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Modelo aditivo de Aalen em análise de sobrevivência: estudo e aplicações
(Universidade Federal de São Carlos, 2026-06-29)
Barbosa, Júlia Vieira
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Dias, Teresa Cristina Martins
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http://lattes.cnpq.br/0187724276640668
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http://lattes.cnpq.br/6195867839835727
This paper presents a study on models in Survival Analysis, with emphasis on Cox's proportional hazards model and Aalen's additive model. Initially, basic concepts of the area, necessary for understanding the models studied, are presented. Then, Cox's model is discussed and applied to two sets of real data, allowing for the evaluation of its interpretation and the assumption of risk proportionality. Subsequently, Aalen's additive model is presented, an alternative formulation that describes the effects of covariates on the additive risk scale through cumulative regression functions. This model is also applied to two sets of real data, aiming to illustrate its interpretation and its usefulness in situations where there is interest in evaluating the behavior of effects over time. In general, the work seeks to present the interpretations provided by the two models and highlight the importance of verifying the assumptions involved in the analysis.
O Novo Ensino Médio (Lei Nº13.415/17) em Santa Catarina: flexibilização curricular e suas contradições
(Universidade Federal de São Carlos, 2026-06-29)
Vorel, Rosiclei
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Vilena, Denise Silva
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http://lattes.cnpq.br/8155152145332951
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https://orcid.org/0000-0003-2973-1301
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https://lattes.cnpq.br/1654790632544790
The Reform of Upper Secondary Education (Law No. 13.415/2017) in Brazil introduced significant changes in curricular organization, particularly emphasizing curriculum flexibilization and the expansion of students’ possibilities of choice. Within the context of this reform, Elective Curricular Components (ECCs) became part of the curricular structure of state education systems. This dissertation analyzes the configuration of these components in the state education network of Santa Catarina, focusing on the area of Mathematics and its Technologies. The study investigates how the policy of curriculum flexibilization has been translated into the normative and guiding texts of the state network, and what tensions emerge between the discourse of expanding students’ choices and the concrete conditions of implementation in public schools. This is a qualitative study, documentary and bibliographic in nature, grounded in the analytical categories of the British sociologist Stephen J. Ball, particularly the notions of performativity and control at a distance. The study analyzes national and state legislation and normative documents, such as the National Common Curricular Base (BNCC), the Law of Guidelines and Bases of National Education (LDB), Laws No. 13.415/2017 and No. 14.945/2024, as well as materials and guidelines produced by the Santa Catarina State Department of Education, taking the Elective Curricular Components (ECC) as its object of analysis. The results show that the discourse of student protagonism and the expansion of choices confronts structural limitations in schools, such as infrastructure and teacher availability, as well as the centrality of standardized materials and the intensification of teaching work. It is concluded that the ECCs express a dispute between the ideal of comprehensive public education and the managerial-corporate logic that guides the reform: the normative frameworks operate through a performative rationality, oriented toward goals, comparisons, and measurable results, marked by the rapid pace of reforms and by the individual responsabilization of schools and teachers, thereby weakening the comprehensive formative role of public schooling.
Análise da morfologia e do transcriptoma dos ovários no desenvolvimento de operárias da abelha sem ferrão Melipona quadrifasciata
(Universidade Federal de São Carlos, 2026-06-29)
Magri, Lucas Araújo
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Freitas, Flávia Cristina de Paula
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http://lattes.cnpq.br/5139566975444110
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https://orcid.org/0000-0002-3162-4890
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http://lattes.cnpq.br/3282874048124911
Eusocial bees exhibit a division of labor between queens and workers, in which the queen is primarily responsible for colony reproduction. However, in some species, workers retain the ability to produce viable haploid eggs and contribute to colony offspring, as observed in Melipona quadrifasciata. This characteristic raises questions about the molecular mechanisms and transcriptional programs that allow workers to reach adulthood with developed and functional ovaries. In this context, the present study aimed to characterize the ovaries of M. quadrifasciata workers throughout the pupal stage by integrating morphological and transcriptomic analyses. Ovaries were examined using cellular labeling and fluorescence microscopy, while the transcriptome was investigated through RNA sequencing (RNA-seq), employing differential gene expression and gene co-expression analyses to identify genes and modules associated with ovarian development. Morphological characterization revealed that the basic ovarian structures are already established during the early pupal stages, including the organization into four ovarioles, the presence of a terminal filament, and a germarium region containing polyfusomes and ring canals. Developmental progression was marked by major structural changes beginning with the onset of body pigmentation, when the vitellarium became distinguishable and contained developing oocytes associated with nurse cell chambers. Differential expression analyses corroborated this pattern, indicating that the final developmental stage exhibited the highest number of differentially expressed genes, including genes related to ecdysteroid biosynthesis, juvenile hormone pathways, and reproductive processes. Co-expression analyses revealed modules characterized by a progressive decrease in expression throughout development, with hub genes potentially involved in gene repression, chromatin remodeling, ubiquitination, and ecdysteroid biosynthesis. In contrast, a module displaying an antagonistic expression profile showed peak expression at the final developmental stage and contained genes associated with hormonal response, cell signaling, and tissue maturation. Together, these results indicate that ovary development during pupal stage in M. quadrifasciata is characterized by coordinated transcriptional reorganization associated with metamorphic hormone dynamics and the sequential activation of distinct genetic programs. This study expands current knowledge of ovarian development in stingless bees and provides evidence for the integrated involvement of hormonal, epigenetic, and cell signaling mechanisms in the formation of fertile ovaries in worker bees.
