like receptors, and an estimated global population coverage of 92.6%. Immune simulations demonstrated the vaccine’s ability to induce robust antibody production, activation of helper and cytotoxic T cells, and formation of memory cells after three simulated doses. Additionally, the VEC1 sequence was codon-optimized for expression in Escherichia coli and successfully cloned in silico into the pET-28a (+) vector, indicating feasibility for future experimental validation. The vaccine candidate developed here shows practical potential for controlling E. cloacae infections, contributing to reduced selective pressure from antibiotics and supporting efforts to combat antimicrobial resistance. These findings highlight the value of immunoinformatics as an accelerating tool in vaccine development and provide a solid foundation for subsequent in vitro and in vivo validation studies.