Influência da lesão condral na concentração de glicosaminoglicanas sulfatadas no líquido sinovial.
Abstract
Objective. To evaluate the influence of sulfated glycosaminoglycan (GAG) concentration in synovial
fluid from individuals with chondral injuries, either isolated or associated with anterior cruciate ligament
injury or meniscal injury, and check for an association between time since injury and the degree of
chondral injury. Material and Method. Twenty-nine adult subjects (25 men and 4 women, mean age
38.3 ± 10.9 years) were selected. Samples obtained from all subjects were quantified to determine the
GAG concentration using dimethylmethylene blue dye. The degree of chondral damage was
macroscopically evaluated by arthroscopy and rated according to the International Cartilage Repair
Society (ICRS) classification. Results. Significant differences were found concerning the GAG
concentration in the control group compared with the other groups (p<0.05). No significant differences
were found between the studied groups concerning time since injury and degree of chondral damage
according to the ICRS. A strong correlation was found between GAG concentration and time since injury
in the chondral injury group (r= -1). Conclusion. Damage to articular structures seems to be the
determining factor in the change of synovial fluid GAG concentration, being higher in isolated chondral
injury. When associated with anterior cruciate ligament rupture and/or meniscal injury, it will promote a
tendency to fall, and is not related to sex, age, time since injury and degree of chondral injury in all
groups studied.