Compósito a base de hidroxiapatita com ação antimicrobiana

Abstract

The development of materials that have antimicrobial properties are increasingly highlighted in the academic environment. In this way, the use of hydroxyapatite (HAp) as a support for semiconductors and natural compounds for application in biological systems becomes of extreme interest due to its known antimicrobial action. the proportion of α-Ag2WO4 and the presence of curcumin were varied, hoping that the materials obtained would have antimicrobial activity. To make this compound viable, the hydroxyapatite was synthesized by means of a co-precipitation in reflux with strict temperature and pH controls, then by an in situ synthesis, we had to obtain the silver supported on hydroxyapatite by means of the sonochemical method and finally it was performed the anchoring of curcumin, obtaining, therefore, the final material and carrying out the characterization of the samples in XRD, FT-IR and SEM. The results obtained were promising, since by the diffractogram it was observed that a phase related to α-Ag2WO4 was obtained, as well as in the infrared spectroscopy bands related to curcumin were observed, in addition, the material proved to be efficient against the fungus C. albicans, especially the HAp-AWO-30%-Cur samples, which in small concentrations had 99.0% efficiency against fungal species. Against another types of vitruses and bacterials , this material can be effective and usable in bone and odontological implants.