Educação CTS na formação de licenciandos do PIBID: a elaboração de uma sequência didática sobre gênero como Questão Sociocientífica no ensino de Ciências
(Universidade Federal de São Carlos, 2026-06-29)
Pacheco, Beatriz Cabral
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Lopes, Nataly Carvalho
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http://lattes.cnpq.br/0285391776145231
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https://orcid.org/0000-0002-5113-8398
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http://lattes.cnpq.br/6726237593765167
This research aimed to analyze how elements of Science-Technology-Society (STS) Education, developed within a formative process with pre-service teachers participating in the Institutional Teaching Initiation Scholarship Program (PIBID), were materialized in a Teaching Sequence designed to approach gender as a Socioscientific Issue in Science Education. The investigation was grounded in the understanding that science education cannot be restricted to the transmission of conceptual content, but should enable a critical reading of the relationships among science, technology, society, culture, and power. Methodologically, the research was developed through a qualitative approach, guided by participatory research, within the context of a formative process organized with PIBID pre-service teachers. The corpus of analysis consisted of the Teaching Sequence collectively produced by the participants and the written reflective feedback elaborated after its implementation in the school context. The analysis was guided by Content Analysis, considering categories related to STS Education, Socioscientific Issues, conceptual, procedural, and attitudinal dimensions, the approach to gender in Science Education, and the formative learning produced through the experience. The results indicated that the Teaching Sequence incorporated relevant elements of the STS/SSI perspective by articulating scientific knowledge, digital technologies, the circulation of discourses on social media, fake news, algorithms, and gender relations based on the controversy involving red pill discourses. The proposal projected formative possibilities related to argumentation, critical positioning, and sociopolitical action. However, its implementation revealed institutional tensions, especially regarding resistance to addressing gender in the school context. The pre-service teachers’ reflective feedback also evidenced learning related to planning, pedagogical mediation, institutional limits, and the complexity of teaching practice when dealing with socially controversial themes. It is concluded that working with gender as a Socioscientific Issue in Science Education does not imply abandoning scientific content, but rather reorganizing its pedagogical purpose toward the critical understanding of socially relevant problems. This research contributes to the field of Science Education by highlighting the formative potential of articulating STS Education, Socioscientific Issues, and gender in initial teacher education, as well as the concrete challenges of implementing such proposals in school contexts marked by curricular, political, and cultural disputes.
Identificação de regiões com desplacamento de cerâmica em paredes utilizando análise de dados funcionais
(Universidade Federal de São Carlos, 2026-06-29)
Silva, Davi Mazocco Pereira da
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Paz, Rosineide Fernando da
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http://lattes.cnpq.br/0773010734982168
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https://orcid.org/0000-0002-2773-6486
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Zuanetti, Daiane Aparecida
Ceramic wall claddings may conceal serious structural defects that are often detectable only through destructive methods or percussion testing, which are impractical for large façades. Infrared thermography has emerged as a non-invasive alternative, capable of generating thermal images that reveal temperature variations associated with mortar detachment. In this context, this study proposes an automatic classifier that identifies regions with cladding defects based on daily temperature curves extracted from thermographic images segmented into superpixels and converted into RGB values. To achieve this, the color intensities observed throughout each day for each superpixel were smoothed using Fourier basis functions, and the resulting coefficients were employed as explanatory variables in classification models. The performance of the best fitted model proved to be satisfactory.
O ensino da filosofia frente às metodologias ativas
(Universidade Federal de São Carlos, 2026-06-29)
Tripodi, Josiane Cristina
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Maamari, Adriana Mattar
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http://lattes.cnpq.br/5707827597161294
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https://orcid.org/0000-0002-9929-6790
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http://lattes.cnpq.br/0442952214109715
The teaching of Philosophy in high school faces difficulties in connecting students with conceptual content, requiring practices that go beyond simple theoretical exposition and favor problematization, active participation, and the construction of meaning. Technological and cultural changes reinforce the need for conscious teacher mediation, capable of articulating investigation, dialogue, and conceptual rigor. In this context, this research problematizes: how does the use of a didactic sequence based on active methodologies in the teaching of Philosophy in high school contribute to the development of student engagement and the appropriation of philosophical concepts, based on the production of a documentary as an educational product, in a specific school context within the public school system? The general objective is to analyze how a didactic sequence based on active methodologies contributes to student engagement and philosophical learning in high school. This research is characterized as qualitative, descriptive-analytical in nature, developed from the researcher's teaching practice in high school, with the educational product being "Ancestry and Identities: a philosophical narrative". It is concluded that the teaching sequence based on active methodologies, articulated with the production of a documentary as an educational product, demonstrated potential to promote student engagement and favor the appropriation of philosophical concepts in high school.
