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Complexos de Pd(II) e Pt(II) contendo tiossemicarbazonas derivadas do tiofeno: síntese, caracterização, investigação da citotoxicidade e modo de ação
(Universidade Federal de São Carlos, 2022-03-16)
Oliveira, Gabriela Porto de
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Rocha, Fillipe Vieira
;
https://lattes.cnpq.br/5841127259122766
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https://lattes.cnpq.br/8902113201652123
In this work, ten ligands and four palladium and two platinum complexes containing thiosemicarbazones derived from thiophene were synthesized in order to evaluate their cytotoxic profile against tumor cells. The compounds were characterized by molar conductivity, Nuclear Magnetic Resonance (31P{1H}, 1H and 13C{1H} NMR, COSY, HMBC, and HSQC), Infrared (IR) Absorption Spectroscopy, Ultraviolet-Visible Absorption Spectroscopy, Elemental analysis, ESI/MS Mass Spectrometry, and Single Crystal X-ray Diffraction (XRD). From the set of techniques, it was possible to verify that the ligands coordinated in an anionic bidentate form, with the exception of the PtT complex, which coordinated in a neutral form, via nitrogen and sulfur atoms of the thiosemicarbazone and the other sites are occupied by a chloride ligand and a triphenylphosphine. The compounds were subjected to stability tests in DMSO, which suggested the permanence of the chloride ligand in the coordination sphere. Afterwards its cytotoxicity was evaluated by the MTT method against the tumor cell lines DU-145 (prostate), A549 (lung), MDA-MB-231 (breast), A2780 Cis (ovary) and non-tumor cell line MRC5 (lung). The ligands were inactive in all cell lines tested, while the complexes were more promising concerning the A549 and A2780 Cis tumor lines. The most cytotoxic compound PdT showed cytostatic behavior against the A549 tumor lineage, while the PdCH3 compound exhibited antimetastatic and cytotoxic behavior against the A2780 Cis cell line. To explore a possible biological target, DNA interaction assays were performed. These data indicate that the complexes interacted with DNA only at high concentrations (100 uM). Moreover, they suggest that the interaction pathway is electrostatic and/or via groove binding with DNA. Additionally, they could not inhibit the action of topoisomerase IIα and IIβ enzymes. However, the platinum complexes inhibited topoisomerase Iβ at all concentrations evaluated (0.1-100 μM). The most promising compound, PdCH3, provided the accumulation of cells in the sub-G1 phase of the cell cycle, which may indicate induction of apoptosis. Furthermore, this complex inhibited wound closure in Wound Healing assays and significantly altered cell morphology. Such data represent an effective ability to affect the cell viability of cancer cells. These results indicate that the synthesized palladium compounds have an encouraging biological activity.
Avaliação dos efeitos da pandemia de Covid-19 sobre a evasão estudantil nos cursos superiores de tecnologia do IFSP São Carlos
(Universidade Federal de São Carlos, 2022-03-16)
Mendes, Ricardo Pertile Frota Teixeira
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Carvalho, Joelson Gonçalves de
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https://lattes.cnpq.br/0141039743607067
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https://lattes.cnpq.br/1540492076655091
This work is about education, particularly, the phenomenon of student dropout, a common and recurrent problem in educational institutions in general. Studies indicate that the students who start, but do not finish their courses are related to social, academic and economic loss. In the public sector, they correspond to public resources invested without the expected return to society. The research target of the work is the Federal Institute of Education, Science and Technology of São Paulo, São Carlos campus, covering the period that marks the beginning of the Covid-19 pandemic in Brazil, from mid-March 2020 until December de 2021. The main objective is to understand the strategies to combat student dropout in higher technology courses on campus occurred during the Covid-19 pandemic. In order to evaluate the phenomenon from a chronological perspective, it was decided to break down the main objective into three specific objectives: 1. To verify the institutional response to the pandemic. 2. Evaluate the phenomena of dropout and student retention and the institutional response during the pandemic and 3. Compare dropout indicators before and after the pandemic. The methodological structure includes a bibliographic review, document analysis and participant observation, conducted through semi-structured interviews with representative agents, employees of the institution who work directly and behind the scenes of teaching, including administrative technicians who provide support as facilitators and teachers, the leading characters of the emergency remote teaching system. The evaluation of the Covid-19 institutional contingency plan by the interviewees was positive, contrasting with the common perception of the intensification of dropout phenomenon in the period. Despite the gap between the onset of the pandemic and institutional actions to combat it, good indicators were found for evasion, suggesting that the positive results obtained may be artificial, being biased by the institutional policy.
