Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients

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dc.contributor.authorHeubel, Alessandro Domingues
dc.contributor.authorKabbach, Erika Zavaglia
dc.contributor.authorSchafauser, Nathany Souza
dc.contributor.authorDi Lorenzo, Valéria Amorim Pires
dc.contributor.authorSilva, Audrey Borghi
dc.contributor.authorMendes, Renata Gonçalves
dc.contributor.authorlatteshttp://lattes.cnpq.br/0268406461810882por
dc.contributor.authorlatteshttp://lattes.cnpq.br/4456979306195044por
dc.contributor.authorlatteshttp://lattes.cnpq.br/5075933151971198por
dc.contributor.authorlatteshttp://lattes.cnpq.br/9071791546812165por
dc.contributor.authorlatteshttp://lattes.cnpq.br/4855616925791895por
dc.contributor.authorlatteshttp://lattes.cnpq.br/9634590922242052por
dc.date.accessioned2022-02-08T10:41:04Z
dc.date.available2022-02-08T10:41:04Z
dc.date.issued2021-05-01
dc.descriptionPurpose: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with an elevated risk of cardiovascular events, which can be linked to endothelial dysfunction. In this study, we aimed to investigate whether noninvasive ventilation (NIV) acutely changes endothelial function in hospitalized AECOPD patients. Methods: Twenty-one AECOPD patients were assessed in a hospital ward setting from 24 to 48 h after admission. NIV was applied using a ventilator with bilevel pressure support. Before and after NIV protocol, patients were evaluated regarding (1) endothelium-dependent function, assessed non-invasively using the flow-mediated dilation (FMD) method; (2) arterial blood gas analysis. Other baseline evaluations included clinical and anthropometric data, and laboratory tests. Results: The total group showed a significant improvement in FMD as a result of NIV effect (P = 0.010). While arterial carbon dioxide and oxygen were not altered, oxygen saturation increased after NIV (P = 0.045). The subgroup comparison of responders (FMD ≥ 1%) and non-responders (FMD < 1%) showed significant baseline differences in body mass index (BMI) (P = 0.019) and predicted forced expiratory volume in one second (FEV1) (P = 0.007). In univariate and multivariate analyses, both BMI and FEV1 were determinant for endothelial response to NIV. Conclusion: NIV acutely improves endothelial function in hospitalized AECOPD patients. Overweight and COPD severity may represent important characteristics for the magnitude of peripheral vascular response.eng
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)por
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)por
dc.description.sponsorshipIdCódigo de Financiamento 001 - CAPESpor
dc.description.sponsorshipIdProcesso nº 2015/12763-4, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)por
dc.description.sponsorshipIdProcesso nº 2015/26501–1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)por
dc.identifierhttps://doi.org/10.1016/j.rmed.2021.106389por
dc.identifier.citationHEUBEL, Alessandro Domingues; KABBACH, Erika Zavaglia; SCHAFAUSER, Nathany Souza; DI LORENZO, Valéria Amorim Pires; SILVA, Audrey Borghi; MENDES, Renata Gonçalves. Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients. Repositório Institucional da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/20.500.14289/15555.*
dc.identifier.urihttps://repositorio.ufscar.br/handle/20.500.14289/15555
dc.language.isoengeng
dc.publisherUniversidade Federal de São Carlospor
dc.publisher.addressCâmpus São Carlospor
dc.publisher.departmentDepartamento de Fisioterapia - DFisiopor
dc.publisher.initialsUFSCarpor
dc.publisher.programPrograma de Pós-Graduação em Fisioterapia - PPGFtpor
dc.relation.urihttps://www.resmedjournal.com/article/S0954-6111(21)00095-0/fulltext#relatedArticlespor
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectChronic obstructive pulmonary diseaseeng
dc.subjectNoninvasive ventilationeng
dc.subjectPeripheral vascular functioneng
dc.subject.cnpqCIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONALpor
dc.titleNoninvasive ventilation acutely improves endothelial function in exacerbated COPD patientseng
dc.typeDatasetpor

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