Qualidade de vida de cuidadores não remunerados de pessoas idosas que vivem com demência: estudo iSupport-Brasil
(Universidade Federal de São Carlos, 2026-06-30)
Silva, Kethelyn Izabella Almeida
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Monteiro, Diana Quirino
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http://lattes.cnpq.br/5135213835907578
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https://orcid.org/0000-0002-3130-4096
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Gratão , Aline Cristina Martins
Introduction: The prevalence of dementia among the older adults has been rising considerably in recent years. Studies indicate that dementia affects not only themselves and society but also unpaid caregivers, who are frequently exposed to stressors that can contribute to a decline in their Quality of Life (QoL). Objective: To analyze factors related to the quality of life of unpaid caregivers of older adults living with dementia. Method: This was a cross-sectional study with an analytical and quantitative approach, using non-probabilistic, purposive sampling and conducted online. The sample consisted of 61 unpaid caregivers of older adults living with dementia (Ascertain Dementia Interview - AD8 ≥2); participants were aged 18 or older, had been providing care for at least six months at the time of recruitment, and had access to an internet-connected smartphone, computer, or tablet. Data collection took place between January 13, 2023, and October 4, 2023, via an electronic questionnaire made available during that period. The following instruments were used for data collection: Initial Assessment Questionnaire (sociodemographic and caregiving profile); Single-Item Burden Scale (S01) and Zarit Burden Interview (ZBI) to assess caregiver burden; Hospital Anxiety and Depression Scale (HADS) to assess depressive and anxiety symptoms; and Quality of Life – Alzheimer's Disease (QoL-AD) to assess quality of life. A significance level of 5% was adopted, and all ethical principles were observed. Results: Duration of caregiving, depressive symptoms, and caregiver burden were the main factors associated with quality of life. Individuals with less than one year of caregiving experience showed a QoL-AD score 18.4% lower than those with one to three years of experience (p=0.027). Participants with possible or probable depression showed a 23.5% reduction in QoL-AD scores compared to those classified as unlikely to have depression (p<0.001). Regarding caregiver burden, those with mild or moderate levels achieved QoL-AD scores 32% to 33% higher than those with severe burden (p=0.027 and p=0.002, respectively). Conclusion: The results of this study highlight the need for strategies aimed at the early screening of depressive symptoms and caregiver burden among those caring for older adults with dementia, as well as the importance of systematic monitoring—especially from the onset of the caregiving experience—through the implementation of targeted interventions in the fields of gerontology and healthcare.
Relações de poder, saber e ética em One Piece: uma análise do personagem Donquixote Doflamingo à luz do pensamento de Michel Foucault
(Universidade Federal de São Carlos, 2026-06-30)
Santos, Gabrielly Cristine Beserra dos
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Carvalho , Pedro Henrique Varoni de
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http://lattes.cnpq.br/0019513394358070
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https://orcid.org/0000-0002-1492-4891
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http://lattes.cnpq.br/7698092481343231
This paper analyzes the discourse of the character Donquixote Doflamingo, from Eiichiro Oda's manga and anime One Piece, based on Michel Foucault's theoretical framework on the relations between knowledge, power, and ethics, in dialogue with the character construction techniques proposed by Syd Field in his screenwriting manual. The starting point is the observation that the work allegorizes power relations of the contemporary world, a phenomenon evidenced by its appropriation in real political movements, such as the youth protests in Nepal in 2025. Doflamingo is chosen as a privileged object of analysis due to his narrative singularity: he is the only character who simultaneously occupies the roles of pirate, king, Celestial Dragon, and Navy-affiliated warlord, making him a living map of the multiple forms power assumes when it is not fixed within a single institution. The research also explores the interdiscursive dimension of the character's name, whose sound evokes Don Quixote de la Mancha, by Miguel de Cervantes, establishing a network of meanings between the nobleman who replaces reality with his own fiction and the villain who imposes his "reality" on Dressrosa through absolute control. Methodologically, the work draws on the Foucauldian concepts of discursive practice, enunciative function, and power relations, articulated with the three-act structure (setup, confrontation, and resolution) described by Field, in order to organize the character's arc between the presentation of his power (episodes 151–513), the revelation of his origin (episodes 623–659), and the confrontation in Dressrosa (episodes 659–736). The results indicate that Doflamingo's discourse articulates a conception of justice and morality as historical constructions determined by those who occupy positions of power, a thesis summarized in his famous line during the Battle of Marineford, according to which justice belongs to the victors. The revelation of his family origin, as a descendant of Celestial Dragons who renounced their title, shifts his characterization from an essentially monstrous antagonist to a product of a corrupt system, expanding the discussion on the relational and diffuse character of power in Foucault. Finally, the contrast between Doflamingo and his brother, Donquixote Rosinante, is used as an analytical resource to highlight the possibilities of resistance within the same power relations that produced both characters. It is concluded that the analysis of Doflamingo's discourse contributes to understanding how globally reaching fictions articulate and legitimize discourses on power, justice, and morality, also shedding light on ethical meanings within the social environment that consumes these cultural products.