Organização de informações digitais pessoais: um estudo sobre as práticas e percepções de organização de discentes universitários
(Universidade Federal de São Carlos, 2022-03-16)
Bertazzi, Pedro Eduardo Rocha
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Furnival, Ariadne Chloe Mary
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https://lattes.cnpq.br/2264201747953240
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https://lattes.cnpq.br/1291482506649810
O presente trabalho visou mapear as práticas e as percepções que os discentes de uma universidade federal têm sobre a maneira que organizam, tratam, arquivam e acessam seus documentos digitais pessoais, além de oferecer um arcabouço informacional sobre o comportamento deles para subsidiar futuras atividades de letramento informacional e desenvolvimento de novas tecnologias. Foi usado como procedimento metodológico a pesquisa de levantamento (survey) e a coleta de dados se deu através da aplicação de um questionário online. Os principais resultados encontrados foram que os discentes possuem um sistema próprio de organização e confiam nele. Junto a isso, observamos práticas que podem ser postas em debates e trabalhadas como o salvamento excessivo de arquivos, relutância de apagar arquivos não importantes e a caracterização do sistema em nuvem e HDs externos como arquivos intermitentes. Sendo assim, pode-se concluir que há necessidade de atividades de letramento informacional para estimular e aprimorar as competências em informação nos processos de arquivamento e organização de arquivos digitais dos discentes universitários, o que contribuirá para as tomadas de decisões futuras no mundo acadêmico.
Metadados do subprojeto HU UFSCar do projeto "Inovação e transformação da atividade de prevenção de riscos profissionais – ITAPAR"
(Universidade Federal de São Carlos, 2022-03-16)
Mininel, Vivian Aline
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Moura, Daniel Braatz Antunes de Almeida
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https://lattes.cnpq.br/4557060516800427
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https://lattes.cnpq.br/5287608431146025
Filmes comestíveis de guacamole: relações entre as proporções dos componentes e as propriedades
(Universidade Federal de São Carlos, 2022-03-16)
Matos, Matheus Carvalho de
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Azeredo, Henriette Monteiro Cordeiro de
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https://lattes.cnpq.br/8516223928904348
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https://lattes.cnpq.br/8522602961816619
The food industry has tried to develop products that meet the requirements of consumers, especially in terms of sensory and health aspects as well as convenience. In times when food delivery has been very frequent, some multicomponent foods may suffer texture changes from water migration between components with a high water activity difference. The present study aimed to develop and characterize edible films from bacterial cellulose and guacamole, to be consumed as a snack or applied as a water barrier layer in multicomponent foods such as tacos, pizzas, and wraps, reducing the water migration and avoiding texture changes. Ten films were produced with different proportions of biopolymeric matrix (bacterial celulose – BC - and carboxymethyl cellulose - CMC), plasticizer (glycerol) and flavor component (guacamole), according to a simplex-centroid design. The results indicated the potential applicability of the films, as well as the influence of the component proportions on the tensile properties, the water vapor permeability (WVP) and the surface hydrophobicity. Films with higher proportions of cellulosic matrix presented lower WVP values, being more promising for the prospected application. An application test was carried out in which the film was tested as a barrier layer between nachos and tomato sauce, and the texture of the nachos was tested after 50 min. The film reduced the texture loss by the nachos, indicating that the water migration was decreased.
