Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients

Thumbnail Image

Files

NIV acutely improves endothelial function in exacerbated COPD.xlsx (20.42 KB)

Date

2021-05-01

Authors






Journal Title

Journal ISSN

Volume Title

Publisher

Universidade Federal de São Carlos

DOI

Abstract

Description

Purpose: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with an elevated risk of cardiovascular events, which can be linked to endothelial dysfunction. In this study, we aimed to investigate whether noninvasive ventilation (NIV) acutely changes endothelial function in hospitalized AECOPD patients. Methods: Twenty-one AECOPD patients were assessed in a hospital ward setting from 24 to 48 h after admission. NIV was applied using a ventilator with bilevel pressure support. Before and after NIV protocol, patients were evaluated regarding (1) endothelium-dependent function, assessed non-invasively using the flow-mediated dilation (FMD) method; (2) arterial blood gas analysis. Other baseline evaluations included clinical and anthropometric data, and laboratory tests. Results: The total group showed a significant improvement in FMD as a result of NIV effect (P = 0.010). While arterial carbon dioxide and oxygen were not altered, oxygen saturation increased after NIV (P = 0.045). The subgroup comparison of responders (FMD ≥ 1%) and non-responders (FMD < 1%) showed significant baseline differences in body mass index (BMI) (P = 0.019) and predicted forced expiratory volume in one second (FEV1) (P = 0.007). In univariate and multivariate analyses, both BMI and FEV1 were determinant for endothelial response to NIV. Conclusion: NIV acutely improves endothelial function in hospitalized AECOPD patients. Overweight and COPD severity may represent important characteristics for the magnitude of peripheral vascular response.

Keywords

Chronic obstructive pulmonary disease , Noninvasive ventilation , Peripheral vascular function

Citation

HEUBEL, Alessandro Domingues; KABBACH, Erika Zavaglia; SCHAFAUSER, Nathany Souza; DI LORENZO, Valéria Amorim Pires; SILVA, Audrey Borghi; MENDES, Renata Gonçalves. Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients. Repositório Institucional da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/20.500.14289/15555.

URI

https://repositorio.ufscar.br/handle/20.500.14289/15555

Collections

Projetos FAPESP

Endorsement

Review

Supplemented By

Referenced By

Creative Commons license

Attribution-NonCommercial-NoDerivs 3.0 Brazil
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Brazil