Vitamin D deficiency predicts 30-day hospital mortality of adults with COVID-19
View/ Open
Date
2022-08-15Author
Neves, Fabio Fernandes
Pott-Junior, Henrique
Santos, Sigrid Sousa
Cominetti, Marcia Regina
Freire, Caio Cesar de Melo
Cunha, Anderson Ferreira da
Jordão Júnior, Alceu Afonso
Metadata
Show full item recordAbstract
Several studies have shown conflicting results for the relationship between vitamin
D deficiency and COVID-19 outcomes. Here, we aimed to evaluate whether plasma 25(OH)D levels
predict mortality in adults admitted with COVID-19, considering potential confounders.
Methods: We conducted a retrospective cohort study that included 115 adults (age 62.1 ± 17.6 years, 65
males) admitted to a Brazilian public hospital for severely symptomatic COVID-19. Subjects were classified into two groups according to their plasma levels of 25(OH)D: sufficiency ( 50 nmol/L) and the
deficiency (<50 nmol/L). The diagnosis of COVID-19 was performed using real-time polymerase chain
reaction (qPCR). In addition, direct competitive chemiluminescence immunoassay assessed serum
25(OH)D levels.
Results: The all-cause 30-day mortality was 13.8% (95% CI: 6.5%e21%) in the group of patients with
sufficient plasma 25(OH)D levels and 32.1% (95% CI: 14.8%e49.4%) among those with deficient plasma
25(OH)D levels. Cox regression showed that plasma 25(OH)D levels remained a significant predictor of
mortality even after adjusting for the covariates sex, age, length of the delay between symptom onset
and hospitalization, and disease severity (HR ¼ 0.98, 95% CI: 0.96e1.00; p ¼ 0.02).
Conclusion: Vitamin D deficiency predicts higher mortality risk in adults with COVID-19.
Collections
The following license files are associated with this item: