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Otimização da biossecagem pulsante da biomassa de laranja em leito fixo
(Universidade Federal de São Carlos, 2026-07-06)
Freitas, Cauê Zenatti Fernandes de
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Maia, Gustavo Dias
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http://lattes.cnpq.br/3804133304643228
This study evaluated the effects of intermittent air flow on the thermal development and moisture removal during the biodrying process, aiming at the valorization of industrial biomass. The experiments were carried out in a fixed-bed bios drying experimental unit, with monitoring of bed temperature, air flow rate, and mass loss. The results demonstrated that increasing the air flow rate enhanced mass transfer and water removal from the material; however, its effect was directly related to the initial conditions of the system, such as the level of biological activity. It was observed that higher air flow rates did not necessarily result in greater drying efficiency, highlighting the importance of balancing heat transfer, moisture removal, and microbial activity. Furthermore, the analysis of the experiments indicated that biological heat generation, even from native microorganisms, has the potential to sustain the thermal conditions of the process. Therefore, it is concluded that bios drying presents potential as a sustainable alternative for the pre-treatment of orange bagasse, contributing to biomass moisture reduction and expanding its possibilities for energy applications.
Tecnologias da indústria 5.0 aplicadas à cadeia do biometano: potencializando a transição energética e o desenvolvimento socioeconômico no Brasil
(Universidade Federal de São Carlos, 2026-07-06)
Nogueira, Letícia Requena Ruiz
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Horta, Antonio Carlos Luperni
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http://lattes.cnpq.br/5923938048634505
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https://orcid.org/0000-0002-3042-0351
The global energy transition landscape demands the mitigation of greenhouse gas emissions and the consequent diversification of the fuel mix. Currently, biomethane stands out as a strategic solution obtained through biogas purification. However, the biomethane industry faces regulatory and economic challenges that limit its competitiveness against fossil alternatives. In this context, this work aimed to evaluate the technical, economic, and environmental feasibility of biomethane production from municipal solid waste in the municipality of São Carlos (SP). The present study was carried out within the Industry 5.0 framework, a paradigm that integrates advanced automation and digital technology not only to increase productivity but also to ensure that industrial development is guided by sustainability, resilience, and social well-being. The purification process was simulated using Pressure Swing Adsorption (PSA) technology, aiming for compliance with ANP Resolution No. 886/2022 for vehicular use. The findings demonstrated that the system achieves high selectivity, corroborated by an economic analysis that confirmed the venture's viability through positive financial indicators. Although some sustainability indicators reveal opportunities for future optimization, the consolidated analysis points out that integrating digital and sustainable technologies, grounded in Industry 5.0, transforms waste management into a strategic asset for the energy transition and socioeconomic development in Brazil.
Avaliação de custos acerca da transição de eficiência energética em transformadores de distribuição: um estudo comparativo entre as tecnologias de núcleo empilhado e jencore
(Universidade Federal de São Carlos, 2026-07-06)
Tagliarini, Bruno
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Pizolato Junior, José Carlos
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http://lattes.cnpq.br/4338949783568483
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https://orcid.org/0000-0002-3372-7092
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http://lattes.cnpq.br/4610884326389037
The contemporary scenario of energy transition and the search for sustainability has intensified the demand for more efficient transformers, given that the efficiency of these devices directly affects electrical losses in distribution networks. In light of the imminent change in manufacturing guidelines established by Brazilian regulatory bodies, which mandate the transition of energy distribution transformer efficiency classes, a problem arises regarding the impact on manufacturing costs for Brazilian manufacturers. This study is justified by the need to understand the resulting financial increase, aiming to guide a national company to maintain market competitiveness while balancing production costs and regulatory requirements. The general objective is to analyze the budgetary impact of the transition between efficiency classes “C” and “B” in the production of 45 and 75 kVA distribution transformers, by comparing two distinct types of ferromagnetic cores: stacked and jencore. The methodology consisted of electromechanical design utilizing spreadsheet calculation tools and a quantitative cost assessment based on the direct production cost (CDP), accounting for materials and labor in the production processes. The study identified that the transition to Class B using a stacked core proved to be more viable for the 75 kVA power transformers, whereas the jencore technology is more advantageous for the 45 kVA equipment. The increase in production cost for Class B transformers ranged between 17.27% and 35.29%, with silicon steel being the raw material with the highest financial impact on the transformer.