Política industrial em países dependentes: limites estruturais do novo desenvolvimentismo
(Universidade Federal de São Carlos, 2022-03-17)
Barbosa, Tayla Nayara
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Carvalho, Joelson Gonçalves de
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https://lattes.cnpq.br/0141039743607067
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https://lattes.cnpq.br/1006450649563809
The objective of the research was to analyze and compare the structural economic limits of the new South American developmentalism, taking the cases of Brazil and Argentina as examples. The focus of the analysis was the Lula administration (2003-2010) in Brazil and the Néstor Kirchner (2003-2007) and Cristina Fernández de Kirchner (2007-2011) governments in Argentina. The analysis of these limits was based on the dependency theory of Ruy Mauro Marini (1973), according to which the economies of Latin American countries belong to a historical process of power relations, since they are dependent on transfers of value from the central economies. Therefore, in general, the new developmentalism is seen as an economic development strategy that theoretically proposes to guarantee the binomial: economic growth and income distribution. Thus, what we intend to analyze is whether the economic orientations based on the new developmentalism and implemented by these governments diverged or converged with neoliberalism. The hypothesis investigated is that the new developmentalism failed to constitute itself as an alternative long-term development model, since it did not configure itself as a counter-hegemonic project to neoliberalism.
Contribuição ao estudo de pilares pré-moldados de concreto em etapa transitória
(Universidade Federal de São Carlos, 2022-03-17)
Otrente, João Francisco
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Ferreira, Marcelo de Araújo
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https://lattes.cnpq.br/4199122391532470
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https://lattes.cnpq.br/3182929421075739
During its production, the precast structures go through different stages called the transitory stage and, consequently, through different static schemes and requests. The precast columns during this stage have a static beam scheme which can cause particular design situations in which the transitory stage is critical for the design. In addition, many designers do not consider the loss of stiffness due to eventual cracking of the element at this stage. The objective of this work is to evaluate how the application of prestressing with pre-tension helps in the performance of precast concrete columns in particular design situations in which the formation of cracks in the phases of the transitory stage can occur. To achieve this, a case study was carried out on a precast concrete column with a critical transitory stage. The column was analyzed in reinforcement concrete with different static schemes and later in prestressed concrete containing two arrangements of active reinforcement. The analysis of the element in question was performed using the following parameters: tension in the reinforcement, cracking moment, amount of reinforcement and secant flexion stiffness via analytical methods. In addition, a parametric analysis was carried out during the demolding phase and lifting in assembly, whose parameters obtained from the variation of the position of the lifting loops were: bending moments, tension in the reinforcement and stiffness reduction coefficient for the most requested sections. Based on the analysis of the results, it is concluded that when using three lifting loops, the column presented a stiffness of up to 0.84.EI during demolding. With the introduction of prestressing, the column with two lifting loops resulted in a stiffness of up to 0.90.EI at the end of transitory stage. Still, it was observed, via parametric analysis, that the column only presented a stiffness bigger than 0.50.EI when the stress level in the passive reinforcement was less than 0.30.fyk. Finally, it is understood that the loss of stiffness during the transitory stage must be accounted for.
Soluções positivas para equações elípticas com operadores fracionários
(Universidade Federal de São Carlos, 2022-03-18)
Villena, Diana Yovani Rodriguez
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Paiva, Francisco Odair Vieira de
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https://lattes.cnpq.br/2889322093175193
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https://lattes.cnpq.br/0177562178388522
In this work, we present results of existence, non-existence and multiplicity of positive solutions to elliptic problems involving the fractional p-Laplacian operator and the fractional Laplacian in the critical case, through variational methods, sub-super solutions and Mountain Pass Theorem.