Perdas de familiares e a vivência do luto na trajetória da formação graduada de estudantes de terapia ocupacional
(Universidade Federal de São Carlos, 2026-06-30)
Santos, Gabriela Lourenço dos
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Bombarda, Tatiana Barbieri
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https://lattes.cnpq.br/8070700589653226
This study aimed to understand the experiences of loss and grief among undergraduate Occupational Therapy students and how these experiences affect their educational process. This is a descriptive multiple-case study with a qualitative approach. The participants were final-year Occupational Therapy students at the Federal University of São Carlos who had experienced the loss of a family member within the previous five years. Data were collected through individual interviews guided by a semi-structured interview protocol developed based on thanatology literature. The data were summarized on a case-by-case basis and analyzed using Bardin's content analysis. Four female undergraduate students participated in the study. The results showed that the losses were related to the death of elderly family members, and that the grieving process was influenced by the quality of the bond with the deceased and the circumstances surrounding the death. The findings revealed unique and multidimensional repercussions of grief, with social support networks emerging as one of the main resources for coping. The study also identified both the impact of grief on professional education and the influence of academic training on the grieving experience. It is concluded that experiences of loss and grief permeate the educational process in health professions, influencing the development of perspectives on care.
Proposta de sistema de medição externa para agvs seguidores de linha com documentação elaborada para preservação de legado
(Universidade Federal de São Carlos, 2026-06-30)
Sato, Marcelo Itonaga
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Morandin Júnior, Orides
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https://lattes.cnpq.br/4192845106907956
Despite having an MVP of a low cost external measurement system for line follower AGVs, further development of the project wasn’t possible, as it had insufficient documentation which wasn’t up to the laboratory’s standard. As the TEAR laboratory relies on a continuous rotation of undergraduate students every year, the proposed project’s documentation was written from scratch in the form of a Product Requirements Document and a General Architecture Diagram within the SOA architecture, capable of providing a high-level overview of the system and its intended implementation, enabling TEAR members to understand and implement the project. With that documentation, the laboratory’s members were capable of documenting and implementing some of the system’s services while following TEAR’s software development protocol, which resulted in robust services and documentation which will be used by future members of TEAR for its maintenance and updates.
Encontros Nacionais da EJA-EPT (PROEJA) da Rede Federal (2018-2024): desafios e possibilidades para as políticas e a formação de profissionais da educação
(Universidade Federal de São Carlos, 2026-06-30)
Bernardino, Renata Venturim
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Fernandes, Jarina Rodrigues
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http://lattes.cnpq.br/6612611612919706
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https://orcid.org/0000-0001-8028-467X
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http://lattes.cnpq.br/4798073343533159
This research investigates the textual and audiovisual productions of the National EJA-EPT (PROEJA) Meetings of the Federal Network of Professional, Scientific and Technological Education (RFEPCT), held between 2018 and 2024, including recordings, abstracts published in digital Proceedings, and final documents. The objective is to analyze these productions in order to understand the challenges and possibilities related to policies and the training of education professionals for EJA-EPT (PROEJA). The critical theoretical framework adopted is grounded in the perspective of historical-dialectical materialism and in the theoretical debate on the integration of Youth and Adult Education (EJA) and Professional and Technological Education (EPT) within the context of the Federal Network, encompassing the historical development of PROEJA as a public policy, EJA-EPT as a theoretical- epistemological and political field, and the integrated curriculum from the perspective of integral human formation. Methodologically, this is a qualitative bibliographic-documentary study, involving the development of analytical categories grounded in the contributions of Laurence Bardin and in the dialogism matrix proposed by Mikhail Bakhtin. The systematization of data, focusing on two central categories (policies and the training of education professionals), resulted in the construction of an integrative synthesis based on the fundamental categories of the dialectical method, aiming to understand the historicity and processual nature of EJA-EPT (PROEJA) within the Federal Network. The results indicate that these national meetings of the Federal Network constitute important (inter)discursive and dialectical spaces, as they reflect a historical period, intersect the political, scientific, and empirical fields, and foster the production of new knowledge and practices. An intercessory spiral with a moving meaning was presented as an analytical device to highlight the complexity of EJA-EPT (PROEJA), which involves the convergence of multiple determinations in the construction of meanings of this integration and its materialization within an internally heterogeneous Federal Network, configuring it as a dynamic and contested field. It was also concluded that the effective implementation of EJA-EPT (PROEJA), from the perspective of integral and integrated human formation, requires enduring policies for initial teacher education across all teacher education programs, as well as policies to promote and support research and continuing education for education professionals to work with EJA-EPT (PROEJA) within the Federal Network. It also requires the ongoing commitment of researchers, administrators, teachers, and other education professionals, in articulation with civil society organizations.
