Efeito da celulose bacteriana como enxerto no reparo tecidual e revascularização após queimaduras cutâneas em modelo animal: um protocolo para uma revisão sistemática

Abstract

INTRODUCTION: Skin burn injuries often cause death and long-term disability, and multiple articles are available in the literature presenting applications of bacterial cellulose for skin wound healing. The use of biomaterials for wound repair is among the most promising approaches, promoting the development of different dressings. Currently, there is a variety of dressing materials that are used for wound treatment, such as films, foams, hydrocolloids, and hydrogels. A widely used and studied example of hydrogel is bacterial cellulose (BC). BC is a natural polymer, synthesized by several bacteria, which has favorable characteristics to be applied in wounds. OBJECTIVE: To develop a protocol for a systematic review of the effect of bacterial cellulose as a graft on tissue repair and revascularization after skin burns in an animal model. METHOD: Following PRISMA guidelines and Cochrane recommendations, an electronic search will be performed in Medline/PubMed, Embase, and Web of Science databases for relevant articles published up to August 2022. Only preclinical trials comparing bacterial cellulose treatment to a control or placebo group will be considered eligible for inclusion. Study screening and data extraction will be performed by two authors. The methodological quality of the primary studies will be assessed using the SYRCLE's RoB tool for animal studies. The quality of evidence for each summarized outcome measure will be assessed using the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) approach. RESULTS: The results of this study will be submitted to a peer-reviewed journal for publication. CONCLUSION: The present protocol will assist in the elaboration of a future systematic review, addressing the effectiveness of bacterial cellulose as a graft in tissue repair and revascularization of skin burns in animals experimental.