Moradia e idoso: um estudo sobre o lugar de envelhecer
(Universidade Federal de São Carlos, 2022-03-18)
Grezele, Gabriely
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Silva, Nayara Mendes
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https://lattes.cnpq.br/1791265073266957
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Monteiro, Luzia Cristina Antoniossi
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https://lattes.cnpq.br/2890278808923978
The place of residence directly reflects on active and healthy old age. It is known that the aging process is accompanied by a series of biopsychosocial issues influenced by several factors. Adequate housing can be a facilitator in the process. However, the elderly population increasingly depends on State initiatives to obtain access to adequate housing, and therefore, dignified conditions in old age, reflecting on functional capacity. In this scenario, specific public policies that do not take into account aspects related to health and well being can impact daily activities of daily living and relationships with the place. In this sense, there is a need for studies that investigate housing characteristics and the profile of the elderly in each location, in order to deepen the knowledge regarding the socio-spatial insertion of the resident. It is understood that care policies for the elderly can promote active and healthy aging, regardless of the level of socioeconomic development, enabling the maintenance of functional capacity in a safe environment, encouraging participation in the community. Therefore, the objective of this study was to analyze the housing conditions and the functional capacity of elderly residents of the CECAP neighborhood in Araraquara-SP. It is a transversal, exploratory and descriptive research, based on the quantitative-qualitative method of investigation. The research participants were elderly people registered in the public health facilities that served the neighborhood. Interviews were conducted with semi-structured questions, and the Brazilian Oars Multidimensional Functional Assessment Questionnaire (BOMFAQ) was used to assess functional capacity. The results indicated that the interviewees do not have severe commitment to the performance of daily activities, but they have greater difficulties in the IADL, which are related to health conditions and not directly with the neighborhood. Regarding the participants' perception of housing, it was noted that the feeling of well-being, possession, living conditions and the understanding that there is an offer of product and service structures within the neighborhood, are important aspects that reflect on the quality of housing. of what is lived and the understanding that their housing meets their needs, reflecting on the feeling of belonging, integration and conditions to enjoy the space independently, actively and with dignity in old age.
Ensino de física para surdos: um estudo das teses e dissertações (2007 – 2020)
(Universidade Federal de São Carlos, 2022-03-18)
Stavel, Michael de Oliveira
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Cruz, Tersio Guilherme de Souza
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https://lattes.cnpq.br/0705292304279277
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Silva, Fernanda Keila Marinho da
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https://lattes.cnpq.br/6390725197649567
This final paper approaches the state of knowledge about physics teaching for deaf in the two first decades of the 21th century. For this purpose, a survey of the works present in the CAPES theses and dissertations catalog was carried out and, subsequently, an analysis from titles and abstracts of these thesis and dissertations were made. The study questions are: how many and which are there on this subject? Are these researches articulated? Are there conclusions about methodologies to teach physics with people with hearing disability? What have been the concerns of researchers in the teaching of physics for the deaf? These questions provided theses objectives: to present an overview of theses and dissertations about physics teaching for deaf and discuss methodological and pedagogical aspects found in these works. The results indicated a trend of increasing academic production over the years. Furthermore, we found 27 works distributed in the five regions of Brazil, which can be classified into three thematic approaches: 1) related to didactic resources; 2) related to the understanding of the learning process and, 3) related to communication in LIBRAS of scientific terms. It is necessary to mention that these three thematic focus were also described by other authors, in similar studies, which supported and contributed to this final paper.