Economia como fio condutor: dos estudos arqueológicos à governamentalidade liberal em Michel Foucault
(Universidade Federal de São Carlos, 2026-06-30)
Arantes de Souza, Lívia Francisco
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Silveira, Fillipa
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https://lattes.cnpq.br/5054633257502667
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https://orcid.org/0000-0002-9270-3517
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Moutinho, Luiz Damon Santos
This work investigates Michel Foucault's thought, taking as its guiding thread his approach to economic discourses and practices from the archaeological studies of the 1960s to the courses on governmentality of the late 1970s. It addresses (i) the importance of the economic and social conjuncture for what made possible the fall of the human into objectivity (History of Madness); the relationship of economics with (ii) the epistemological imprisonment of the human within its finitude, and the aspects that mark the discontinuity between the analysis of wealth and political economy (The Order of Things); (iii) economic aspects of the relationship between disciplinary mechanics and the emergence of the human sciences (lectures from the first half of the 1970s); (iv) the importance of the economic grasp of the population for the biopolitical consideration of mass human phenomena, and as an organizing axis in terms of the shift away from what serves as the epistemological foundation for the human sciences (lectures from the late 1970s). In light of these aspects, it is argued that relating Foucault's gesture, in the late 1970s, of granting considerable importance to economic liberalism for his diagnosis of the present with his earlier efforts is a way of making explicit the consistency of his work and of avoiding the pitfalls of commentaries that glimpse in his reading of economic liberalism a sign of admiration and political adherence.
Proteômica subtrativa integrativa baseada no genoma e vacinologia reversa identificam potenciais candidatos a vacinas contra Klebsiella oxytoca
(Universidade Federal de São Carlos, 2026-06-30)
Sarcinelli, Maria Carolina Francalassi
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Pranchevicius, Maria. Cristina da Silva
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http://lattes.cnpq.br/4772148921558977
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https://orcid.org/0000-0002-0416-7401
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https://lattes.cnpq.br/6400144868422043
Antimicrobial resistance in Klebsiella oxytoca compromises the therapeutic efficacy of available antibiotics and limits treatment options, highlighting the urgent need for effective preventive strategies. This study describes the in silico development of a multi-epitope vaccine against K. oxytoca through an integrated approach combining reverse vaccinology and subtractive proteomics. Analysis of the pan-genome of 34 strains associated with human hosts identified a core proteome composed of 4.201 conserved proteins. The application of criteria related to essentiality, virulence, antimicrobial resistance, and the absence of homology with human and gut microbiota proteins allowed for the identification of 10 surface proteins with high antigenic potential. These proteins were then subjected to immunogenic epitope prediction, resulting in the identification of 11 MHC class I epitopes, five MHC class II epitopes, and five B-cell epitopes. The selected epitopes were subsequently organized into five multi-epitope vaccine constructs (KOV1–KOV5), containing different adjuvants and the PADRE sequence. All constructs exhibited a favorable antigenic profile, absence of allergenic potential, and adequate solubility. Among them, the KOV4 construct, associated with the L7/L12 ribosomal protein adjuvant, stood out for its superior structural parameters and higher binding affinity for the TLR4-MD2 and TLR1-TLR2 complexes in molecular docking analyses. The stability of these complexes was corroborated by normal mode analysis. Furthermore, immunological simulations indicated the induction of robust humoral and cellular responses, characterized by class switching to IgG, expansion of memory B cells, and cytokine production with a predominantly Th1 profile. Codon adaptation demonstrated potential for efficient expression of the KOV4 vaccine in Escherichia coli, with a CAI index of 0.82 and a GC content of 58.69%. Taken together, these findings highlight KOV4 as a promising vaccine candidate against K. oxytoca, although in vivo and in vitro experimental studies will be necessary to validate its immunogenicity, protective efficacy, and biological safety.
