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Produção e avaliação de anticorpo policlonal anti-Leishmania para aplicação em diagnóstico
(Universidade Federal de São Carlos, 2020-12-18)
Leishmania is a protozoa genus with several species of intracellular parasites that cause diseases called leishmaniasis, divided into: visceral (VL), the most serious form that affects internal organs and can lead to death, ...
Aplicabilidade clínica da técnica CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats) no tratamento da anemia falciforme: uma revisão integrativa
(Universidade Federal de São Carlos, 2020-12-18)
Introduction and objective: Sickle cell disease is the most common hemoglobinopathy in humans and has a high morbidity and mortality rates. It is caused by a point mutation, an A-T substitution (GAG→GTG) in the first exon ...
Clonagem e expressão de uma xilanase presente no (Meta)transcriptoma do Cupim da espécie Heterotermes tenuis e sua importante aplicação na produção de biocombustíveis
(Universidade Federal de São Carlos, 2021-01-08)
Xylanases are an important group of enzymes responsible for the hydrolysis of the xylan glycosidic chain forming xylose and xylobiosis. Mainly noteworthy is endo-1,4-β-xylanase, a hemicellulase capable of cleaving the β-1,4 ...
Reflexões sobre o papel dos valores nas aplicações biotecnológicas
(Universidade Federal de São Carlos, 2021-01-29)
Biotechnology is the central object of study, it will be classified here as an activity originated in the boundary between science (chemical and biological) and engineering, under the influence of several sets of values, ...
Nanoformulação do [10]-Gingerol em células de câncer de mama triplo negativo
(Universidade Federal de São Carlos, 2020-10-08)
Breast cancer is the neoplasm that most affects women worldwide and can be classified into different types. Among them, triple negative breast cancer (TN) is characterized by not having hormone receptors, nor receptors for ...
Efeito da administração de esteroides anabólico-androgênicos sobre vias metabólicas e alterações morfológicas no tecido muscular esquelético exercitado
(Universidade Federal de São Carlos, 2021-05-05)
The present study, as a descriptive review, aimed to comprehend the effects of the exogenous anabolic-androgenic administration on metabolic pathways, as well as the physiological modulation of the exercised skeletal muscle ...
Estudo sobre a ativação dos receptores canabinoides na função cardíaca de matrinxã, Brycon amazonicus: expressão de proteínas envolvidas no manejo do cálcio
(Universidade Federal de São Carlos, 2021-06-18)
This study aimed to evaluate the effects of activation of CB1 and CB2 receptors on proteins involved in myocardial calcium handling of the tropical fish matrinxã, Brycon amazonicus. Three experimental groups were employed: ...
Mecanismos de regulação gênica relacionados a eficiência alimentar em bovinos da raça Nelore
(Universidade Federal de São Carlos, 2021-06-23)
Brazil is one of the main beef producers and exporters, with herds predominantly composed of Nellore Zebu animals (Bos indicus). In this scenario, genomics can contribute to the identification of potential biomarkers of ...
A autofagia é necessária para a segregação de DNA mitocondrial no Fígado
(Universidade Federal de São Carlos, 2021-06-24)
Mutations in the mitochondrial genome (mtDNA) are ubiquitous in humans and can lead to a broad spectrum of disorders. However, due to the presence of multiple mtDNA molecules in the cell, coexistence of mutant and wild-type ...
Avaliação do potencial antimicrobiano de nanoemulsões à base de compostos de óleos essenciais no controle de espécies de Xanthomonas causadoras do cancro cítrico
(Universidade Federal de São Carlos, 2020-11-27)
Citrus canker is one of the most relevant diseases that affect citrus crops, being responsible for serious economic losses to citrus fruit producers and traders. This disease is caused by Gram-negative bacteria of the genus ...