Indicadores de sustentabilidade na cadeia produtiva do café sob a perspectiva da indústria 5.0
(Universidade Federal de São Carlos, 2026-07-06)
Oliveira, Ana Beatriz de
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Horta, Antonio Carlos Luperni
;
http://lattes.cnpq.br/5923938048634505
;
https://orcid.org/0000-0002-3042-0351
Coffee plays a major role in the Brazilian economic system, being one of the main products of the national agribusiness sector and highly relevant to both the domestic market and exports. Beyond Brazil, coffee is also a globally significant commodity, with the main producing countries being Brazil, Vietnam, Colombia, Indonesia, and Ethiopia. In Brazil, the most commonly cultivated species are Arabica coffee (Coffea arabica) and Robusta or Conilon coffee (Coffea canephora). The quality of the final beverage is influenced by factors ranging from bean harvesting to post-processing stages, such as roasting and grinding. In general, coffee processing consists of the following stages: harvesting, preparation, drying, storage, roasting, grinding, packaging, and commercialization. Given the importance of this sector, there is a growing need to adopt sustainable practices throughout the coffee supply chain, which has driven the implementation of sustainability indicators capable of measuring environmental, social, and economic impacts, thereby promoting greater transparency and efficiency in production processes. In this context, the Industry 5.0 perspective has gained prominence by integrating advanced technologies with human-centered values and sustainability principles. This approach enables more accurate monitoring, supports strategic decision-making, and contributes to the development of a more resilient production chain that is better aligned with the needs of society and the environment.
Tratamentos combinados para resíduos de 2,4-d, picloram e aminopiralide como alternativa para evitar incinerações
(Universidade Federal de São Carlos, 2026-07-06)
Falcão, Thiago Vinicius Porcel
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Silva, Edson Luiz
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http://lattes.cnpq.br/9720274214573371
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https://orcid.org/0000-0003-3194-4912
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http://lattes.cnpq.br/9857184404356864
Agriculture is essential for the global food supply, and its productivity increased with the Green Revolution, which enabled the use of agricultural pesticides. Brazil is one of the world's largest grain producers and exporters; in the 2024/2025 crop season, the country achieved a record production of approximately 350,206 thousand tonnes. This growth is driven by intensive cultivation, which helps protect native areas; however, such high productivity creates a strong reliance on agrochemicals. Brazil has become the world's largest consumer of these substances, using 800,652 tonnes. Maintaining the production chain generates effluents that can impact the environment; these effluents contain active ingredients such as 2,4-D (2,4-dichlorophenoxyacetic acid), Picloram, and Aminopyralid. Currently, the treatment of these liquid wastes—originating from batch formulation processes and equipment decontamination—relies in some cases on incineration. Although incineration breaks down the chemical stability of aromatic rings, it has disadvantages, such as high operating costs and greenhouse gas emissions. This undergraduate project sought to identify a technical alternative to incineration for treating liquid wastes containing the herbicides 2,4-D, Picloram, and Aminopyralid at an industrial facility in the state of São Paulo. The research was qualitative and descriptive, conducted through a case study. Based on an analysis of the active ingredients' physicochemical properties and the mechanisms of alternative processes, an integrated treatment route was identified. The proposal involved the sequential application of a Membrane Separation Process (MSP) to concentrate the effluent, followed by Advanced Oxidation Processes (AOPs) to break down the aromatic ring structures and convert them into biodegradable linear intermediates; the treatment concluded with a biological (microbiological) process to metabolize the compounds, followed by the polishing of remaining traces via adsorption.
Bioprospecção de rizobactérias com potencial de mitigação a Candidatus Liberibacter asiaticus e ao HLB
(Universidade Federal de São Carlos, 2026-07-06)
Volponi, Alessia Zincone
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Lima, Helena Santiago
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http://lattes.cnpq.br/8307191971212434
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https://orcid.org/0000-0001-6709-2745
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Coletta Filho, Helvécio Della
Among the major citrus diseases currently occurring in the state of São Paulo, Brazil, Huanglongbing (HLB), caused by the bacterium Candidatus Liberibacter asiaticus (CLas), is considered the most damaging to citrus production. To date, CLas has not been successfully cultured under axenic conditions outside its hosts (plants and Diaphorina citri), which has greatly hindered research on this pathogen. Genetically related and culturable microorganisms, such as Sinorhizobium meliloti (Sme) and Liberibacter crescens, have been used as model organisms in vitro to identify antimicrobial compounds and microbial antagonists against CLas. However, efficient screening strategies require both rapid in vitro approaches and in situ methods capable of directly evaluating the behavior of potential antagonists against CLas. The objective of this study was to select and evaluate bacterial genera previously described as antagonistic to phytopathogens for their potential activity against CLas. For this purpose, we had as goals: i. Conduct in vitro antagonism assays using S. meliloti as a model organism. ii. Evaluate the selected isolates over CLas titer and the plant physiological development in infected plants under greenhouse conditions. A total of 274 bacterial isolates were screened, of which 18 exhibited inhibitory activity, belonging to the genera Bacillus, Burkholderia, Lelliottia, Methylobacterium, Serratia, and Pseudomonas. Selected isolates were subsequently evaluated in CLas-infected citrus plants. Pathogen quantification was performed by qPCR in leaves and roots, together with assessments of plant growth characteristics. The results demonstrated that several isolates significantly reduced CLas titers during the experimental period. Among them, Methylobacterium_IAC80 was the most promising, reducing bacterial populations in both leaves and roots while also promoting plant growth. The isolates Serratia_IAC568, Lelliottia_IAC75, Pseudomonas_IAC532, and Bacillus_IAC362 also showed potential to reduce CLas populations in leaves, exhibiting performance equal or superior to oxytetracycline without causing negative effects on plant development.
