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Envolvimento da neurotransmissão nitrérgica do núcleo leito da estria terminal (NLET) nas respostas cardiovasculares ao estresse em ratos: interação com mecanismos glutamatérgicos e noradrenérgicos locais
(Universidade Federal de São Carlos, 2018-04-02) Barretto-de-Souza, Lucas; Crestani, Carlos Cesar; https://lattes.cnpq.br/1117432571971568; https://lattes.cnpq.br/5795792232582121
The aim of the present study was to assess an interaction between nitrergic neurotransmission within the bed nucleus of the stria terminalis (BNST) with local glutamatergic and noradrenergic neurotransmissions in control of cardiovascular responses evoked by an acute session of restraint stress in rats. For this, all animals were subjected to surgical procedures for implant of bilateral guide cannulas into the BNST and a catheter into the femoral artery. Bilateral microinjection of NMDA into the BNST increased the restraint-evoked tachycardia, but whithout affecting the pressor response and the drop in tail skin temperature. Changes on blood pressure, heart rate and tail skin temperature evoked by restraint stress were recorded. The acute 30 min session of restraint stress was performed five minutes following BNST pharmacological treatments. Bilateral microinjection of NMDA into the BNST enhanced the tachycardia to restraint, but without affecting the pressor response and the drop in tail skin temperature. The effect of NMDA on restraint-evoked tachycardia was completely inhibited in animals pretreated with the selective nNOS inhibitor Nω-Propyl-L-arginine (NPLA) into the BNST. Bilateral microinjection of NOC-9 decreased the heart rate and blood pressure increases evoked by restraint stress. The effect of NOC-9 on HR, but not on blood pressure, was inhibited by BNST pretreatment with WB4101. Besides, microinjection of NPLA in animals pretreated with WB4101 into the BNST decreased the HR and blood pressure increases to restraint. Taken together, these results indicate that the inhibitory control of cardiovascular responses to stress by BNST nitrergic neurotransmission is mediated by a facilitation of local noradrenergic neurotransmission. Also, present data provide evidence of an involvement of local nNOS in facilitatory control of the NMDA receptor within the BNST.
Driv-uml: visualização de não-conformidades arquiteturais em UML no contexto da modernização dirigida a arquitetura
(Universidade Federal de São Carlos, 2018-04-02) Gasparini, Bruno César; Camargo, Valter Vieira de; https://lattes.cnpq.br/6809743774407662; https://lattes.cnpq.br/5127360855999753
As a means of dealing with legacy systems, reengineering has become a trend in software engineering. In this context Architecture-Driven Modernization has emerged as a standard between the different reengineering techniques. Computer systems are affected by a considerable amount of modifications and improvements, however if not considered as a main concern, the software architecture may deteriorate over time and deviate from the intended architecture. In this scenario, this project aims to assist the architectural conformance checking process, displaying graphically by means of UML diagrams, the architectural nonconformities detected by the Architecture Conformance Checking (ACC) tool ArchKDM. In order to accomplish this task, the approach receives a set of violations identified by this tool and, from these, produce UML class and package diagrams. On this approach, the architectural drifts are shown by means of UML relationships between code elements (layers, components, classes, etc.). The code elements are illustrated as UML elements. It is important to mention that UML role in this approach context is to display only architectural drifts. The approach aims two different abstraction perspectives, a fine-grained, based on a class diagrams and another coarse-grained, based on package diagrams. The CCA tool that supports the approach is the ArchKDM. ArchKDM output file is an instance of KDM metamodel containing architectural nonconformities. Thus, in order to support the approach, two discoverers for Modisco plugin will be developed. These discoveries are in charge of recovering and building diagrams from the metamodel instance. This project is evaluated by an empiric study whose purpose is to expose the tool to a diversified set of, already in production, softwares.
Extensão de uma álgebra ER para execução de consultas em bancos de dados NoSQL orientados a documentos
(Universidade Federal de São Carlos, 2018-04-02) Noguera, Viviana Elizabeth Romero; Lucrédio, Daniel; https://lattes.cnpq.br/9090396559596221; https://lattes.cnpq.br/2452374458203874
Non-relational databases, also called as NoSQL (``Not Only SQL''), have emerged from the need for new mechanisms for storing, retrieving and processing for large amounts of data produced mainly from the coming of Web 2.0 applications. There are different models of non-relational data, each with its own characteristics and applicability. There are also hundreds of non-relational database management systems, each with a different query language,and its own API. Due to the lack of a standard for data manipulation languages (DML) in this type of database, it is a challenge for the Software Engineer to deal with the learning and development of queries.In addition, by prioritizing performance, non-relational databases often adopt denormalized schemas, generating a large diversity in stored data structures, which also makes it difficult to develop and reuse queries. Faced with these two challenges, this work aimed to define a generic approach to queries, independent of the database type and also independent of the schema in which the data is stored. For this, extended an existent algebra, based on Entities and Relationships for data manipulation, with an operational semantics driven by models (Model-Driven Engineering - MDE). More specifically, metamodels have been developed so that the Software Engineer can: (i) model the persistent entities (Entity-Relationship); (ii) model queries about the entities and relationships according to the algebra being used; and (iii) model the mapping between the entities and the types of documents stored. Based on these specifications, an algorithm was implemented that automatically generates JavaScript queries to be executed in the MongoDB database, according to the mapping model. If the database schema needs to be modified throughout the lifecycle, only the mapping model (model ``iii'') needs to be modified. The conceptual model and the queries (``i'' and ``ii'' models) remain completely independent of the storage schema and can be developed and reused more easily. Two evaluations were carried out, using an example of an academic system and a real system, trying to exhaustively test the different possibilities of mapping between entities and documents. The results obtained with these systems show that it is possible that the generated queries always return the same results, independent of the mapping, thus reaching the objective of this work.