Compostos fenólicos como contaminantes ambientais: revisão sobre fontes, preparo de amostras e métodos cromatográficos
(Universidade Federal de São Carlos, 2026-06-30)
Lopes, Henrique de Andrade
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Urban, Roberta Cerasi
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https://lattes.cnpq.br/7313670290572985
Phenolic compounds represent a relevant class of environmental contaminants due to their wide occurrence, structural diversity and potential impact on ecosystems and human health. Although they may have natural origins, their presence at elevated concentrations in the environment is often associated with anthropogenic activities, such as industrial, agricultural, urban and combustion processes. Due to their physicochemical properties, these compounds can be present in different environmental matrices, such as waters, soils, sediments and the atmosphere, and may also undergo transformations that generate secondary products of environmental interest. In this context, this work presents a literature review on the determination of phenolic compounds in environmental matrices using chromatographic techniques, with a focus on liquid chromatography and gas chromatography. The review addresses the main sources of these compounds, their environmental distribution, their possible impacts and the methodological advances employed in their analysis. Chromatography stands out as an essential tool because it enables the separation and quantification of compounds present in complex samples, especially when associated with sensitive and selective detectors. The studies analyzed indicate that the choice between liquid chromatography and gas chromatography depends on the characteristics of the analytes and the matrix studied. Liquid chromatography is widely applied to more polar and thermally unstable compounds, whereas gas chromatography is more suitable for volatile, semi-volatile or previously derivatized compounds. In both cases, sample preparation is a fundamental step, as it contributes to the removal of interferents, preconcentration of the analytes and the achievement of more reliable results. Overall, there is a growing development of chromatographic methods applied to the monitoring of phenolic compounds in environmental matrices. These advances are important for understanding the occurrence, sources and risks associated with these contaminants, as well as for contributing to strategies for the assessment, control and mitigation of environmental pollution.
Secagem como estratégia para redução de perdas no pós-colheita de frutas e hortaliças: uma revisão
(Universidade Federal de São Carlos, 2026-06-30)
Pinheiro, Caroline Carvalho
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Consoli, Larissa
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https://lattes.cnpq.br/0760277067023906
Fruits and vegetables are highly perishable due to the continuation of metabolic activity after harvest, particularly cellular respiration, combined with their high water content, factors that contribute to significant postharvest losses. In this context, drying stands out as an important preservation strategy by reducing water activity, increasing the commercial stability of foods, and extending their shelf life. This study aimed to conduct a literature review on the application of drying as a preservation technology to reduce postharvest losses in fruits and vegetables. The review addressed the principles of the drying process, heat and mass transfer mechanisms, drying kinetics, and the different drying techniques used in the food industry, including natural drying, tray drying, drum drying, spray drying, infrared drying, and freeze-drying. Scientific articles, books, dissertations, and theses retrieved from national and international databases were used to develop the study. In addition, case studies related to the different drying techniques were analyzed, highlighting the operating conditions, equipment used, and the main results observed for each process. The analysis demonstrated that the choice of drying technique and operating conditions directly influences the final product quality, stability, and preservation of bioactive compounds. Furthermore, these technologies showed great potential for the valorization of agro-industrial residues and the reduction of food waste. Therefore, drying is an important preservation tool, contributing to the reduction of postharvest losses and to the development of products with greater stability and extended shelf life.
Uso unico - impacto permanente: uma revisão bibliográfica sobre os desafios da reciclagem de plásticos médicos
(Universidade Federal de São Carlos, 2026-06-30)
Barreto, Lívia Marques Santos
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Urban, Roberta Cerasi
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https://lattes.cnpq.br/7313670290572985
The increasing use of plastics, particularly intensified during the COVID-19 pandemic, has led to a significant rise in the generation of healthcare waste, highlighting the need for sustainable management practices for these materials. In this context, the recycling of medical plastics faces several challenges, including the diversity of polymers used, which hinders joint recycling due to their different physicochemical properties; the risk of infection associated with contaminated waste, which requires rigorous pre-treatment procedures; pollution resulting from incineration, which releases greenhouse gases and contributes to environmental contamination; the generation of microplastics and nanoplastics, which can persist in ecosystems and be ingested and/or inhaled; the presence of potentially toxic chemical additives that may leach into the environment during waste disposal or processing; and the lack of material identification, which hinders proper segregation and compromises the efficiency of recycling processes. Given this scenario, this study aimed to critically analyze these barriers and discuss possible solutions based on a review of the scientific literature. Finally, sustainable waste management practices were addressed, including appropriate segregation strategies, recycling methods compatible with hospital and industrial settings, and approaches based on circular economy principles, aiming to reduce environmental impacts and promote safer and more efficient management of medical plastic waste.
Entangled states of the light: interference as a symmetry problem
(Universidade Federal de São Carlos, 2026-06-30)
Micheletti Diniz, Ciro
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Jorge Villas Bôas, Celso
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http://lattes.cnpq.br/5700887540085418
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http://lattes.cnpq.br/3102671365275808
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Hassan Youssef Moussa, Miled
Recently, the interference pattern, first observed by Thomas Young in 1804, has been obtained and understood within the framework of quantum optics through light–matter interactions, in which both light and matter are quantized. To this end, multiple fields interact simultaneously with the same material system, such that the superposition of these interactions gives rise to nontrivial detection outcomes. From this perspective, interference is a collective phenomenon. Based on this premise, this thesis develops a unified formalism that shows how symmetry relations are connected to interference effects. As a motivating and technologically relevant case, we analyze reset dynamics in a generic quantum computing and show that collective effects and symmetry relations can dominate the evolution due to shared couplings. Employing tunable features of the device, time-dependent symmetry relations are engineered to dynamically alter the brightness of collective states, enabling the reset of any initial state. In quantum optics, interference effects can be understood as a symmetry problem between the detectable and undetectable components of the field. For coherent and single-photon multimode fields, we derive phase conditions that distinguish bright and dark states, revealing the predominance of the latter. In diffraction gratings, this accounts for the extent of dark regions, where local phases give rise to dark states (zero intensity), while also explaining the high intensity observed in bright fringes. The same reasoning reinterprets cavity pulses as temporal interference between stationary modes, rather than as energy flow, suggesting new insights into the relationship between field intensity and its energy. By extending the analysis to collective thermal states, it is verified that a significant fraction of the energy can remain in dark modes even after interaction with the other systems. Furthermore, a thought experiment was simulated in order to verify how the breaking of symmetry in the interactions can provide access to the energy stored in dark states. Finally, a more fundamental condition for the emergence of collective effects was discussed. Based on shared interactions, Changes in the dynamics of waves of distinct natures, namely mechanical and electromagnetic, were observed when interactions with a common system were considered, as well as in the dynamics of two non-overlapping electromagnetic waves. Nevertheless, the results obtained were consistent with those of the cases previously studied under more restrictive conditions.
Metabarcoding revela variação na composição da comunidade bentônica do substrato inconsolidado no Arquipélago dos Alcatrazes
(Universidade Federal de São Carlos, 2026-06-30)
Ferreira, Amanda do Pinho Cândido
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Capel, Kátia Cristina Cruz
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https://lattes.cnpq.br/3091885302037151
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https://orcid.org/0000-0002-2496-6323
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https://lattes.cnpq.br/1425384949228162
Subtidal marine ecosystems harbor rich biological diversity and play a fundamental role in maintaining global biogeochemical cycles and ocean health. However, monitoring these communities, particularly in unconsolidated substrates, faces the challenges of morphological taxonomic identification. This study used environmental DNA (eDNA) metabarcoding of the Cytochrome oxidase I (COI) gene to investigate the fauna of the subtidal unconsolidated substrate at three sites in the Alcatrazes Archipelago (ESEC, Wolverine, and Geladeira) along a distance gradient from the rocky shore, seeking to understand their spatial structuring. Sediment samples were collected in triplicate, total DNA was extracted, and the COI gene was amplified and sequenced on the Illumina platform. Taxonomic assignment was performed by comparison with the MIDORI2 database. The results revealed significant biological heterogeneity among the sampled sites, with ESEC showing greater absolute richness and Wolverine standing out for its taxonomic uniqueness, with 18% to 20% of exclusive taxa. In contrast, the Geladeira site demonstrated a more simplified community structure, suggesting the influence of local environmental filters on species selection. The analysis of indicator taxa demonstrated the presence of ubiquitous genera (such as Margalefidinium) and others found in only one of the sites, such as Pseudoparamoeba at Wolverine. The disparity between observed richness and the Chao1 estimator indicated that the actual biodiversity in these locations remains underestimated. No significant influence of the distance gradient from the rocky shore was observed on community richness and composition, suggesting a homogeneous distribution of the sediment-associated fauna at the analyzed scale. This study expands knowledge about local biodiversity and provides support for the monitoring of this conservation unit.