Cooperativismo de plataforma: uma análise da federação nacional das cooperativas de mobilidade urbana (Liga Coop)
(Universidade Federal de São Carlos, 2026-07-06)
Carneiro, Ludmila
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Pires, Aline Suelen
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http://lattes.cnpq.br/8860270341724853
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https://orcid.org/0000-0001-5932-1050
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http://lattes.cnpq.br/5316871548589738
Over the past decade, we have witnessed the spread of digital service platforms worldwide. In this context, the processes of uberization, which point to the intensification of informalization and precariousness of work, and platformization, which reflects a growing dependence on digital platforms, have profoundly affected contemporary social and labor dynamics. In response to this scenario, platform cooperativism has emerged as an alternative based on principles of self-management, decent work, and the valorization of collectivity, yet still marked by limitations and contradictions within the capitalist system. Given the novelty of platform cooperatives and the need to expand knowledge about these initiatives in Brazil, our research focused on a cooperative federation of drivers founded in 2023, the Federação Nacional das Cooperativas de Mobilidade Urbana (Liga Coop). This research aimed to analyze the organizational forms of Liga Coop and the resources the federation has been mobilizing to confront the working conditions imposed by major digital platforms such as Uber. Methodologically, the study was based on qualitative research, including semi-structured interviews, observation, and document analysis. The results indicate that Liga Coop is developing rapidly, but is marked by instabilities and negotiations between cooperative principles, market demands, and the material conditions of operation. Its forms of resistance are expressed through the collective reorganization of dimensions of work unilaterally controlled by platforms, as well as through the ambivalent practices of workers who combine the cooperative model with conventional apps.
Indicadores da saúde do solo em sistemas integrados lavoura-pecuária-floresta: atividades das enzimas β-glicosidase e arilsulfatase e modelagem preditiva por Infravermelho Próximo (NIRS)
(Universidade Federal de São Carlos, 2026-07-06)
Napolitano, Vitoria
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Fuentes, Andrea Soares da Costa
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http://lattes.cnpq.br/2426157257540389
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https://orcid.org/0000-0002-7379-1136
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Martin Neto, Ladislau
Soil organic carbon is one of the main components associated with the quality and functionality of terrestrial ecosystems, directly influencing microbial activity, nutrient cycling, and the stability of organic matter. In this context, soil enzymes such as β-glycosidase (BG) and arylsulfatase (ARYL) stand out as bioindicators sensitive to management-induced changes, as they are related, respectively, to the carbon and sulfur cycles. The objective of this study was to evaluate biochemical, spectroscopic, and soil carbon indicators in long-term integrated crop-livestock-forestry (SILPF) systems conducted at Embrapa Pecuária Sudeste in São Carlos, São Paulo. A total of 114 soil samples were analyzed, collected from the 0–10 cm layer in ILPF systems with different variations, including: the complete system, with all components, that is, integrated crop-livestock-forestry (ILPF); livestock-forestry (IPF) system; crop-livestock (ILP) system; intensive pasture (INT); extensive pasture (EXT); and native forest (FLO), used as a reference area. BG and ARYL activities were determined chemically by measuring the release of p-nitrophenol; total carbon was determined by CHN elemental analysis; the humification index of soil organic matter (HLIFS) was assessed by laser-induced fluorescence; and the average specific enzyme activity (ASEA) was calculated from enzyme activities normalized by soil carbon. In addition, near-infrared (NIRS) spectra were obtained to assess the technique’s potential for estimating biochemical attributes and soil carbon. The highest BG activity was observed in the ILP system, with a mean of 155.91 μg pNP g⁻¹ soil h⁻¹, followed by the INT system, with 105.64 μg pNP g⁻¹ soil h⁻¹, while the EXT system had the lowest value, at 63.17 μg pNP g⁻¹ soil h⁻¹. For ARYL, the FLO treatment showed the highest mean value, at 745.5 μg pNP g⁻¹ soil h⁻¹, followed by the INT treatment, at 475.8 μg pNP g⁻¹ soil h⁻¹, while the EXT treatment showed low activity, at 191.3 μg pNP g⁻¹ soil h⁻¹. In general, systems with a tree component exhibited lower enzymatic activities compared to ILP, INT, and FLO. ASEA was highest in FLO (13.22), followed by INT (11.71) and ILP (8.83), indicating higher enzymatic activity relative to available carbon in these systems. FLO had the lowest HLIFS (1350.1), while the EXT pasture had the highest HLIFS (3935.4), highlighting differences in the degree of organic matter transformation among the evaluated systems. The models obtained by NIRS showed an R² of 0.39 and an RMSECV of 22.42 for BG, and an R² of 0.72 and an RMSECV of 83.8 for ARYL, indicating better predictive performance for arylsulfatase. Overall, the integration of enzymes, total carbon, HLIFS, ASEA, and NIRS allowed for a more comprehensive assessment of soil health, indicating that conservation-based management systems with higher plant biomass favor soil biochemical quality.