A leitura e escrita no contexto da educação infantil
(Universidade Federal de São Carlos, 2022-03-18)
Palauro, Natália Gonçalves
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Monteiro, Maria Iolanda
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https://lattes.cnpq.br/4189205834370563
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https://lattes.cnpq.br/5899168538421559
This bibliographic work aims to survey the relationship between teaching and pedagogical practice and the formation of reading and writing habits from Early Childhood Education, analyzing the work carried out before and after the approval of the BNCC (BRASIL, 2017). The analyzed researches were from the universities around the Federal University of São Carlos, São Carlos – São Paulo. The research base was from the critical historical pedagogy
Formação em cuidados paliativos: apontamentos sobre o processo de ensino na Universidade Federal de São Carlos
(Universidade Federal de São Carlos, 2022-03-18)
Gomes, Maria Caroline Volpin
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Bombarda, Tatiana Barbieri
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https://lattes.cnpq.br/8070700589653226
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https://lattes.cnpq.br/3300621760349154
The National Academy of Palliative Care argues that the teaching of palliative care must occur systematically in undergraduate and graduate courses, as a way to guarantee qualified assistance to who need. Yet, in Brazil, matrices of essential skills are still being developed. This study sought to understand the teaching scenario on palliative care in health courses at the Federal University of São Carlos. This is a descriptive study, with a mixed approach, developed in two stages: documental study with analysis of pedagogical projects, curriculum matrices and teaching plans; and interviews with teachers who provide contents about palliative care within the scope of the teaching and extension. The information from the documentary data was descriptively organized in Excel spreadsheets and an analysis was based on the fundamentals and principles of palliative care. Thematic analysis was carried out for the contents from the interviews. As a result, it was observed the absence of specific disciplines on palliative care and the scarcity of content on the subject inserted in the disciplines that integrate the curriculum matrix. The difficulties in teaching palliative care from the teachers' point of view are due to the lack of understanding on the subject; the difficulty in providing changes in the curricular structure and the reduced number of qualified teachers in the discipline. It was found that the teaching scenario at this federal university presents significant fragility in training in palliative care, a situation resulting from multifactorial aspects from the perspective of professors. The demand for professional training involving skills that guarantee the recognition of the indication for palliative care in a qualified way is notorious, avoiding late or inadequate referrals in health care, a factor that requires efforts and reflections on strategies that minimize the training gaps identified. In this aspect, it is believed that the development of matrixes of essential competences for the performance of palliative care can favor improvements in the training processes, as well as that initiatives of interdepartmental actions can contribute to the reduction of weaknesses identified in this institution.
Síntese de compostos N-heterocíclicos via fotocatálise
(Universidade Federal de São Carlos, 2022-03-18)
Souza, Wanderson Costa de
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Paixão, Márcio Weber
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https://lattes.cnpq.br/3773908504964104
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https://lattes.cnpq.br/2206081928328489
Heterocycles belong to a privileged class of organic compounds that play a prominent role in chemistry and biology. There is an extensive literature about methodologies for the synthesis of these substances, showing their importance. In the last decade, photocatalysis has undergone a substantial expansion driven by the search for new ways to achieve molecule activation and the growing interest in the development of more sustainable methodologies. In view of this scenario, our group has sought to contribute to the progress of photocatalyzed methodologies, applying photocatalysis to synthesize N-heterocyclic compounds. In this study, three photocatalytic methodologies were developed, one employing photoredox catalysis and the others employing photocatalysis by energy transfer. The first one is described as a cascade cyclization reaction initiated by alkyl radicals generated via photocatalyzed deamination by visible light. Under mild reaction conditions, the developed method provides a series of benzazepinones with a wide substrate scope, good functional group tolerance and good yields. In the second methodology, the synthesis of cyclobutanequinolinones was achieved through [2+2] cycloaddition reactions by energy transfer. The method has also a wide substrate scope, tolerates structural variations well and produces a large variety of cyclobutane derivatives with yields ranging from 27-99%, and with excellent regio- and diastereoselectivity. The third methodology was developed using 1,3-enynes in photocatalyzed reactions. It is a highly sustainable methodology which employs a metal-free catalyst (1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene) (4CzIPN), blue LED as activation source and a dimethylcarbonate solvent. (DMC). By this method, a series of 1,3-diene quinolinone derivatives were obtained in excellent yields.
