Papel histaminérgico cerebelar na consolidação da memória emocional e atividade locomotora em camundongos

Abstract

Experimental evidence suggests that the cerebellum plays a more complex role in learning than simply regulating the motor response. Rather, it is thought to play a significant role in the consolidation of emotional memory in mice. Due to the difficulty of interpreting fear and anxiety behaviors - the standard methodology for the study of the histaminergic system and emotional memory - in mice, we propose a behavioral assessment of mice subjected to the Elevated T-Maze after histamine microinjection of the cerebellar vermis. Young male Swiss albino mice weighing 25 – 35 g were used. In addition, locomotor activity was tested in an open field test. Our data suggest that histamine did not affect memory consolidation during escape or open field behavior at the doses used in this study. However, we observed a significant increase in inhibitory avoidance on the second day in animals receiving a dose of 6.8 nmol/0.5μl, suggesting that histamine facilitates the consolidation of inhibitory avoidance in mice.