Conectividade funcional potencial em paisagens antropizadas: estrutura de resistência de caminhos de menor custo no retorno de Melipona quadrifasciata
(Universidade Federal de São Carlos, 2026-07-06)
Furlan, Letícia Oliveira
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Toppa, Rogério Hartung
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http://lattes.cnpq.br/0673898572494729
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https://orcid.org/0000-0002-1637-2840
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http://lattes.cnpq.br/6221657747133329
Habitat fragmentation and the expansion of anthropogenic areas can compromise pollinator functional connectivity by altering landscape permeability and hindering their movement and survival. In this context, this study evaluated the functional connectivity of the native stingless bee Melipona quadrifasciata, commonly known as “mandaçaia”, in an anthropized landscape, investigating the influence of distance, seasonality, and the characteristics of potential corridors on bee return success and return speed. Release experiments were conducted during the four seasons of the year at five distances ranging from 500 to 2,500 m from the colony and were integrated with ecological corridor modeling based on least-cost paths generated from resistance surfaces built using land-use and land-cover data and the Normalized Difference Vegetation Index (NDVI). A total of 240 releases were performed, 60 in each season, of which 155 resulted in successful returns to the colony (64.6%). Return probability decreased significantly with increasing distance, ranging from approximately 79% at 500 m to 46% at 2,500 m, highlighting distance as the main limiting factor for movement. Seasonal differences were also observed, with lower return rates and slower return speeds in autumn and better performance during spring and summer. Potential corridors showed high spatial stability across seasons, with similarity indices exceeding 0.91 and maximum recurrence covering 87.36% of the total corridor area. However, the functionality of these corridors varied over time. Distance was the main factor associated with the probability of return, whereas landscape heterogeneity influenced the speed at which bees returned to the colony. The results indicate that the functional connectivity of M. quadrifasciata depends primarily on displacement distance but is also influenced by matrix functional quality and landscape heterogeneity. These findings reinforce the importance of simultaneously considering species movement capacity and matrix permeability in conservation strategies and landscape planning.
A violência psicológica sofrida por trabalhadores de limpeza de uma empresa terceirizada em universidade pública
(Universidade Federal de São Carlos, 2026-07-07)
Pejon, Laura Ferratti
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Brino, Rachel de Faria
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http://lattes.cnpq.br/0235133592567485
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http://orcid.org/0000-0003-23492864
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http://lattes.cnpq.br/2004336011686224
Over the past three decades, the phenomenon of outsourcing has structurally altered Brazil's productive base, defining new forms of contracting and inter-company relationships while significantly increasing the precariousness of working conditions in the country. This study aimed to identify and characterize the psychological violence experienced by outsourced cleaning staff at a public university, as well as to analyze the physical and psychological consequences of this phenomenon and the various parties involved—the outsourcing company, the university, and the institution's users. Seven outsourced cleaning workers, all over the age of 18 and employed at the public university for more than three months, participated in the research. Data were collected through semi-structured interviews and analyzed using Reflexive Thematic Analysis. The accounts revealed instances of psychological violence perpetrated by various actors, alongside several factors impacting the workers' physical and psychological health, such as the precarious nature of outsourced work, interactions with the university community, and a lack of support from official protection networks. Future studies should focus on developing intervention strategies for this population and raising awareness about this phenomenon within the university environment.