Estudo computacional de moléculas com potencial inativante do SARS-CoV-2
(Universidade Federal de São Carlos, 2026-06-30)
Carmo, Paulo Ricardo Leitão do
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Moura, André Farias de
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http://lattes.cnpq.br/0746428641961163
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https://orcid.org/0000-0003-1974-4803
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http://lattes.cnpq.br/9002227824758684
The 3CL-protease (3CLpro) is a crucial therapeutic target against SARS-CoV-2 because it is a non-structural protein linked to viral replication and highly conserved among coronaviruses. This work evaluated in silico, through 1 microsecond molecular dynamics (MD) simulations, the inhibitory activity mecha- nisms and molecular recognition of the 3CL homodimer against two classes of lig-ands: coumarin derivatives (esters of 4-esculetinocarboxylic acid) and copper sulfide nanoparticles functionalized with penicillamine. Coumarin bindings alter the enzy-matic structure in distinct ways; Ethyl 5,6-dihydroxy-2-oxo-1a,7b-dihydrooxyrene[2,3- c]chromene-7b-carboxylate promoted asymmetry at the quaternary interface with loss of dimer compaction, while Ethyl 1,1-dichloro-7,8-dihydroxy-2-oxo-1a,7b-dihy- dro-1H-cyclopropa[c]chromene-7b-carboxylate exhibited a larger thermodynamic layer and conformational stability, despite undergoing partial dissociation followed by spontaneous reassociation. However, a hydrogen bond analysis indicated that the coumarin results fluctuate in the structure without a specific layer. In contrast, the nanoparticles showed a specificity of stereoselective chiral recognition at the dimer- ization interface. The nanoparticle with D-penicillamine severely induced and strengthened attractive interactions between monomers, stabilizing the enzyme. On the other hand, the nanoparticle with L-penicillamine caused allosteric destabilization with weakening of intermolecular forces at the dimer interface. The nanoparticle with L-penicillamine distributed significant isolating bonds, consolidating itself as the chiral vector with the greatest efficiency and dynamic biocompatibility. It is concluded that nanoparticles, especially the levorotatory form, exhibit strong allosteric inhibitory po- tential of 3CLpro, validating the robustness of the methodology for replication in otherpathogenic systems.
Níveis de vitamina D e desempenho cognitivo de pessoas idosas cognitivamente saudáveis e com doença de Alzheimer residentes na comunidade: um estudo transversal
(Universidade Federal de São Carlos, 2026-06-30)
Verzola, Amanda Silva Barison
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Cominetti, Márcia Regina
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http://lattes.cnpq.br/3725318894555272
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https://orcid.org/0000-0001-6385-7392
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http://lattes.cnpq.br/5043103009367904
In recent years, there has been an increase in studies suggesting a relationship between vitamin D levels and brain health. Both the vitamin D receptor and the enzyme that converts 25-hydroxyvitamin D into its active form are expressed in all organs of the body, including brain regions responsible for cognition, mainly the hippocampus, thalamus, hypothalamus, basal ganglia, and cerebellum. Some studies have shown that vitamin D deficiency is associated with a higher risk of cognitive decline and the development of dementias, especially Alzheimer's disease (AD). Other evidence indicates that this association is not yet consistent. Objectives: To investigate the association between serum vitamin D levels and cognitive performance in cognitively healthy older adults and in people living with AD dementia. Methods: This is an analytical observational study with a cross-sectional design. Participants were grouped into two groups: cognitively healthy (n = 147) and with AD (n = 53). The assessment protocol consisted of the following instruments: Sociodemographic questionnaire and health information; Addenbrooke's Cognitive Examination Revised (ACE-R); Mini-Mental State Examination (MMSE); Digit Span Test; Trail Making Test (TMT); Consortium for Establishing a Registry of Alzheimer's Disease (CERAD); Memory Complaints Scale (MCS); Clinical Rating Scale for Dementia (CDR); Geriatric Depression Scale (GDS); Katz Scale; and Lawton and Brody Scale. In addition, blood vitamin D levels were assessed in elderly individuals in the cognitively healthy group. Data were analyzed using the R statistical software. Categorical variables were presented as frequencies and percentages, and continuous variables as mean ± standard deviation and median (interquartile range). For comparisons between groups, the chi-square test, Welch's t-test, and Mann-Whitney test were used, depending on the data distribution. Linear regression models were used to assess the association between vitamin D levels and cognitive outcomes (global score and ACE-R), adjusted for age, sex, education, depressive symptoms, and APOEε4 status. Sensitivity analyses included variables related to sun exposure. Missing data were handled using multiple imputation (MICE), and the Benjamin-Hochberg correction was applied for multiple comparisons. The significance level adopted was 5% (p < 0.05). Results: Individuals with dementia were older (79.0 ± 7.7 years), had lower education (7.1 ± 5.2 years), a higher frequency of the APOE ε4 allele (60.4%), and worse performance on all cognitive tests (p < 0.001), with no significant difference in serum vitamin D levels between the groups. In the adjusted models, vitamin D was not associated with global cognitive performance or ACE-R. Conversely, as expected, older age, the presence of the APOEε4 allele, and depressive symptoms were associated with poorer cognition, whereas higher education was associated with better cognitive performance (p < 0.05). The inclusion of variables related to sun exposure did not modify the results. Conclusion: Serum vitamin D levels were not associated with cognitive performance in older adults, regardless of the diagnostic group. On the other hand, factors such as age, education, presence of the APOEε4 allele, and depressive symptoms showed a significant association with cognition. These findings reinforce the multifactorial nature of cognitive aging and suggest that vitamin D may play a limited role when analyzed in isolation.