Simulação numérica do processo de secagem de concretos refratários em aplicações tecnológicas
(Universidade Federal de São Carlos, 2022-03-21)
Cunha, Túlio Mumic
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Luz, Ana Paula da
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https://lattes.cnpq.br/3470395641242374
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Pandolfelli, Victor Carlos
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https://lattes.cnpq.br/7369376873984839
Refractory ceramics are used in high temperatures due to their unique properties that enable a high thermal and chemical stability, mechanical strength, thermal properties and others. These materials are split into two main groups: shaped and monolithic. The latter acquires its shape during application and is commonly obtained as a powder, to which a liquid, commonly water, is added for mixing and for reacting with the binding agents to guarantee suitable green strength. Following, it is subjected to careful heating schedule to withdraw this water, because rapid generation of steam can lead to the failure of the lining. The drying process is often approached empirically in the industry, and this work aims to introduce a computational methodology for comparison and optimization of such heating profiles. Initially, a finite element method modeling was developed, with the help of a library, in Python, which was the basis for a number of simulations that were divided into three stages: profiles with constant heating rate, others with a plateau and also complex curves. The analyzes showed the need to use properties as a function of temperature, so it is as close as possible to a real material; high heating rates (≥ 50°C/h) are viable for linings with small thickness (< 20 cm); the withdrawal of free water at plateaus with temperatures below, but close to, the temperature of the beginning of the hydrate decomposition process enables the use of short plateaus at higher temperatures, speeding the drying process. Finally, using indicators such as drying status, resistance ratio and energy consumption, it was possible to compare the curves with each other to choose the one that best meets the needs of the end-user.
Valorização da propriedade rural: uma análise comparativa das diferentes formas de valorização aplicados a imóveis rurais no município de Angatuba-SP
(Universidade Federal de São Carlos, 2022-03-21)
Verardi, João Paulo
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Santos, Leandro de Lima
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https://lattes.cnpq.br/2750978055015275
This work addresses the existence of different forms of property valorization, as they are attributed at different times: one from the calculation of the Real Value, which is given at the time of contributing as the government through the collection of taxes and taxes, also through the calculation of the Market Value in the marketing and collection of resources such as financing, being obtained, for analysis purposes, from primary and secondary data. The data obtained primarily are based on the use of the proposed method for NBR 14.653 on a rural property selected by the author of this work, and contrasted with the value obtained through the Venal Value Calculator of the Institute of Agricultural Economics (IEA). For the secondary data, an analysis was carried out based on information obtained from the real estate agencies of the municipality of Angatuba in contrast to the values measured in the Municipal Decree of Angatuba No 519/2021. The results obtained point to a higher valuation of the property by defining the Market Value of the property, which is used for example as a guarantee in financing, and to undervaluation of the property measured from the Market Value, used, for example, for property payments. imposts and transfer or declaration of benefits. Finally, it was discussed the practical result of the possible contrast between the Sales Value and Market Value of the property.
Potencial antifúngico de nanoemulsões de óleo essencial de Cravo-da-Índia (Syzygium aromaticum)
(Universidade Federal de São Carlos, 2022-03-22)
Cipriano, Lavinia
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Ferreira, Marcos David
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https://lattes.cnpq.br/6652079760634274
;
Sousa, Cristina Paiva de
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https://lattes.cnpq.br/9002619114161319
Essential oils are extracts derived from plants, defined as secondary metabolites compounds, being an important defense mechanism of plants. The antimicrobial activity of the oils is mainly due to their hydrophobic nature, and it is believed that this activity against bacteria and fungi is directly related to the major compounds present in the essential oil. Clove (Syzygium aromaticum) is a plant native to Indonesia, with an extensive literature record of the activity of clove essential oil against bacteria and fungi. Phytopathogenic fungi that attack crops after harvest are responsible for the loss of tons of crops worldwide. In tropical regions, Penicillium spp. and Rhizopus stolonifer have a high incidence, and cause diseases known as “Green Rot” and “Black Rot”, respectively. The use and application of essential oils in their pure form has some limitations, such as their volatility, high reactivity and hydrophobicity, making their direct incorporation into foods difficult. In order to maintain their biological properties and reduce the impact of their application on food, the oils were incorporated into emulsions and nanoemulsions to later be encapsulated. Materials and methods: The production and characterization of nanoemulsions with Clove EO was carried out, after the determination of the Hydrophilic-Lipophilic Balance (HLB), from the mixture between aqueous and organic phase, consisting of the EO and a mix of surfactant composed by Tween 80 and Span 80. After characterization, a comparison was made between the antifungal activity of the pure essential oil, emulsion and nanoemulsion against postharvest fungi Penicillium spp. and Rhizopus stolonifer. Results: After the determination of the BHL, a nanoemulsion with a particle size of 50 d.nm was produced. From the antifungal activity tests, it is concluded that the nanoemulsion did not increase the essential oil activity against the tested fungi, being the oil in its pure form more efficient than the emulsion and nanoemulsion.
An analysis of the relationship between additive manufacturing and circular economy
(Universidade Federal de São Carlos, 2022-03-22)
Tavares, Thais Moreira
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Godinho Filho, Moacir
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Ganga, Gilberto Miller Devós
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https://lattes.cnpq.br/9062191157466610
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https://lattes.cnpq.br/4310619949372745
Additive Manufacturing (AM) is an important technology of Industry 4.0. It allows the fabrication of objects layer by layer in a continuous or incremental way. Circular Economy (CE) aims to improve resource efficiency in order to lead to a shift from the current linear model of receiving, transforming and disposing to a model where resources flow in a circular manner. Some early studies refer to Additive Manufacturing as a promise of sustainability and development of more circular material flows. However, there is still uncertainty about the impacts and benefits of Additive Manufacturing for circularity. From this context, this work aims firstly to understand the relationship between additive manufacturing and circular economy. To achieve this goal, a multi-method study was carried out to understand how AM is beneficial or challenging in a Circular Economy context. Second, it aims to collaborate in the implementation of AM strategies in an EC context. To coordinate the elaboration of the strategies, a second multi-method study was carried out, using a fuzzy DEMATEL method. This method was used to understand the interdependence relationships between the barriers raised in the first study. The study of these relationships is essential in the elaboration of strategies for implementing a more circular AM. The research contributes to practice and theory. In theory, it elaborates the state of the art of the intersection between the themes, evolving into a framework addressing benefits and barriers (validated by experts) that AM brings to CE. The study also contributes to practice by showing to organizations what developments and strategies need to take place to smooth the way for a circular AM.
Alterações genéticas associadas ao gene apoe em pessoas com declínio cognitivo subjetivo (DCS): uma revisão sistemática
(Universidade Federal de São Carlos, 2022-03-22)
Fernandes, Carla Nunes Fonseca
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Cunha, Anderson Ferreira da
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https://lattes.cnpq.br/0329741640375661
;
Vale, Francisco de Assis Carvalho do
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https://lattes.cnpq.br/7135183635933470
Subjective cognitive decline (SCD) consists of a self-perception of cognitive decline, with no objective impairment on cognitive tests and no functional impairment in activities of daily living. It represents a transitional stage between the asymptomatic state and the impairment of cognitive functions. Studies indicate that neurobiological bases participate in the process of the loss of cognitive function in the early stages of SCD. There is evidence that the neurobiological processes are related to polymorphisms in different nucleotide positions of the gene that codes for apolipoprotein E (APOE), changing the sequence of the original amino acids and modifying its structural properties. It is therefore believed that these alterations may influence the functional properties of APOE and promote the accumulation of β-amyloid plaques and the formation of neurofibrillary tangles. The molecular and physiological mechanisms leading to these clinical conditions are not yet known in detail, and therefore correlating the studies already developed aimed at further exploring these questions are critical. We performed a data collection that relates the APOE gene with DCS, through the libraries: PubMed, Mendeley and Web of Science, in the period from June to August 2021. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) model was used to construct this systematic review. Ninety studies were identified, of which only 34 met the inclusion criteria. Fifty-six studies were excluded by the following criteria: no characteristics related to DCS and APOE genotype, animal research, systematic review or meta-analysis, other genetic biomarker, protein receptor or hormonal factor, book chapter, DCS or APOE related to another disease or early onset AD, which is not associated with APOE as a risk factor, or articles that do not deal with the pre-clinical phase or year less than the stipulated date of the study. The related data pointed out in this literature review corroborate the literature in the possible existence of a clear relationship between DCS and the APOE genotype specifically in the ε4 allele in memory impairment in its early stages
Agricultura familiar e crédito via PRONAF: fatores determinantes da utilização nas regiões Serrana, Norte e Noroeste do Rio de Janeiro
(Universidade Federal de São Carlos, 2022-03-23)
Almeida, Claudio Cezar
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Batalha, Mario Otávio
