Marcadores de potência circulatória e ventilatória em pacientes com diabetes mellitus tipo 2: influência do controle glicêmico

Abstract

Cardiorespiratory function has been shown to be impaired in individuals with type 2 diabetes mellitus (T2DM). Circulatory power (CP) and ventilatory power (VP) obtained by the cardiopulmonary exercise test (CPET) are indices that assess the integrity cardiopulmonary, however, the influence of glycemic control on these indicators still deserves be investigated. OBJECTIVE: To investigate the influence of glycemic control on CP indices and VP in T2DM. METHODS: Individuals with T2DM of both genders aged between 40 and 64 years who, after carrying out a laboratory blood test, were allocated into two groups of according to glycated hemoglobin (HbA1c) in: good glycemic control (GGC, n=11, HbA1c ≤ 7%) and poor glycemic control (PGC, n=26, HbA1c > 7%). All participants underwent CPET on a treadmill, applying the Bruce protocol with increment in incline and speed every 3 minutes. For ergospirometric analysis, an Oxycon Mobile® gas analyzer was used and peak (consumption oxygen) VO2 was considered the highest value observed in the last 30 seconds of the test. CP values ​​were obtained by the product of peak VO2 by systolic blood pressure (SBP) and VP by SBP division by ventilatory efficiency (VE/VCO2slope). The significance level was set at p<0.05. RESULTS: The groups were similar in terms of baseline characteristics, except for the expected fasting blood glucose and HbA1c. As for the CP and VP indices, the groups with different glycemic profiles were also similar, CP: GGC:4756.05±1061.67 and PGC: 4434.15±1247.83 mmHg.ml.kg-1min-1 p=0.460 and VP: GGC: 5.85±1.08 and PGC: 5.86±1.31 mmHg.ml.kg-1min-1 p=0.978. CONCLUSION: Regardless of glycemic control, the cardiopulmonary integrity indices, CP and VP, were similar in individuals with T2DM. The predictive capacity of these variables on health outcomes deserves further investigation. in T2DM.