O bem-viver de universitários indígenas: desafios e oportunidade na universidade pública federal
(Universidade Federal de São Carlos, 2026-07-07)
Ladino, Cauana Maia
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Fioroni, Luciana Nogueira
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http://lattes.cnpq.br/8086810053892035
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https://orcid.org/0000-0002-2311-7848
;
Tariano
The inclusion of Indigenous people in Brazilian public higher education is a recent development, becoming the focus of more robust federal public policies starting in 2007. This study investigated the experiences of Indigenous university students at UFSCar regarding their integration into the academic environment and its relationship to student retention, using the concept of *Bem-Viver* (Good Living) as a central framework. The methodological approach is empirical and qualitative-interpretative, utilizing a semi-structured interview guide and the "Five Fields Map" tool. Thirteen Indigenous university students were interviewed, and eight completed the Five Fields Map. Thematic analysis identified three empirical categories: i) protective factors (the university, emotional bonds, self-recognition); ii) risk factors (family/cultural separation, student retention challenges, violence, and racism); and iii) factors promoting *Bem-Viver* (sense of belonging, cultural expressions, and connection to nature and ancestry). Family support and the strengthening of ethnic identity emerged as key protective factors, fostering resilience within the academic model. Conversely, the text details critical risk factors, including financial vulnerability, cultural isolation, and the severe impact of structural racism. Student retention relies on a socio-affective support network and affirmative action policies that respect ancestral knowledge. Ultimately, Indigenous academic success transcends the individual degree, representing a political and collective achievement for Indigenous peoples.
Experiências religiosas coercitivas na infância em famílias católicas brasileiras: estudo exploratório
(Universidade Federal de São Carlos, 2026-07-07)
Martins, Juliana Garcia
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Brino, Rachel de Faria
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http://lattes.cnpq.br/0235133592567485
;
http://orcid.org/0000-0003-23492864
;
http://lattes.cnpq.br/1830190795108415
This study aimed to understand religious experiences during childhood within Brazilian Catholic families, interpreting them through the lens of the concept of coercion proposed by Sidman (1989/2009). It is an exploratory, descriptive study using a qualitative approach, conducted via an online questionnaire comprising closed sections (sociodemographic data and twenty 5-point Likert-scale items) and six open-ended questions. Participants included 61 adults aged 18 to 28 (M = 23.08), recruited through convenience sampling and the snowball technique. Sociodemographic data and closed-ended questions were analyzed descriptively, while responses to open-ended questions were organized by recurring themes and interpreted based on the coercion framework. The results revealed significant diversity in the reported experiences: part of the sample described family religiosity as a source of acceptance and bond-strengthening, whereas another segment reported experiences marked by fear, guilt, divine punishment, and restricted autonomy—often associated with emotional distress and subsequent withdrawal from religious practice. The analyses suggest that the impact of religious transmission during childhood stems not from the practices themselves, but from the behavioral contingencies (positive reinforcement or aversive control) that sustain them. This study contributes to expanding a field that remains under-explored in Brazilian literature regarding coercive religious experiences.
Efeito da massa do leito na biossecagem pulsante de biomassa de laranja
(Universidade Federal de São Carlos, 2026-07-07)
Bueno, Matheus Rodrigues
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Maia, Gustavo Dias
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http://lattes.cnpq.br/3804133304643228
The citrus industry, especially orange production, is highly relevant to the global economic landscape, with Brazil standing out as the leading producer in the 2024/2025 harvest, reaching approximately 13 million tons, representing about 29% of world production. In this context, an important opportunity for improvement in waste management and valorization is evident, since the production of juice and its derivatives generates large quantities of solid waste with high moisture content, intensifying the dependence on drying processes for storage and utilization of these byproducts. Given this scenario, biodrying emerges as a promising alternative for optimizing this process. This study aimed to analyze the effect of different masses of orange solid waste in the bed on the performance of intermittent biodrying with periodic air pulses, seeking to understand the influence of this variable on the process efficiency. The experiments were conducted on a laboratory scale using a fixed-bed biodryer with three masses of residue (2, 4, and 6 kg) and three aeration profiles (15 min/1 h, 15 min/3 h, and 45 min/1 h), maintaining a constant air flow rate of 2.0 m³/h over 72 hours. Temperature and humidity profiles were monitored during the process. The results indicated that beds with higher mass presented higher average temperatures, suggesting greater microbial activity. Regarding humidity, it was observed that the final content was influenced by the degree of contact between the air and the biomass, with better performance associated with longer aeration times. Additionally, it was found that the bed mass impacts the airflow distribution, with bypass observed in beds with lower mass and better air percolation in beds with higher load, which contributed to increased process efficiency.
Abordagem sociointeracionista sobre o estudo dos cinco sentidos a partir de uma proposta interdisciplinar voltada para estudantes do Ensino Fundamental dos anos finais
(Universidade Federal de São Carlos, 2026-07-07)
Fonseca, Isadora Tonscheis da
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Silva, Adriana de Oliveira Delgado
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http://lattes.cnpq.br/2707979913713089
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http://lattes.cnpq.br/0595079886266650
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Moraes, Letícia Estevão
This study aims to develop and analyze a didactic sequence on the sensory system based on a socio-interactionist and interdisciplinary approach. Considering the guidelines established by the Brazilian National Common Curricular Base (BNCC), the study discusses the need to overcome fragmentation in Natural Sciences teaching by integrating concepts from physics, chemistry, and biology in the study of the five senses. The theoretical framework is grounded in Lev Vygotsky’s Historical-Cultural Theory, with emphasis on the concepts of social interaction, Zone of Proximal Development, and the more knowledgeable other. In addition, the main biological, physical, and chemical aspects involved in the functioning of the sensory system are presented. As an educational product, a didactic sequence was developed, including expository, investigative, and experimental activities organized to promote collaborative work. The proposal was implemented in sixth-grade classes, enabling the observation of student interactions and their relationship with learning. The results indicate that the didactic sequence contributed to knowledge construction, while also promoting student engagement and the development of socio-emotional skills. It is concluded that the articulation between interdisciplinarity and a socio-interactionist approach constitutes a relevant strategy for teaching the sensory system in the school context.
