Influência da interação medicamentosa no limiar de dor à pressão em indivíduos com osteoartrite de joelho

Abstract

Objectives: To evaluate the influence of drug interaction on the pressure pain threshold in a patient with knee osteoarthritis (KOA). Secondarily, we sought to assess the body composition of subjects with KOA and its relationship with drug interaction. Two studies were carried out: I: Association between drug interaction and pressure pain threshold in individuals with knee osteoarthritis: A cross-sectional study; II: Is the presence of drug interaction associated with a higher prevalence of fat mass in body composition in individuals with knee osteoarthritis? Methods: Study I describes in detail the methodology of Study II, where 80 participants with KOA aged over 40 years presented the sample. Pain threshold assessment was performed using a pressure algometer, at four points close to the knee. The Drugs.com database was used to check for possible headaches between medications used for knee pain and other medications used by participants with KOA. In addition, the Western Ontario and MacMaster Universities Osteoarthritis Index Questionnaire (WOMAC) and Numerical Pain Scale (END) were applied as complementary pain estimates. The secondary ones included data on body composition, through the Dual-Energy X-Ray Absorptiometry (DXA) equipment. In addition, the Pain Catastrophizing Scale and the Tampa Scale for Kinesiophobia were applied as complementary pain estimates. Results: The results indicate that the presence of drug interaction is associated with a lower pressure pain threshold, being linked to advanced age and higher levels of pain reported by the END. In addition, it was demonstrated that there is an association between the presence of associated diseases and high levels of fat, associated with the presence of drug interactions, without association with muscle and bone mass. Conclusion: The study tested that drug interaction is associated with a decrease in pressure pain threshold and a greater presence of fat mass in individuals with KOA.