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https://lattes.cnpq.br/1015001063418091
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https://lattes.cnpq.br/6717374300414740
Family farming is of great importance to the Brazilian economy, due to its participation in food production and its ability to employ labor. Also, in Rio de Janeiro, family farming is highlighted, especially in the Mountain, Northern and Northwest regions. However, throughout Brazil, family farming faces important challenges to fully exploit its potential. The credit is among these challenges. For family farmers, credit is a vitally important element. With this perspective and aiming to strengthen the granting of credit under conditions consistent with the reality of family farming, the federal government created in 1996 the National Program for Family Agriculture (PRONAF). This program has played an important role in providing credit for family farmers throughout Brazil. In eight months of the 2021/2022 harvest, 1,274 thousand rural credit contracts were financed, corresponding to an amount of R$ 188.4 billion (BRASIL, 2022). However, in some regions it is less used than in others. In the northeast, for example, only 7.3% of family farmers accessed PRONAF in 2016, while in the southern region this percentage reaches 48.8% (IBGE, 2017). This is the case, for example, of the regions studied in this thesis. Without having the objective of making a comparative study between regions of Brazil, it is important to know which factors can best explain the raising of credit, via PRONAF, by farmers in the Mountain, Northern and Northwest regions of the State of Rio de Janeiro. Thus, this work has as main objective to identify determining factors of access to rural credit by family farmers located in the Mountain, North and Northwest regions of the State of Rio de Janeiro. To achieve this objective, were used primary data collected through face-to-face interviews in 499 households, distributed in the three regions. These data were analyzed in a logistic linear regression model, built from a set of hypotheses that are based on a conceptual model built with theoretical elements of the Resource-Based View and the Transaction Cost Theory. The results obtained through the econometric model made it possible to confirm the identification of four factors (marital status of the family farmer, the share of the value of rural production in the total income of the property, the availability of guarantees and access to technical assistance) as determining factors of access to PRONAF credit by family farmers in the state of Rio de Janeiro, in addition to providing subsidies to suggest measures related to rural credit and improvements in the management of properties and production processes of family farmers.
Atomização a gás do aço ferramenta A2: efeito dos parâmetros de processo nas características do pó
(Universidade Federal de São Carlos, 2022-03-23)
Mathias, Laura Emi Tavoni
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Gargarella, Piter
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https://lattes.cnpq.br/4641435644243916
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https://lattes.cnpq.br/6497697599064366
Gas atomization is the main method in powder metallurgy to produce powders for additive manufacturing (AM). The gas atomization process allows generally spherical and very fine metallic powders with great yield on the particle size range for AM applications. Moreover, this is a rapid solidification process that ensures chemical homogeneity and a high degree of microstructural refinement. Iron-based alloys have wide properties range and low cost, in which tool steels are especially important for industrial applications. This project produced A2 tool steel powders by gas atomization and evaluated the influence of the process parameters on the characteristics of the powders. No systematic study has been carried out on atomization and AM of this tool steel. Thus, analyzing the gas atomization process of this material is important to ensure the production of powders with proper characteristics. The statistical tool of design of experimental (DOE) was applied, and the atomization pressure and melt superheat process parameters were analyzed. The response variables analyzed were morphology, median particle size, particle size distribution, density and flowability. The powder characterization was done by laser diffraction, sieving, scanning electron microscopy, chemical analyses by EDS, flowability by Hall and Carney Flowmeter Funnel, density by helium pycnometry and apparent density. This study showed that the gas atomization process of the A2 tool steel was suitable for the production of powders for applications in AM. The model proposed by Lubanska, which formulate the mass median particle diameter, was also validated. Furthermore, the process with the lowest pressure level (20Bar) and the highest melt superheat (300K) has the lowest gas/metal ratio and mean particle size (D50) and particle size distribution similar to the other powders produced.