Movimento social como resistência na universidade: processos de subjetivação em um coletivo de causas indígenas
(Universidade Federal de São Carlos, 2026-07-07)
Oliveira, Tyfany Maia de
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Martins, Mário Henrique da Mata
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http://lattes.cnpq.br/5503003894437331
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Yepá Mahsã
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http://lattes.cnpq.br/4618296954486958
Universidade Federal São Carlos pahka bu’eturiakari wi’ipᵾ, mari ukũ tuhtuase turi na ma’mapiha bu’e wahakũ tuhtuase kahãsere i’ña behsewe, bu’ese ukũri turi ni. A’te i’ña behesewe bu’ese nisa, mari ñehkusᵾmᵾa, ahkawererã na ukũ, a’te pahka bu’ese wi’seripᵾ mari po’rã ke’rã bu’eato ni na ukũ ahpokuke. Toho wego a’tere i’ña behsewe bu’egotigo a’rã pᵾarã pehkasã pahka bu’ekarã na ohakukepu mipoteõnoapᵾ Manuel Castells toho nika Michel Foucault. Te bu’esere ohakugotigo na ma’mapiha mera nerenuhueha ukũ a’mesᵾo weke ni. Toho werã ni’kamukᵾse pᵾapika pe’ri pehase bu’erã mera da’ranoke ni. Naa mera ukũ, seriti’ña weka be’rore, ahpokũ ohanoawᵾ. Toho wekare maha topo’peapᵾre pa’paritise turi bahuawᵾ, te ni; a) Mari nisetise, mahsise, ukũse misanᵾkaeha ohakũ bue’se; b) Bu’eturiakã, ukũtuhua bu’enemokãse a’ti Pahirituri bu’ese niri wipᵾ; c) Ti bu’eri kura po’peapᵾre a’meri ma’i ehõpeo, wehepeose; d) ti bue’rikura añuro wahkũ, ukũtuhtua miasekahãse. A’te bu’e, nerenuha ukũ a’mesᵾoke meramaha nisa na mamapihare wahkũ tuhutuakã wese nisa, a’to Pahka Bu’eturiakãse weri wi’i po’peapᵾre.
Estudos in vivo da atividade antitumoral de uma desintegrina inibidora da integrina αvβ3
(Universidade Federal de São Carlos, 2026-07-07)
Almeida Junior, Paulo Cesa
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Lino, Rafael Luis Bressani
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http://lattes.cnpq.br/9514190453774618
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Selistre-de-Araujo, Heloisa Sobreiro
;
http://lattes.cnpq.br/4065824911933203
Cancer represents a complex ecosystem composed of tumor cells and a diverse population of non-malignant cells embedded within an altered extracellular matrix. The tumor microenvironment (TME) comprises various immune cell types, cancer-associated fibroblasts, endothelial cells, pericytes, and several additional tissue-resident cell populations. These host cells were once regarded as mere bystanders in tumorigenesis but are now recognized as playing critical roles in cancer pathogenesis. During vascular remodeling and angiogenesis, for example, endothelial cells upregulate the expression of several cell-surface molecules that promote tumor cell invasion and proliferation, including integrin αvβ3. Integrin αvβ3 is a vitronectin receptor that recognizes the adhesive motif RGD and plays an essential role in directing cell migration. Our group has previously investigated this integrin using the recombinant disintegrin DisBa-01, derived from Bothrops alternatus venom and produced as a His-tag recombinant protein through heterologous expression and purification. The aim of the present study was to evaluate the potential effects of the pharmacological inhibition of integrin αvβ3 on angiogenesis and tumor progression in a syngeneic experimental model of triple-negative breast cancer. The effects of local and systemic inhibition of integrin αvβ3 on primary tumor development were evaluated in female BALB/c mice inoculated with 4T1Br4-mCherry cells. Following tumor establishment, the animals were allocated into two experimental models (Non-surgical Spontaneous Metastasis and Surgical Spontaneous Metastasis), each comprising three groups (Control Group 1, DisBa-01 Group, and Control Group 2), and were treated for a defined period. After euthanasia, tissue samples from multiple organs were collected for subsequent real-time quantitative PCR, histological, and immunofluorescence analyses. The study was approved by the Animal Ethics Committee of the Federal University of São Carlos under protocol number 9550180823. The results demonstrated that pharmacological inhibition of integrin αvβ3 by DisBa-01 modulated the tumor microenvironment, producing both pro-tumorigenic and antitumor effects in both experimental models. Increased collagen deposition was observed in tumors from Experiment 1, whereas a greater potential for tumor recurrence was detected in the DisBa-01-treated group in Experiment 2. In addition, reduced pulmonary metastasis was confirmed by qPCR in both experiments. Comparatively, animals that did not undergo surgery exhibited a better therapeutic response, whereas the surgical model showed greater metastatic dissemination and reduced survival. Collectively, these findings indicate that inhibition of integrin αvβ3 alone was insufficient to restrain tumor progression in vivo, highlighting the need for further studies to elucidate its relationship with the tumor microenvironment.
