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Pelas f(r)estas da cidade: práticas espaciais urbanas no contexto da Atenção Psicossocial de Fortaleza
(Universidade Federal de São Carlos, 2025-05-23) Dantas, João Gabriel Trajano; Ferigato, Sabrina Helena; https://lattes.cnpq.br/3248396158325409; https://orcid.org/0000-0001-7567-7225; Branco; https://lattes.cnpq.br/1057076984543951; https://orcid.org/0000-0002-8273-9137
The consolidation of Psychosocial Care in Brazil highlights the relationship with territory and community as a guiding principle for the operation of services and the production of mental health care for the population. This aspect encourages the development of practices that transcend institutional walls, gaining color, rhythm, meaning, and dialogue within various urban spaces. It is within this context that the central question of this thesis emerges: how can practices mediated by artistic and cultural experiences, carried out in urban public spaces, contribute to the production of cracks (f(r)estas) that celebrate the principles of citizenship, inclusion, sociocultural participation, belonging, diversity, and mental health care? To engage with this question, we adopted a qualitative and exploratory research-intervention methodology, grounded in a cartographic perspective. The objective is to analyze the production of mental health and the occupation of urban public spaces through the cartography of experiences lived in the city of Fortaleza, Ceará, Brazil. The investigation was conducted mainly from the perspective of professionals and service users regarding the daily work within Psychosocial Care, as well as through the procedural follow-up of two experiences: the traditional carnival group ‘Doido é Tu’ (BDT) and the II Mad Pride Parade, an event related to the Anti-Asylum Campaing Day. The results are presented through three pathways: the historical-political dimension; the molecular or everyday dimension of work in Psychosocial Care; and the sociocultural dimension of urban practices and their interface with care. The investigative journey contributes to the field by proposing the notion of f(r)estas, through an articulation between mental health, art, and culture in the city. It concludes that urban spatial practices can function both as analyzers of management and care models in mental health and as conditions and effects of clinical practices committed to social emancipation. The production of f(r)estas arises from the collective construction of spaces of joy, celebration, and festivity, reclaiming urban daily life for the diversity of ways of living, citizenship, cultural practices, and belonging, as well as for the exercise and defense of the right to care in freedom.
Análise exploratória de proteômica em tecido ruminal de bovinos Nelore (Bos indicus): impacto da alimentação e relação com a emissão de metano
(Universidade Federal de São Carlos, 2025-05-23) Santos, Mykaelli Andrade; Nogueira, Ana Rita de Araújo; https://lattes.cnpq.br/7034773971317045; https://orcid.org/0000-0003-3648-2956; https://lattes.cnpq.br/0491485411953509; https://orcid.org/0009-0007-2448-247X
Through proteomic approaches, this thesis explores the molecular adaptive mechanisms of the ruminal tissue in Nelore cattle (Bos indicus) in response to different nutritional interventions and variations in residual methane emissions. In the first chapter, the proteomic profiles of steers fed a conventional diet rich in corn grain were compared to those of steers receiving a diet formulated with agro-industrial by-products. The results demonstrated that the protein composition of the rumen is significantly modulated by the diet, reflecting specific cellular adaptations. The findings identified seven differentially abundant proteins related to structure, extracellular matrix remodeling, cytoskeletal organization, cellular regulation, and iron homeostasis. Notably, the reduced expression of FTH1 in the by-product diet suggests lower oxidative stress and inflammation. At the same time, the upregulation of six proteins indicates structural and metabolic adaptations within the ruminal tissue. In the second chapter, the thesis investigates the molecular mechanisms regulating methane emissions, a potent greenhouse gas, through a comparative analysis of the ruminal proteomic profile in cattle with differing residual methane emissions (RME) levels. Utilizing a shotgun proteomics approach, 37 differentially abundant proteins were identified between the high and low-emission groups. The data revealed that, in the low-emission group, proteins associated with protein degradation and energy metabolism were more abundant, suggesting more efficient fermentation and consequently reduced methane production. Conversely, the high-emission group exhibited upregulation of proteins involved in protein synthesis, lipid biosynthesis, and immune responses, which may indicate lower metabolic efficiency. Overall, the findings of this thesis provide new insights into the molecular mechanisms governing both the adaptive responses of ruminal tissue to varying nutritional profiles and methane production. These results may contribute to developing nutritional strategies to enhance feed efficiency and reduce greenhouse gas emissions in beef cattle production.