Simulação e reconstrução de hologramas de objetos 2D e 3D por camadas usando Python
(Universidade Federal de São Carlos, 2026-07-07)
Pereira, Pedro Miguel
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Gomes, Vinicius Tribuzi Rodrigues Pinheiro
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http://lattes.cnpq.br/5519527278619089
This work presents the development and evaluation of routines for generating and reading digital holograms using the Python programming language and the LightPipes library. The methodology involved simulating light propagation and diﬀraction—using the convolution method—for two-dimensional and layered three-dimensional objects, employing an in-line holography conﬁguration. Subsequently, the implemented routines were applied to process holograms sourced from papers on marine zooplankton. The results demonstrate that the holograms computationally generated by these routines adequately preserve information regarding the shape, transmittance, and depth of the simulated objects, allowing for high-ﬁdelity recovery. The routines’ ability to reconstruct images from holograms obtained in real experiments is also demonstrated, even when some experimental parameters are unavailable.
Otimização de portfólios no mercado brasileiro: uma análise da robustez do modelo de Markowitz frente à diversificação ingênua via simulações computacionais
(Universidade Federal de São Carlos, 2026-07-07)
Philippsen , Gabriel
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Lopes Rosa , Beatriz
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Rodrigues, Ariano De Giovanni
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http://lattes.cnpq.br/4881530489438346
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https://orcid.org/0000-0003-0294-6775
A otimização de carteiras segundo Markowitz (1952) enfrenta um obstáculo crítico na prática: a estimação dos parâmetros (retornos esperados μ e covariância Σ) a partir de amostras finitas introduz erros que degradam o desempenho fora da amostra. DeMiguel, Garlappi e Uppal (2009) demonstraram que a carteira 1/N (alocação igualitária) é competitiva em Índice de Sharpe frente a otimização formal. O presente trabalho amplia essa questão ao incorporar o Índice de Calmar, que enfatiza contenção de perdas de cauda, investigando em que dimensões de desempenho o Portfólio de Mínima Variância Global (PMVG) supera o 1/N no mercado brasileiro. A metodologia implementa backtest rolling mensal de ambas as estratégias no período janeiro/2015–dezembro/2025 utilizando 15 ações de alta liquidez da B3, com janelas de estimação variáveis (1, 3, 5 e 10 anos). O desempenho é avaliado por Índice de Sharpe, Calmar, CAGR, volatilidade e máximo drawdown. Resultados confirmam que 1/N domina em Sharpe em ambos os horizontes (2015–2019: 0,964 vs. 0,788; 2015–2025: 0,485 vs. 0,429), validando que erro de estimação em μ anula ganhos da otimização. A sensibilidade a janela de estimação revelou relação não-monotônica, com 3 anos produzindo desempenho ótimo. Contudo, em Índice de Calmar, a hierarquia se inverte: PMVG registra vantagem consistente (2015–2019: 1,313 vs. 1,162; 2015–2025: 0,598 vs. 0,544). Adicionalmente, PMVG apresenta volatilidade menor (16,11% vs. 20,75% em 2015–2025) e máximo drawdown menos severo (−29,5% vs. −38,2%). Conclui-se que a hierarquia entre estratégias é sensível ao critério: embora 1/N supere em retorno ajustado por volatilidade total, PMVG oferece proteção mensurável contra perdas de cauda, relevante para investidores conservadores. A escolha depende de qual critério alinha-se melhor com objetivos do investidor.Markowitz's portfolio optimization paradigm faces a critical practical obstacle: parameter estimation (expected returns μ and covariance Σ) in finite samples introduces estimation error that degrades out-of-sample performance. DeMiguel, Garlappi, and Uppal (2009) demonstrated that the equal-weight portfolio (1/N) without any estimated parameters is competitive in Sharpe Ratio against formal optimization strategies. This work extends that inquiry by incorporating the Calmar Ratio, which emphasizes tail loss containment, investigating in which performance dimensions the Global Minimum Variance Portfolio (GMVP) outperforms the 1/N allocation in the Brazilian stock market. The methodology implements monthly rolling backtests of both strategies over January 2015–December 2025 using 15 high-liquidity B3 stocks, with varying estimation windows (1, 3, 5, and 10 years). Performance is evaluated by Sharpe Ratio, Calmar Ratio, CAGR, annualized volatility, and maximum drawdown. Results confirm that the 1/N portfolio dominates the GMVP in Sharpe Ratio across both horizons (2015–2019: 0.964 vs. 0.788; 2015–2025: 0.485 vs. 0.429), validating that estimation error in μ annuls the theoretical gains of optimization. Sensitivity to the estimation window revealed a non-monotonic relationship, with a 3-year window producing optimal global performance. However, when the evaluative dimension is the Calmar Ratio, the hierarchy inverts: GMVP registers consistent advantage (2015–2019: 1.313 vs. 1.162; 2015–2025: 0.598 vs. 0.544). Additionally, GMVP exhibits lower volatility (16.11% vs. 20.75% over 2015–2025) and less severe maximum drawdown (−29.5% vs. −38.2%). We conclude that the hierarchy between strategies is sensitive to the evaluative criterion: while 1/N outperforms in total return-adjusted risk (Sharpe), GMVP provides measurable protection against tail losses, relevant for conservative investors. The choice depends on which criterion best aligns with the investor's specific objectives.
Queerbaiting em "Sobrenatural": a exploração da comunidade LGBTQIA+ como audiência
(Universidade Federal de São Carlos, 2026-07-07)
Lara, Sara Nery de
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Carvalho , Pedro Henrique Varoni de
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http://lattes.cnpq.br/0019513394358070
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https://orcid.org/0000-0002-1492-4891
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http://lattes.cnpq.br/3127992877588057
This study analyzes the phenomenon known as queerbaiting in the television series Supernatural (2005), focusing on the construction of the character Dean Winchester with the goal of investigating how narrative, audiovisual, and extratextual elements suggest the possible bisexuality of the character without effectively confirming such representation. Through a qualitative, bibliographic, and interpretative approach, based on the analysis of episodes and statements made by actors, writers and producers, the findings indicate that Supernatural employs elements that allow ambiguous interpretation of Dean’s sexuality, while avoiding its confirmation and delegitimizing this reading, despite the constant demand by the fanbase for more openly queer characters,. We conclude that this practice contributes to the maintenance of heteronormativity and the limitation of LGBTQIA+ portrayals in the media. This research aims to amplify the discussion of representation in audiovisual narratives as well as the importance of more authentic and inclusive content in television fiction.
Análise comparativa de modelos de fechamento na simulação fluidodinâmica de uma coluna de bolhas
(Universidade Federal de São Carlos, 2026-07-07)
Souza, Lucas Santos
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Laizo, Welberth Santos
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http://lattes.cnpq.br/4647926156980030
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Lopes, Gabriela Cantarelli
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http://lattes.cnpq.br/5680967191791061
Bubble columns are widely used in chemical, petrochemical, biochemical, and environmental processes due to their high mass and heat transfer efficiency. In this context, gas holdup is one of the main hydrodynamic parameters, directly influencing reactor performance. This work evaluated the influence of different closure models on the prediction of gas holdup in a bubble column using Computational Fluid Dynamics (CFD) simulations performed in the STARCCM+ software. Initially, a mesh independence study was conducted using the Grid Convergence Index (GCI) to ensure the numerical reliability of the simulations. Subsequently, different turbulence models, bubble diameter models, interfacial force models, and the inclusion of bubble breakup and coalescence mechanisms were investigated. The simulation results were mainly assessed by comparison with gas holdup correlations available in the literature and were additionally confronted with experimental data. The mesh independence study confirmed numerical convergence and the reliability of the adopted discretization. Among the evaluated models, the k-ω turbulence model showed the best performance in predicting gas holdup, presenting the lowest residuals throughout the simulations. Bubble diameter correlations and drag models were found to be the most influential factors in gas holdup prediction, leading to the largest variations in the simulated results, whereas lift and bubble breakup and coalescence models had a smaller impact on this variable. The inclusion of breakup and coalescence models did not lead to consistent improvements in gas holdup prediction, despite the associated increase in computational cost. Furthermore, empirical correlations showed accuracy dependence on the operating range when compared with experimental data, failing to adequately represent all studied conditions. Overall, the results demonstrate that the appropriate selection of closure models is essential for reliable predictions of gas holdup and system hydrodynamics, confirming the potential of CFD as a tool for analysis and support in the development and optimization of bubble columns.